Elongation factor 3D structures

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Line 13: Line 13:
**[[1mj1]] – EcEF + Phe-tRNA + S12 + S13 + L11 – Cryo EM<BR />
**[[1mj1]] – EcEF + Phe-tRNA + S12 + S13 + L11 – Cryo EM<BR />
**[[3ep2]] - EcEF + tRNA + S12 + L11 + 16SRRNA + 23SRRNA – Cryo EM<BR />
**[[3ep2]] - EcEF + tRNA + S12 + L11 + 16SRRNA + 23SRRNA – Cryo EM<BR />
 +
**[[8qhc]] - EcEF + tRNA + SidH + E3 ubiquitin protein ligase – Cryo EM<BR />
**[[1ttt]], [[1ob5]] – TaEF + Phe-tRNA + GDPNP - ''Thermus aquaticus''<BR />
**[[1ttt]], [[1ob5]] – TaEF + Phe-tRNA + GDPNP - ''Thermus aquaticus''<BR />
**[[1b23]] - TaEF + Cys-tRNA<BR />
**[[1b23]] - TaEF + Cys-tRNA<BR />
Line 20: Line 21:
**[[4j0q]] – PpEF – ''Pseudomonas putida''<br />
**[[4j0q]] – PpEF – ''Pseudomonas putida''<br />
**[[5w75]] – EF – ''Thermotoga neapolitana''<br />
**[[5w75]] – EF – ''Thermotoga neapolitana''<br />
-
**[[5tbf]] – EF domain 2-3– ''Vibrio cholerae''<br />
+
**[[8yly]], [[8ym3]] – EF – ''Synechococcus elongatus''<br />
-
**[[6htw]], [[6i8r]] – EF – synthetic<br />
+
**[[5tbf]] – EF domain 2-3– ''Vibrio cholerae"
 +
**[[5w76]], [[6htw]], [[6i8r]], [[7bbn]] – EF – synthetic<br />
*''EF-Tu complex with antibiotics''
*''EF-Tu complex with antibiotics''
Line 31: Line 33:
**[[4v68]] – TtEF + antibiotic in 70S ribosome – Cryo EM<BR />
**[[4v68]] – TtEF + antibiotic in 70S ribosome – Cryo EM<BR />
**[[2bvn]] - EcEF + GDP<BR />NP + antibiotic<BR />
**[[2bvn]] - EcEF + GDP<BR />NP + antibiotic<BR />
-
**[[1d8t]], [[2hcj]], [[2hdn]], [[3u6b]], [[3u6k]], [[4g5g]], [[5jbq]] – EcEF + antibiotic
+
**[[1d8t]], [[2hcj]], [[2hdn]], [[3u6b]], [[3u6k]], [[4g5g]], [[5jbq]], [[8fr3]] – EcEF + antibiotic<br />
 +
**[[7st7]] – EcEF + antibiotic in 70S ribosome – Cryo EM<BR />
*''EF-Tu complex with nucleotide''
*''EF-Tu complex with nucleotide''
Line 45: Line 48:
**[[6mij]] – AbEF + GDP – ''Acinetobacter baumannii''<br />
**[[6mij]] – AbEF + GDP – ''Acinetobacter baumannii''<br />
**[[6gfu]] – EF + GDP – synthetic<br />
**[[6gfu]] – EF + GDP – synthetic<br />
 +
**[[7vok]] – MtEF + GDP – ''Mycobacterium tuberculosis''<br />
*''EF-Tu complex with protein''
*''EF-Tu complex with protein''
Line 51: Line 55:
**[[3wy9]] – PhEF + L12 <br />
**[[3wy9]] – PhEF + L12 <br />
**[[4p3y]] – EcEF + thiol:disulfide interchange protein <br />
**[[4p3y]] – EcEF + thiol:disulfide interchange protein <br />
-
**[[5i4r]], [[5i4q]] – EcEF + CDIA + CDII <br />
+
**[[8qfs]] – EcEF + SidH + tRNA <br />
 +
**[[5i4r]], [[5i4q]], [[7vmc]] – EcEF + CDIA + CDII <br />
**[[4zv4]] – PaEF + TSE6 - ''Pseudomonas aeruginosa''<br />
**[[4zv4]] – PaEF + TSE6 - ''Pseudomonas aeruginosa''<br />
 +
**[[4iw3]] – PpEF + prolyl hydroxylase <br />
 +
**[[5v7y]] – EF + prolyl hydroxylase – ''Bacillus anthracis''<br />
 +
**[[8xi2]] – EF in C* complex – ''Chlamydomonas reinhardtii'' – Cryo EM <br />
*''EF-Tu with EF-Ts''
*''EF-Tu with EF-Ts''
Line 70: Line 78:
**[[4pc2]], [[4pc3]], [[4pc6]] – EcEF + EcEF-Ts + GDP derivative<br />
**[[4pc2]], [[4pc3]], [[4pc6]] – EcEF + EcEF-Ts + GDP derivative<br />
**[[1aip]] - TtEF + TtEF-Ts - ''Thermus thermophilus''<BR />
**[[1aip]] - TtEF + TtEF-Ts - ''Thermus thermophilus''<BR />
 +
**[[7vmx]] – MtEF + MtEF-Ts <br />
*''EF-Tu in the ribosome''
*''EF-Tu in the ribosome''
-
**[[3eq3]], [[3eq4]] – EcEF in 80S ribosome – Cryo EM<BR />
+
**[[7a5g]], [[7o9k]] – hEF in 80S mitoribosome + GMPPCP – Cryo EM<BR />
 +
