DXP reductoisomerase

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DXR <scene name='70/708083/Cv/8'>active site</scene> contains Mn<sup>+2</sup> cation and the product analog fosmidomycin. <scene name='70/708083/Cv/9'>Click here to see NADPH binding site</scene> (water molecules shown as red spheres).<ref>PMID:23819803</ref>
DXR <scene name='70/708083/Cv/8'>active site</scene> contains Mn<sup>+2</sup> cation and the product analog fosmidomycin. <scene name='70/708083/Cv/9'>Click here to see NADPH binding site</scene> (water molecules shown as red spheres).<ref>PMID:23819803</ref>
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</StructureSection>
 
== 3D Structures of DXP reductoisomerase==
== 3D Structures of DXP reductoisomerase==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[DXP reductoisomerase 3D Structures]]
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{{#tree:id=OrganizedByTopic|openlevels=0|
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*DXP reductoisomerase
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</StructureSection>
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**[[1k5h]], [[1onn]] – EcDXR – ''Escherichia coli''<br />
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**[[1r0k]] – ZmDXR – ''Zymomonas mobilis''<br />
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**[[2c82]] – MtDXR – ''Mycobacterium tuberculosis''<br />
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**[[2jcy]] – MtDXR (mutant) <br />
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**[[4zn6]] – DXR – ''Acinetobacter baumannii'' <br />
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**[[4zqe]] – McDXR – ''Moraxella catarrhalis''<br />
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**[[5kqo]], [[5kry]], [[5ks1]] – VvDXR – ''Vibrio vulnificus''<br />
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**[[6mh4]] – SsDXR – ''Staphylococcus schleiferi''<br />
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*DXP reductoisomerase binary complex
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**[[1t1r]], [[1t1s]] – EcDXR + bisphosphonate<br />
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**[[1jvs]] – EcDXR + NADPH<br />
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**[[1r0l]] – ZmDXR + NADPH<br />
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**[[2jd1]] – MtDXR + NADPH<br />
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**[[2jd0]] – MtDXR (mutant) + NADPH<br />
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**[[2jd2]], [[2y1c]], [[2y1e]] – MtDXR + Mn<br />
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**[[3zhz]] – MtDXR + anti-malaria drug<br />
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**[[1ono]] – EcDXR + Mn<br />
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**[[3iie]] – YpDXR + Mg – ''Yersinia pestis''<br />
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**[[5dul]] – YpDXR + NADPH<br />
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**[[5krr]] – VvDXR + Mn<br />
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**[[5krv]] – VvDXR + Arg<br />
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**[[6mh5]] – SsDXR + antibiotic<br />
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*DXP reductoisomerase ternary complex
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**[[2jcv]] – MtDXR + NADPH + anti-malaria drug<br />
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**[[2y1d]], [[2y1g]], [[3zhx]], [[3zi0]] – MtDXR + Mn + anti-malaria drug<br />
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**[[2jcx]] – MtDXR (mutant) + NADPH + anti-malaria drug<br />
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**[[1onp]], [[3r0i]] – EcDXR + Mn + anti-malaria drug<br />
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**[[1q0h]], [[1q0l]] – EcDXR + NADPH + anti-malaria drug<br />
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**[[1q0q]] – EcDXR + NADPH + DXP<br />
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**[[3anl]], [[3anm]], [[3ann]] – EcDXR + NADPH + lipophilic phosphonate<br />
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**[[3a14]] – TmDXR + NADPH + Mg – ''Thermotoga maritima''<br />
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**[[3au8]] – PfDXR + NADPH + Mn – ''Plasmodium falciparum''<br />
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**[[4y67]], [[4y6p]], [[4y6r]], [[4y6s]], [[5jaz]], [[5jbi]], [[5jc1]], [[5jmp]], [[5jmw]], [[5jnl]], [[5jo0]] – PfDXR + Mn + anti-malaria drug<br />
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**[[4zqf]] – McDXR + Mg + anti-malaria drug<br />
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*DXP reductoisomerase quaternary complex
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**[[2egh]] – EcDXR + NADPH + Mg + anti-malaria drug<br />
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**[[3a06]] – TmDXR + NADPH + Mg + anti-malaria drug <br />
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**[[3au9]], [[3aua]] – PfDXR + NADPH + Mg + anti-malaria drug <br />
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**[[4kp7]] – PfDXR + NADPH + Mn + anti-malaria drug <br />
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**[[2y1f]], [[4a03]], [[4aic]], [[3zhy]] – MtDXR + NADPH + Mn + anti-malaria drug <br />
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**[[4ooe]], [[4oof]] – MtDXR (mutant) + NADPH + Mn + anti-malaria drug <br />
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**[[3ras]] – MtDXR + NADPH + Mn + lipophilic phosphonate<br />
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**[[4rcv]] – MtDXR + NADPH + Mn + 1-deoxy-L-erythrulose<br />
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**[[4gae]] – PfDXR (mutant) + NADPH + Mn + pyridine inhibitor <br />
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**[[3wqq]], [[3wqr]], [[3wqs]] – PfDXR + NADPH + Mg + inhibitor <br />
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**[[4zqg]] – McDXR + NAD + Mg + anti-malaria drug<br />
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**[[4zqh]] – McDXR + NADPH + Mg + anti-malaria drug<br />
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}}
 
== References ==
== References ==
<references/>
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

DXP reductoisomerase complex with NADPH, Mn+2 ion (green) and anti-malaria drug fosmidomycin (PDB code 3zhy)

Drag the structure with the mouse to rotate

References

  1. ↑ Takahashi S, Kuzuyama T, Watanabe H, Seto H. A 1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzing the formation of 2-C-methyl-D-erythritol 4-phosphate in an alternative nonmevalonate pathway for terpenoid biosynthesis. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9879-84. PMID:9707569
  2. ↑ Jansson AM, Wieckowska A, Bjorkelid C, Yahiaoui S, Sooriyaarachchi S, Lindh M, Bergfors T, Dharavath S, Desroses M, Suresh S, Andaloussi M, Nikhil R, Sreevalli S, Srinivasa BR, Larhed M, Jones TA, Karlen A, Mowbray SL. DXR inhibition by potent mono- and disubstituted fosmidomycin analogues. J Med Chem. 2013 Aug 8;56(15):6190-9. doi: 10.1021/jm4006498. Epub 2013 Jul 17. PMID:23819803 doi:http://dx.doi.org/10.1021/jm4006498

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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