This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


DNA damage-binding protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:49, 30 January 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 26: Line 26:
**[[6dsz]] – hDDB + DET1 peptide<br />
**[[6dsz]] – hDDB + DET1 peptide<br />
**[[4a11]], [[6fcv]] – hDDB + DNA excision repair protein ERCC-8<br />
**[[4a11]], [[6fcv]] – hDDB + DNA excision repair protein ERCC-8<br />
 +
**[[8d7x]], [[8d7y]] – hDDB + cereblon <br />
 +
**[[8cvp]] – hDDB + cereblon – Cryo EM<br />
 +
**[[6zue]] – hDDB + DCAF1<br />
 +
**[[8ajn]] – hDDB + DCAF1 – Cryo EM<br />
 +
**[[7ukn]] – hDDB + herpes virus protein br />
 +
**[[7p7b]] – hDDB + VPRBP – Cryo EM<br />
*DDB1 ternary complex
*DDB1 ternary complex
-
**[[4ci1]], [[4ci2]], [[4ci3]], [[4tz4]] – hDDB + cereblon + thalidomide derivative<br />
+
**[[4ci1]], [[4ci2]], [[4ci3]], [[4tz4]], [[8d81]] – hDDB + cereblon + thalidomide derivative<br />
**[[5v3o]] – hDDB + cereblon + piperidine derivative<br />
**[[5v3o]] – hDDB + cereblon + piperidine derivative<br />
**[[5fqd]] – hDDB + cereblon + casein kinase 1<br />
**[[5fqd]] – hDDB + cereblon + casein kinase 1<br />
-
**[[5hxb]] – hDDB + cereblon + ERF3A<br />
+
**[[5hxb]], [[6xk9]] – hDDB + cereblon + ERF3A<br />
**[[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hDDB + cereblon + BRD4<br />
**[[6bn8]], [[6bn9]], [[6bnb]], [[6boy]] – hDDB + cereblon + BRD4<br />
 +
**[[7lps]] – hDDB + cereblon + IKAROS<br />
 +
**[[8d7u]], [[8d7v]], [[8d7w]] – hDDB + cereblon + mezigdomide<br />
**[[6h0f]] – hDDB (mutant) + cereblon + IKAROS<br />
**[[6h0f]] – hDDB (mutant) + cereblon + IKAROS<br />
**[[6h0g]] – hDDB (mutant) + cereblon + ZNF692<br />
**[[6h0g]] – hDDB (mutant) + cereblon + ZNF692<br />
**[[6td3]] – hDDB + cyclin-dependent kinase 12 + cyclin-K<br />
**[[6td3]] – hDDB + cyclin-dependent kinase 12 + cyclin-K<br />
 +
**[[7zn7]], [[7znn]] – hDDB (mutant) + herpes virus protein + STAT2 – Cryo EM<br />
 +
**[[6zx9]] – hDDB + SIV protein + VPRBP <br />
 +
**[[8ajm]], [[8ajo]] – hDDB + DCAF1 + CCT5 – Cryo EM<br />
*DDB1 quaternary complex
*DDB1 quaternary complex
**[[6uml]] – hDDB + cereblon + ZNF797 + thalidomide derivative <br />
**[[6uml]] – hDDB + cereblon + ZNF797 + thalidomide derivative <br />
 +
**[[6bn7]] – hDDB + cereblon + BRD4 + piperidine derivative<br />
 +
**[[8d7z]], [[8d80]] – hDDB + cereblon + IKAROS + drug<br />
**[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br />
**[[2hye]] – hDDB + simian virus 5 protein + cullin-4A + ring-box protein 1<br />
 +
**[[5jk7]] – hDDB + HIV protein + uracil-DNA glycosylase + VPRBP <br />
 +
**[[7v7c]] – hDDB + HIV protein + uracil-DNA glycosylase + VPRBP – Cryo EM<br />
 +
**[[7okq]] – hDDB + DCAF1 + cullin-4A + RBX1 – Cryo EM<br />
**[[6pai]], [[6q0r]], [[6ue5]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + sulfonamide derivative<br />
**[[6pai]], [[6q0r]], [[6ue5]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + sulfonamide derivative<br />
**[[6q0v]], [[6q0w]], [[6ud7]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug<br />
**[[6q0v]], [[6q0w]], [[6ud7]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug<br />
**[[6sj7]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug – Cryo EM<br />
**[[6sj7]] – hDDB + DDA1 + RNA-binding protein 39 + DET1 + anti-cancer drug – Cryo EM<br />
-
**[[5jk7]] – hDDB + VPRBP + uracil-DNA glycosylase + VPR<br />
+
**[[7oo3]], [[7oob]], [[7oop]], [[7opc]], [[7opd]] – hDDB in transcription-DNA repair coupling – Cryo EM<br />
 +
 
*DDB1+DDB2
*DDB1+DDB2

Current revision

Human DDB1 (cyan) and DDB2 (green) complex with DNA, and tetraethylene glycol (PDB code 3ei1).

Drag the structure with the mouse to rotate

3D Structures of DNA damage-binding protein

Updated on 30-January-2023


References

  1. ↑ Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapic-Otrin V. The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A. Cancer Res. 2008 Jul 1;68(13):5014-22. PMID:18593899 doi:68/13/5014

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/DNA_damage-binding_protein"
Personal tools