**[[3eq3]], [[3eq4]], [[5afi]] – EcEF in 80S ribosome – Cryo EM<BR />
 +
**[[6wd2]], [[6wd3]], [[6wd4]], [[6wd5]], [[6wd6]], [[6wd7]], [[6wd8]], [[6wd9]], [[6wda]] – EcEF in 80S ribosome + GDP – Cryo EM<BR />
**[[4v6l]], [[4v6k]], [[4v69]] - EcEF in 30S ribosome – Cryo EM<BR />
**[[4v6l]], [[4v6k]], [[4v69]] - EcEF in 30S ribosome – Cryo EM<BR />
 +
**[[5lzc]], [[5uyk]], [[5uyl]], [[5uym]], [[5uyn]], [[5uyp]], [[5uyq]], [[5wdt]], [[5we4]], [[5we6]], [[5wf0]], [[5wfk]], [[5wfs]] -  EcEF in 70S ribosome – Cryo EM<BR />
 +
**[[5imq]], [[5imr]], [[6zmo]] -  EcEF in 70S ribosome + Nsp1– Cryo EM<BR />
 +
**[[8g7p]], [[8g7q]] - EcEF in 70S ribosome + tRNA – Cryo EM<BR />
**[[1zc8]], [[3dwu]] – TtEF in 70S ribosome – Cryo EM<BR />
**[[1zc8]], [[3dwu]] – TtEF in 70S ribosome – Cryo EM<BR />
 +
**[[7paj]], [[7pak]], [[7pao]], [[7paq]], [[7par]], [[7pha]], [[7pi4]], [[7pi9]], [[7pib]], [[7pip]], [[7pis]], [[7pit]] – MpEF in 70S ribosome – ''Mycoplasma pneumoniae'' - Cryo EM<BR />
**[[4v5g]], [[4v5l]], [[4v5p]], [[4v5q]], [[4v5r]], [[4v5s]] - TtEF in 70S ribosome
**[[4v5g]], [[4v5l]], [[4v5p]], [[4v5q]], [[4v5r]], [[4v5s]] - TtEF in 70S ribosome
 +
**[[8v9l]] – EF in 70S ribosome – ''Mycobacterium smegmatis'' - Cryo EM<BR />
*EF-SII
*EF-SII
Line 82: Line 98:
**[[1tfi]] – hEF – human – NMR<BR />
**[[1tfi]] – hEF – human – NMR<BR />
**[[3ndq]] - hEF domain II<BR />
**[[3ndq]] - hEF domain II<BR />
 +
**[[8a40]] – hEF in RNA Pol II complex – Cryo EM <br />
**[[1wjt]] – mEF N terminal – mouse – NMR<BR />
**[[1wjt]] – mEF N terminal – mouse – NMR<BR />
 +
**[[8h6r]] – EF LW domain – ''Arabidopsis thaliana''<br />
**[[1enw]] – yEF domain II – NMR<BR />
**[[1enw]] – yEF domain II – NMR<BR />
**[[1eo0]] - yEF domain I – NMR<BR />
**[[1eo0]] - yEF domain I – NMR<BR />
**[[1pqv]], [[1y1v]] – yEF + RNA polymerase II<BR />
**[[1pqv]], [[1y1v]] – yEF + RNA polymerase II<BR />
**[[1y1y]], [[3gtm]] – yEF + RNA polymerase II + RNA<BR />
**[[1y1y]], [[3gtm]] – yEF + RNA polymerase II + RNA<BR />
 +
**[[8uoq]], [[8uot]] – yEF + RNA polymerase II + RNA – Cryo EM
**[[2xex]] – SaEF – ''Staphylococcus aureus''<BR />
**[[2xex]] – SaEF – ''Staphylococcus aureus''<BR />
-
**[[2m1h]] – EF PWWP domain – ''Trypanosoma brucei'' – NMR<br />
+
**[[2m1h]] – TbEF PWWP domain – ''Trypanosoma brucei'' – NMR<br />
 +
**[[7xgw]] – TbEF LN domain <br />
*EF-ELL2
*EF-ELL2
Line 99: Line 119:
**[[1efg]], [[1elo]], [[1ktv]], [[1wdt]], [[2dy1]] – TtEF<BR />
**[[1efg]], [[1elo]], [[1ktv]], [[1wdt]], [[2dy1]] – TtEF<BR />
**[[4m1k]], [[4myt]], [[4myu]] – TtEF (mutant)<br />
**[[4m1k]], [[4myt]], [[4myu]] – TtEF (mutant)<br />
-
**[[1pn6]], [[3izp]] – TtEF – Cryo EM<BR />
+
**[[1pn6]], [[3izp]], [[5ot7]] – TtEF – Cryo EM<BR />
**[[1fnm]], [[2bm0]], [[2bm1]] – TtEF (mutant) <BR />
**[[1fnm]], [[2bm0]], [[2bm1]] – TtEF (mutant) <BR />
**[[2bcw]] – TtEF + L11 + L7/L12 <br />
**[[2bcw]] – TtEF + L11 + L7/L12 <br />
Line 114: Line 134:
**[[6bk7]] – EF N terminal – ''Enterococcus faecalis''<br />
**[[6bk7]] – EF N terminal – ''Enterococcus faecalis''<br />
**[[6n0i]] – PpEF 2<br />
**[[6n0i]] – PpEF 2<br />
 +
**[[7cdw]] – MtEF <br />
**[[2xex]] – SaEF<BR />
**[[2xex]] – SaEF<BR />
**[[3zz0]], [[3zzt]], [[3zzu]] – SaEF (mutant) <BR />
**[[3zz0]], [[3zzt]], [[3zzu]] – SaEF (mutant) <BR />
 +
**[[2mzw]] – SaEF domains III-V + FAR1<BR />
*''EF-G in the ribosome''
*''EF-G in the ribosome''
-
