1c4p

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (23:23, 27 December 2023) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:1c4p.gif|left|200px]]
 
-
<!--
+
==BETA DOMAIN OF STREPTOKINASE==
-
The line below this paragraph, containing "STRUCTURE_1c4p", creates the "Structure Box" on the page.
+
<StructureSection load='1c4p' size='340' side='right'caption='[[1c4p]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[1c4p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1C4P FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1c4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4p OCA], [https://pdbe.org/1c4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1c4p RCSB], [https://www.ebi.ac.uk/pdbsum/1c4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1c4p ProSAT]</span></td></tr>
-
{{STRUCTURE_1c4p| PDB=1c4p | SCENE= }}
+
</table>
-
 
+
== Function ==
-
'''BETA DOMAIN OF STREPTOKINASE'''
+
[https://www.uniprot.org/uniprot/Q53284_STREQ Q53284_STREQ]
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
==Overview==
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/c4/1c4p_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1c4p ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.
Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.
-
==About this Structure==
+
Crystal structure of streptokinase beta-domain.,Wang X, Tang J, Hunter B, Zhang XC FEBS Lett. 1999 Oct 1;459(1):85-9. PMID:10508922<ref>PMID:10508922</ref>
-
1C4P is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_dysgalactiae_subsp._equisimilis Streptococcus dysgalactiae subsp. equisimilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C4P OCA].
+
-
==Reference==
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
Crystal structure of streptokinase beta-domain., Wang X, Tang J, Hunter B, Zhang XC, FEBS Lett. 1999 Oct 1;459(1):85-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10508922 10508922]
+
</div>
-
[[Category: Single protein]]
+
<div class="pdbe-citations 1c4p" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Streptococcus dysgalactiae subsp. equisimilis]]
[[Category: Streptococcus dysgalactiae subsp. equisimilis]]
-
[[Category: Wang, X.]]
+
[[Category: Wang X]]
-
[[Category: Zhang, X C.]]
+
[[Category: Zhang XC]]
-
[[Category: Plasminogen activator]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:19:23 2008''
+

Current revision

BETA DOMAIN OF STREPTOKINASE

PDB ID 1c4p

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1c4p"
Personal tools