6t4k
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand MRL871== | |
| - | + | <StructureSection load='6t4k' size='340' side='right'caption='[[6t4k]], [[Resolution|resolution]] 1.89Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6t4k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T4K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T4K FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.89Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4F1:4-{1-[2-CHLORO-6-(TRIFLUOROMETHYL)BENZOYL]-1H-INDAZOL-3-YL}BENZOIC+ACID'>4F1</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MHQ:desmosterol'>MHQ</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t4k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t4k OCA], [https://pdbe.org/6t4k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t4k RCSB], [https://www.ebi.ac.uk/pdbsum/6t4k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t4k ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brunsveld L]] | ||
| + | [[Category: Meijer FA]] | ||
| + | [[Category: De Vries RMJM]] | ||
Current revision
ROR(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand MRL871
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