**[[4v8u]], [[4v5m]], [[4v5n]] – TtEF in 70S ribosome <BR />
+
**[[4v6x]], [[6vlz]], [[6z6m]], [[6z6n]], [[7a5k]], [[7w59]], [[7w5a]] – hEF in 80S ribosome – Cryo EM<BR />
-
**[[2om7]], [[4v5f]] – TtEF in 70S ribosome – Cryo EM<BR />
+
**[[6vmi]] – hEF in 80S mitoribosome – Cryo EM<BR />
 +
**[[7l20]] – hEF in 39S mitoribosome – Cryo EM<BR />
 +
**[[7nsh]] – pEF in 39S ribosome – pig - Cryo EM<BR />
 +
**[[6ydp]], [[6ydw]] – pEF in 55S ribosome – Cryo EM<BR />
 +
**[[7oyd]] – rEF in 80S ribosome – Cryo EM<BR />
 +
**[[4v6w]] – DmEF in 80S ribosome – Cryo EM<BR />
 +
**[[4v8u]], [[4v5m]], [[4v5n]], [[4w29]], [[4wpo]], [[4wqf]], [[4wqu]], [[4wqy]] – TtEF in 70S ribosome <BR />
 +
**[[2om7]], [[4v5f]], [[4v7c]] – TtEF in 70S ribosome – Cryo EM<BR />
**[[4v9h]], [[4v9j]], [[4v9k]], [[4v9l]], [[4v9m]], [[4v90]] – TtEF in 30S ribosome <BR />
**[[4v9h]], [[4v9j]], [[4v9k]], [[4v9l]], [[4v9m]], [[4v90]] – TtEF in 30S ribosome <BR />
**[[4v9o]], [[4v9p]] – EcEF in 30S ribosome <BR />
**[[4v9o]], [[4v9p]] – EcEF in 30S ribosome <BR />
**[[4v9d]] – EcEF in 30S ribosome + antibiotics – Cryo-EM<BR />
**[[4v9d]] – EcEF in 30S ribosome + antibiotics – Cryo-EM<BR />
-
**[[1zn0]], [[2rdo]], [[3j0e]], [[4v6t]], [[4v9b]] – EcEF in 30S ribosome – Cryo-EM<BR />
+
**[[1zn0]], [[2rdo]], [[3j0e]], [[3ja1]], [[4v6t]], [[4v9b]], [[7k51]], [[7k52]], [[7k54]] – EcEF in 30S ribosome – Cryo-EM<BR />
 +
**[[3j9z]], [[4v7b]], [[4v7d]], [[7k55]], [[7n2c]], [[7n2v]], [[7pjv]], [[7pjw]], [[7pjx]], [[7pjy]], [[7pjz]], [[7ssd]], [[7ssl]], [[7ssp]], [[7ug7]], [[9gha]], [[9ghc]], [[9ghd]] – EcEF in 70S ribosome – Cryo-EM<BR />
 +
**[[7otc]] – EcEF in 70S ribosome + antibiotics – Cryo-EM<BR />
 +
**[[8p2f]], [[8p2g]], [[8p2h]] – SaEF in 70S ribosome – Cryo-EM<BR />
*EF-GreA/GreB
*EF-GreA/GreB
Line 131: Line 163:
**[[2p4v]] – EcEF-GreB<br />
**[[2p4v]] – EcEF-GreB<br />
**[[1grj]] – EcEF-GreA<br />
**[[1grj]] – EcEF-GreA<br />
 +
**[[6ri7]], [[6rin]] – EcEF-GreB + transcriptase + DNA + RNA – Cryo EM<br />
*EF-NusA
*EF-NusA
Line 137: Line 170:
**[[2kwp]] - EcEF N terminal – NMR<BR />
**[[2kwp]] - EcEF N terminal – NMR<BR />
**[[2jzb]] – EcEF + RNA polymerase subunit α - NMR<BR />
**[[2jzb]] – EcEF + RNA polymerase subunit α - NMR<BR />
 +
**[[9f9u]] - EF – ''Saccharolobus solfataricus''<BR />
 +
**[[9fjl]] – NusA2 – ''Sulfolobus acidocaldarius''<BR />
*EF-P
*EF-P
Line 146: Line 181:
**[[3tre]] – EF – ''Coxiella burnetii''<br />
**[[3tre]] – EF – ''Coxiella burnetii''<br />
**[[3a5z]] – EcEF + lysyl-tRNA synthetase<br />
**[[3a5z]] – EcEF + lysyl-tRNA synthetase<br />
 +
**[[6enj]], [[6enu]] – EcEF – Cryo EM<br />
**[[1yby]] – EF – ''Clostridium thermocellum''<br />
**[[1yby]] – EF – ''Clostridium thermocellum''<br />
**[[5j3b]] – AbEF <br />
**[[5j3b]] – AbEF <br />
Line 153: Line 189:
**[[5wxk]] – EF + EARP – ''Neisseria meningitidis''<br />
**[[5wxk]] – EF + EARP – ''Neisseria meningitidis''<br />
 +
*EF-P-like
 +
**[[8s8u]] – EcEFL
*EF-Ts
*EF-Ts
Line 165: Line 203:
*EF-1
*EF-1
 +
**[[8b6z]], [[9azs]] – hEF alpha in 80S ribosome – Cryo EM <br />
**[[5dqs]] – hEF β+γ <br />
**[[5dqs]] – hEF β+γ <br />
**[[5jpo]] – hEF γ+δ <br />
**[[5jpo]] – hEF γ+δ <br />
**[[1pbu]] – hEF γ C terminal (mutant) - NMR<BR />
**[[1pbu]] – hEF γ C terminal (mutant) - NMR<BR />
**[[2mvm]], [[2mvn]] – hEF δ-1 CAR domain – NMR<br />
**[[2mvm]], [[2mvn]] – hEF δ-1 CAR domain – NMR<br />
 +
**[[2n51]] – hEF δ-1 C terminal – NMR<br />
**[[5bmu]] – hEF ε-1 + Glu tRNA ligase <br />
**[[5bmu]] – hEF ε-1 + Glu tRNA ligase <br />
**[[5y6l]] – hEF ε-1 (mutant) + MetRS + AspRS + Glu/Pro tRNA ligase + P38<br />
**[[5y6l]] – hEF ε-1 (mutant) + MetRS + AspRS + Glu/Pro tRNA ligase + P38<br />
-
**[[4c0s]], [[6ra9]] – rEF α-2 – rabbit<br />
+
**[[5lzs]] – rEF α-1 in 80S ribosome+ drug – rabbit<br />
 +
**[[4c0s]], [[6ra9]] – rEF α-2 <br />
**[[5o8w]] – yEF α+β <br />
**[[5o8w]] – yEF α+β <br />
**[[1nhy]] – yEF γ N terminal<br />
**[[1nhy]] – yEF γ N terminal<br />
 +
**[[7csl]] – PhEF α+β <br />
 +
 +
*EF-1 homolog
 +
 +
**[[8b3d]], [[8b3f]], [[9bz0]], [[9er2]], [[9fd2]] - hEFH in RNA pol II + TCR + RNA + DNA – Cryo EM<BR />
 +
**[[8tvy]] - yEFH in RNA pol II + TCR + RNA + DNA – Cryo EM<BR />
 +
**[[5xog]] - EFH in RNA pol II + Spt4/5 + RNA + DNA – ''Komagataella pastoris'' – Cryo EM<BR />
*EF-2
*EF-2
**[[4v4b]] - hEF in 40S ribosome – Cryo EM<BR />
**[[4v4b]] - hEF in 40S ribosome – Cryo EM<BR />
 +
**[[8xsx]] - hEF in 80S ribosome + tRNA + SERBP1 + drug – Cryo EM<BR />
 +
**[[3j7p]] - pEF in 80S ribosome – Cryo EM<BR />
**[[4cxg]], [[4cxh]] - rEF in 40S ribosome – Cryo EM<BR />
**[[4cxg]], [[4cxh]] - rEF in 40S ribosome – Cryo EM<BR />
 +
**[[7ls1]], [[7ls2]] - mEF in 80S ribosome – Cryo EM<BR />
 +
**[[8q87]] - EF in 80S ribosome + SERBP1 – chicken – Cryo EM<BR />
 +
**[[4v6w]] - DmEF in 40S ribosome – Cryo EM<BR />
 +
**[[7osm]] - yEF in 80S ribosome<BR />
 +
**[[5jup]], [[5jus]], [[5jut]], [[5juu]], [[6gq1]], [[7osa]], [[8cku]], [[8cmj]], [[8t3e]], [[8t3f]], [[8xu8]] - yEF in 80S ribosome – Cryo EM<BR />
 +
**[[8yld]], [[8ylr]] – yEF-2 + EF-3 in 80S ribosome – Cryo EM<BR />
 +
**[[8cdr]], [[8ceh]], [[8civ]] - yEF in 80S ribosome + antibiotic – Cryo EM<BR />
 +
**[[8eub]], [[8evs]], [[8ewb]] - yEF in 80S ribosome + IRES – Cryo EM<BR />
 +
**[[8evq]], [[8evr]], [[8t3a]], [[8t3b]], [[8t3c]], [[8t3d]] - yEF in 80S ribosome + IRES + antibiotic – Cryo EM<BR />
 +
**[[8umh]] - yEF in pol II complex – Cryo EM<BR />
**[[1n0v]] – yEF<BR />
**[[1n0v]] – yEF<BR />
**[[1u2r]] – yEF + GDP<BR />
**[[1u2r]] – yEF + GDP<BR />
**[[1n0u]], [[2e1r]], [[2npf]] – yEF + antifungal drug<BR />
**[[1n0u]], [[2e1r]], [[2npf]] – yEF + antifungal drug<BR />
**[[1zm2]], [[1zm3]], [[1zm4]], [[1zm9]], [[3b78]], [[3b82]], [[3b8h]], [[2zit]] – yEF + exotoxin<BR />
**[[1zm2]], [[1zm3]], [[1zm4]], [[1zm9]], [[3b78]], [[3b82]], [[3b8h]], [[2zit]] – yEF + exotoxin<BR />
-
**[[2p8w]], [[2p8x]], [[3dny]] - yEF in 80S ribosome – Cryo EM<BR />
+
**[[2p8w]], [[2p8x]], [[3dny]], [[6gqb]], [[6gqv]] - yEF in 80S ribosome – Cryo EM<BR />
-
**[[2p8y]], [[2p8z]] - yEF+ antifungal drug in 80S ribosome – Cryo EM<BR />
+
**[[2p8y]], [[2p8z]], [[5juo]]- yEF+ antifungal drug in 80S ribosome – Cryo EM<BR />
**[[5h7j]] - PhEF <BR />
**[[5h7j]] - PhEF <BR />
**[[5h7l]] - PhEF + L12<BR />
**[[5h7l]] - PhEF + L12<BR />
Line 190: Line 250:
**[[6u45]] – MnEF + GMPPCP – ''Methanoperedens nitroreducens'' <BR />
**[[6u45]] – MnEF + GMPPCP – ''Methanoperedens nitroreducens'' <BR />
**[[6u43]], [[6u44]] – MnEF (mutant) + GMPPCP <BR />
**[[6u43]], [[6u44]] – MnEF (mutant) + GMPPCP <BR />
 +
**[[6q2d]] - EF + DPH2 – ''Methanobrevibacter smithii''<BR />
*EF-3
*EF-3
Line 196: Line 257:
**[[2iwh]] – yEF + ADPNP<BR />
**[[2iwh]] – yEF + ADPNP<BR />
**[[2iw3]] – yEF + ADP<BR />
**[[2iw3]] – yEF + ADP<BR />
-
**[[2ix8]] – yEF in 80S ribosome – Cryo EM<BR />
+
**[[2ix8]], [[7b7d]] – yEF in 80S ribosome – Cryo EM<BR />
*EF-4 (lepA)
*EF-4 (lepA)
Line 202: Line 263:
**[[2ywh]], [[2ywe]], [[2ywf]], [[2ywg]] - AalepA + nucleotide - ''Aquifex aeolicus''<BR />
**[[2ywh]], [[2ywe]], [[2ywf]], [[2ywg]] - AalepA + nucleotide - ''Aquifex aeolicus''<BR />
**[[3cb4]] - EclepA <BR />
**[[3cb4]] - EclepA <BR />
-
**[[3deg]] - EclepA in 70S ribosome + GMPPNP – Cryo EM<BR />
+
**[[3deg]], [[3jcd]], [[3jce]] - EclepA in 70S ribosome + GMPPNP – Cryo EM<BR />
 +
**[[5j8b]] - TtlepA in 70S ribosome + GDPCP <BR />
 +
**[[4w2e]] - TtlepA in 70S ribosome <BR />
*EF-SelB
*EF-SelB
Line 220: Line 283:
**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />
**[[3h7h]] – hEF-Spt4 residues 2-117 + hEF-Spt5 residues 176-273<br />
 +
**[[8p4d]], [[8p4f]], [[8w8f]] – hEF-Spt4 + EF-Spt5 in transcription complex – Cryo EM<br />
 +
**[[7wbv]], [[7wbw]], [[7wbx]], [[9j0o]] – hEF-Spt4 + EF-Spt5 + EF-1-homolog in transcription complex + nucleosome – Cryo EM<br />
**[[6gmh]], [[6gml]] – hEF-Spt4 + EF-Spt5 + EF-Spt6 in transcription complex – Cryo EM<br />
**[[6gmh]], [[6gml]] – hEF-Spt4 + EF-Spt5 + EF-Spt6 in transcription complex – Cryo EM<br />
 +
**[[8xrm]] – hEF-Spt4 + EF-Spt5 + EF-Spt6 + EF-1-homolog in RNA polymerase II elongation complex - CryoEM<br />
**[[5oik]] – bEF-Spt4 + EF-Spt5 + RNA polymerase II <br />
**[[5oik]] – bEF-Spt4 + EF-Spt5 + RNA polymerase II <br />
 +
**[[7nkx]], [[7nky]] – yEF-Spt4 + EF-Spt5 + EF-Spt16 in RNA polymerase II elongation complex - CryoEM<br />
 +
**[[8ram]], [[8rap]] – yEF-Spt4 + EF-Spt5 + EF-1 in RNA polymerase II elongation complex - CryoEM<br />
**[[2exu]] – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375<br />
**[[2exu]] – yEF-Spt4 residues 1-99 + EF-Spt5 residues 285-375<br />
**[[4zn3]], [[4zn1]] – EF-Spt4 + EF-Spt5 – ''Methanocaldococcus jannaschii'' <br />
**[[4zn3]], [[4zn1]] – EF-Spt4 + EF-Spt5 – ''Methanocaldococcus jannaschii'' <br />
-
**[[5xon]], [[5xog]], [[6ir9]], [[6j4w]], [[6j4x]], [[6j4y]], [[6j4z]], [[6j50]], [[6j51]] – EF-Spt4 + EF-Spt5 + EF-Tfiis in RNA polymerase II elongation complex - ''Komagataella phaffii'' - Cryo EM<br />
+
**[[8p2i]] – PhEF-Spt4 + EF-Spt5 in RNA polymerase II elongation complex - CryoEM<br />
 +
**[[8oki]] – PfEF-Spt4 + EF-Spt5 in RNA polymerase II elongation complex - CryoEM<br />
 +
**[[5xon]], [[5xog]], [[6ir9]], [[6j4w]], [[6j4x]], [[6j4y]], [[6j4z]], [[6j50]], [[6j51]], [[8he5]], [[8jh2]] – EF-Spt4 + EF-Spt5 + EF-11 homolog in RNA polymerase II elongation complex - ''Komagataella phaffii'' - Cryo EM<br />
 +
**[[9bct]], [[9bcu]] – EF-Spt4 + EF-Spt5 + EF-FTTA in RNA polymerase II elongation complex – ''Thermococcus kodakarensis'' - CryoEM<br />
*EF-Spt5
*EF-Spt5
 +
**[[8p4c]], [[8p4e]], [[8uis]] – hEF-Spt5 in transcription complex – Cryo EM<br />
**[[2e6z]] – hEF KOW2 motif residues 420-471 – NMR<BR />
**[[2e6z]] – hEF KOW2 motif residues 420-471 – NMR<BR />
**[[2do3]] – hEF KOW3 motif residues 462-523 – NMR<BR />
**[[2do3]] – hEF KOW3 motif residues 462-523 – NMR<BR />
Line 236: Line 308:
**[[5ohq]] – hEF KOW6-KOW7 domain residues 939-1087<br />
**[[5ohq]] – hEF KOW6-KOW7 domain residues 939-1087<br />
**[[5oho]] – hEF KOWX-KOW4 domain residues 536-646<br />
**[[5oho]] – hEF KOWX-KOW4 domain residues 536-646<br />
 +
**[[7okx]], [[7ol0]] – pEF-Spt5 in RNA polymerase II transcription complex – Cryo EM<br />
**[[4ytl]] – yEF KOW2-KOW3 domain residues 534-632<br />
**[[4ytl]] – yEF KOW2-KOW3 domain residues 534-632<br />
**[[4ytk]] – yEF KOW1-linker domain residues 382-511<br />
**[[4ytk]] – yEF KOW1-linker domain residues 382-511<br />
 +
**[[8jch]] – yEF in POL II complex – Cryo EM<br />
 +
**[[8k5p]] – yEF in POL II complex + Rai1 – Cryo EM<br />
 +
**[[8qsz]] – EF in POL II complex – fission yeast - Cryo EM<br />
 +
**[[2exu]] – yEF<BR />
**[[2exu]] – yEF<BR />
Line 245: Line 322:
**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />
**[[4z2m]] – hEF middle domain + histone H3.1 + histone H4<br />
**[[6gme]] – hEF SH2 domain residues 1317-1334<br />
**[[6gme]] – hEF SH2 domain residues 1317-1334<br />
 +
**[[7oop]], [[7opc]], [[7opd]], [[8oeu]], [[8oev]], [[8of0]] – hEF-Spt6 in RNA polymerase II transcription complex – Cryo EM<br />
 +
**[[6ted]], [[7unc]], [[7und]] – pEF in RNA polymerase II transcription complex - CryoEM<br />
**[[3psf]], [[3psi]] – yEF core domain residues 235-1259<BR />
**[[3psf]], [[3psi]] – yEF core domain residues 235-1259<BR />
**[[3psj]], [[3psk]] – yEF SH2 domain residues 1247-1451<BR />
**[[3psj]], [[3psk]] – yEF SH2 domain residues 1247-1451<BR />
Line 251: Line 330:
**[[3oak]] – yEF + transcription factor IWS1<br />
**[[3oak]] – yEF + transcription factor IWS1<br />
**[[3gxw]], [[3gxx]], [[3pjp]] – EF SH2 domain – ''Candida glabrata''<BR />
**[[3gxw]], [[3gxx]], [[3pjp]] – EF SH2 domain – ''Candida glabrata''<BR />
 +
**[[6qtc]] – CgEF SH2 domain + Tyr phosphorylated CTD – NMR <br />
 +
**[[2xp1]] – EF SH2 domain – ''Antonospora locustae'' <br />
*EF-Spt16
*EF-Spt16
Line 256: Line 337:
**[[5umu]], [[5umt]], [[5xm2]] – hEF<br />
**[[5umu]], [[5umt]], [[5xm2]] – hEF<br />
**[[5e5b]] - hEF N-terminal<BR />
**[[5e5b]] - hEF N-terminal<BR />
 +
**[[8i17]] - hEF + histone 2A + histone 2B<BR />
*EF-M2-1
*EF-M2-1
Line 266: Line 348:
**[[5ol8]] - hEF C-terminal<br />
**[[5ol8]] - hEF C-terminal<br />
**[[5ola]] - hEF + RNA polymerase + RNA + DNA<br />
**[[5ola]] - hEF + RNA polymerase + RNA + DNA<br />
 +
**[[8u8u]], [[8u8v]], [[9bdc]], [[9bdd]] - hEF + RNA polymerase + RNA + DNA – Cryo EM<br />
*EF-CA150
*EF-CA150
Line 276: Line 359:
**[[4hfx]] – hEloA F-box domain<br />
**[[4hfx]] – hEloA F-box domain<br />
 +
**[[6zuz]] – hEloA N-terminal<br />
*Elongin C
*Elongin C
Line 284: Line 368:
*Elongin BC complex
*Elongin BC complex
-
**[[1lqb]], [[1lm8]] – hEloBC + von-Hippel Lindau disease tumor suppressor + hypoxia inducible factor 1 α<br />
+
**[[1vcb]], [[8bdi]], [[8bdj]] – hEloBC + VHL<br />
-
**[[6i7q]], [[6i7r]] – hEloBC + von-Hippel Lindau disease tumor suppressor + hypoxia inducible factor 2 α<br />
+
**[[8ei3]] – hEloBC + VHL + peptide<br />
-
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]], [[6fmi]], [[6fmj]], [[6fmk]], [[5nw2]], [[5nw1]], [[5nw0]], [[5nvz]], [[5nvy]], [[5nvx]], [[5nvw]], [[5nvv]], [[4w9l]], [[4w9k]], [[4w9j]], [[4w9i]], [[4w9h]], [[4w9g]], [[4w9f]], [[4w9e]], [[4w9d]], [[4w9c]], [[6gfy]] - hEloBC + von-Hippel Lindau disease tumor suppressor + inhibitor<br />
+
**[[1lqb]], [[1lm8]] – hEloBC + VHL + hypoxia inducible factor 1 α<br />
-
**[[5t35]], [[6sis]] - hEloBC + von-Hippel Lindau disease tumor suppressor + BRD4<br />
+
**[[6i7q]], [[6i7r]] – hEloBC + VHL + hypoxia inducible factor 2 α<br />
-
**[[4wqo]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 <br />
+
**[[7q2j]], [[8bb2]], [[8bb3]], [[8bb4]], [[8bb5]] – hEloBC + VHL + WD repeat-containing protein 5<br />
-
**[[6hr2]], [[6hay]], [[6hax]] - hEloBC + von-Hippel Lindau disease tumor suppressor + transcription activator <br />
+
**[[7jto]], [[7jtp]] – hEloBC + VHL + WD repeat-containing protein 5 + inhibitor<br />
-
**[[6gmr]], [[6gfx]], [[6bvb]] - hEloBC + von-Hippel Lindau disease tumor suppressor + hypoxia inducible factor peptide <br />
+
**[[7znt]], [[8bdx]] – hEloBC + VHL + BRD4<br />
 +
**[[8beb]], [[8ewv]] – hEloBC + VHL + BRD4 + ligand<br />
 +
**[[8pc2]] – hEloBC + VHL + FKBP5<br />
 +
**[[8fy0]], [[8fy1]], [[8fy2]] – hEloBC + VHL + Bcl-2<br />
 +
**[[3zrc]], [[3ztc]], [[3ztd]], [[3zun]], [[4awj]], [[4b95]], [[4b9k]], [[4bks]], [[4bkt]], [[4w9l]], [[4w9k]], [[4w9j]], [[4w9i]], [[4w9h]], [[4w9g]], [[4w9f]], [[4w9e]], [[4w9d]], [[4w9c]], [[5nw2]], [[5nw1]], [[5nw0]], [[5nvz]], [[5nvy]], [[5nvx]], [[5nvw]], [[5nvv]], [[6fmi]], [[6fmj]], [[6fmk]], [[6gfy]], [[8bdl]], [[8bdm]], [[8bdn]], [[8bdo]], [[8c13]], [[8cqe]], [[8cqk]], [[8cql]], [[8p0f]], [[8qjs]], [[8zvj]], [[9bju]], [[9bol]], [[9gio]], [[9ipw]] - hEloBC + VHL + inhibitor<br />
 +
**[[5t35]], [[6sis]] - hEloBC + VHL + BRD4<br />
 +
**[[8qvu]] - hEloBC + VHL + Kras <br />
 +
**[[8qw6]], [[8qw7]] - hEloBC + VHL + Kras + inhibitor<br />
 +
**[[7khh]], [[8bdt]] - hEloBC + VHL + BRD4 + inhibitor<br />
 +
**[[8bds]] - hEloBC + VHL + BRD4 + inhibitor – Cryo EM<br />
 +
**[[7s4e]], [[7z6l]], [[7z76]], [[7z77]], [[8g1q]] - hEloBC + VHL + SMARCA2 + inhibitor<br /
 +
**[[4wqo]] - hEloBC + VHL + cullin-2 <br />
 +
**[[6hr2]], [[6hay]], [[6hax]] - hEloBC + VHL + transcription activator <br />
 +
**[[8qjr]] - hEloBC + VHL + transcription activator + inhibitor <br />
 +
**[[4ajy]] - hEloBC + hypoxia inducible factor peptide <br />
 +
**[[6gmr]], [[6gfx]], [[6bvb]] - hEloBC + VHL + hypoxia inducible factor peptide <br />
 +
**[[8ebn]] - hEloBC + kelch domain-containing protein<br />
 +
**[[8sh2]] - hEloBC + kelch domain-containing protein – Cryo EM<br />
 +
**[[9d1i]], [[9d1y]], [[9d1z]] - hEloBC + ubiquitin + kelch domain-containing protein<br />
**[[5n4w]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1<br />
**[[5n4w]] - hEloBC + von-Hippel Lindau disease tumor suppressor + cullin-2 + RBX1<br />
-
**[[3zrf]], [[5lli]], [[6gmx]], [[6gmq]], [[6gmn]], [[6gfz]] - hEloBC + von-Hippel Lindau disease tumor suppressor<br />
+
**[[8ij1]], [[8wqg]], [[9j77]], [[9j78]] - hEloBC + cullin-2 + RBX1 + FEM-1 – Cryo EM<br />
 +
**[[9j79]] - hEloBC + cullin-2 + RBX1 + FEM-1 + TOM20 – Cryo EM<br />
 +
**[[9lky]] - hEloBC + cullin-2 + RBX1 + FEM-1 + choline phosphatase – Cryo EM<br />
 +
**[[8jas]], [[8jau]], [[8jav]], [[8wqa]], [[8wqb]], [[8wqe]], [[8wqf]], [[8wqh]] - hEloBC + cullin-2 + RBX1 + FEM-1 + C-degron – Cryo EM<br />
 +
**[[8jaq]], [[8jar]] - hEloBC + cullin-2 + RBX1 + APP + C-degron – Cryo EM<br />
 +
**[[8je2]] - hEloBC + cullin-2 + folliculin-interacting protein + FEM-1 – Cryo EM<br />
 +
**[[8je1]] - hEloBC + cullin-2 + BEX2 + FEM-1 – Cryo EM<br />
 +
**[[8rwz]] - hEloBC + cullin-2 + RBX1 + BRD4 – Cryo EM<br />
 +
**[[8wdk]] - hEloBC + VHL + cullin-2 + RBX1 + Wee – Cryo EM<br />
 +
**[[8qu8]] - hEloBC + VHL + cullin-2 + RBX1 + Kras – Cryo EM<br />
 +
**[[8q7r]] - hEloBC + cullin-2 + RBX1 + FEM-1 + ubiquitin + Nedd8 – Cryo EM<br />
 +
**[[8r5h]] - hEloBC + cullin-2 + RBX1 + BRD4 + ubiquitin + ubiquitin conjugating enzyme – Cryo EM<br />
 +
**[[8pql]] - hEloBC + cullin-2 + RBX1 + FEM-1 + polyubiquitin + ubiquitin conjugating enzyme E2 – Cryo EM<br />
 +
**[[8rx0]] - hEloBC + cullin-2 + RBX1 + CDC34 + ubiquitin + Nedd8 – Cryo EM<br />
 +
**[[8ol1]] - hEloBC + nucleosome + cGAMP synthase + SSB-3 – Cryo EM<br />
 +
**[[4n9f]] - hEloBC + VIF+ cullin-5 + CBF<br />
 +
**[[2ma9]] - hEloBC + VIF - NMR<br />
 +
**[[3zrf]], [[5lli]], [[6gmx]], [[6gmq]], [[6gmn]], [[6gfz]] - hEloBC + VHL<br />
 +
**[[8vlb]] - hEloBC + VHL + CDO
 +
**[[8vl9]] - hEloBC + VHL + CDO + molecular glue
 +
**[[6zhc]] - hEloBC + VHL + Bcl-2-like protein<br />
**[[2c9w]], [[2izv]], [[2jz3]], [[5bo4]] – hEloBC + suppressor of cytokine signaling<br />
**[[2c9w]], [[2izv]], [[2jz3]], [[5bo4]] – hEloBC + suppressor of cytokine signaling<br />
-
**[[6c5x]] – hEloBC + suppressor of cytokine signaling + Gp130 peptide<br />
+
**[[6c5x]], [[6i4x]], [[6i5n]], [[6i5j]] [[7m6t]] – hEloBC + suppressor of cytokine signaling + Gp130 peptide<br />
 +
**[[7zlm]], [[7zln]], [[7zlo]], [[7zlp]], [[7zlr]], [[7zls]] – hEloBC + suppressor of cytokine signaling + ligand<br />
**[[6i5n]], [[6i5j]] – hEloBC + suppressor of cytokine signaling + growth hormone receptor peptide<br />
**[[6i5n]], [[6i5j]] – hEloBC + suppressor of cytokine signaling + growth hormone receptor peptide<br />
**[[6i4x]] – hEloBC + suppressor of cytokine signaling + erythropoietin peptide<br />
**[[6i4x]] – hEloBC + suppressor of cytokine signaling + erythropoietin peptide<br />
**[[6p59]] - hEloBC + virion infectivity factor + CBF b<br />
**[[6p59]] - hEloBC + virion infectivity factor + CBF b<br />
 +
**[[8fvi]], [[8fvj]] - hEloBC + virion infectivity factor + CBF beta – Cryo EM<br />
 +
**[[7upn]] - hEloBC + virion infectivity factor + Ppiase – Cryo EM<br />
 +
**[[8cx0]], [[8cx1]], [[8cx2]] - hEloBC + APOBEC + virion infectivity factor + CBF b + RNA – Cryo EM<br />
 +
**[[8szk]] - hEloBC + PP2A+ virion infectivity factor + CBF b + RNA – Cryo EM<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />
**[[3zkj]] - hEloBC + ankyrin rep<br />
-
**[[1vcb]] – hEloBC + VHL<br />
+
**[[8y1u]] - hEloBC + ankyrin repeat + LZTS1 degron
 +
**[[3zng]] – hEloBC + ASB-9 <br />
**[[6v9h]] – hEloBC + creatine kinase + ASB-9 – Cryo EM<br />
**[[6v9h]] – hEloBC + creatine kinase + ASB-9 – Cryo EM<br />
 +
**[[6r6h]], [[6r7f]], [[6r7h]], [[6r7i]], [[6r7n]] – hEloBC in signalosome – Cryo EM<br />
 +
**[[9d8p]] – hEloBC + kelch domain-containing protein + ubiquitin – Cryo EM<br />
**[[2fnj]] - mEloBC + GUSTAVUS
**[[2fnj]] - mEloBC + GUSTAVUS
 +
 +
*Elongin ABC complex
 +
 +
**[[8oew]] – hEloABC + RNA Pol II + RNA + DNA – Cryo EM<br />
 +
 +
*Negative EF
 +
 +
**[[1x5p]], [[2bz2]], [[2jx2]] – hNELF-E RRM domain - NMR<br />
 +
**[[5l3x]] – hNELF-A + hNELF-C/D <br />
 +
**[[8jj6]] – hNELF-B + hNELF-C/D + hNELF-E <br />
 +
**[[6gml]], [[8uha]], [[8uhd]], [[8uhg]], [[8uis]] – hNELF-F in Pol II complex – Cryo EM <br />
 +
**[[8ui0]], [[8w8e]] – hNELF-A + hNELF-B + hNELF-C/D + hNELF-E in Pol II complex – Cryo EM <br />
 +
**[[8uhg]] – hNELF-A + hNELF-B + hNELF-C/D + hNELF-E + Spt5 in Pol II complex – Cryo EM <br />
 +
**[[8rbx]], [[9j0n]], [[9j0o]], [[9j0p]] – hNELF-A + hNELF-B + hNELF-C/D + hNELF-E in Pol II complex + nucleosome – Cryo EM <br />
 +
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D structures of elongation factor

Updated on 21-May-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Jaime Prilusky, Joel L. Sussman

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