6z2t
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Three-dimensional structure of an influenza hemagglutinin LAH protein in its post-fusion conformation== | |
| + | <StructureSection load='6z2t' size='340' side='right'caption='[[6z2t]], [[Resolution|resolution]] 1.34Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6z2t]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Mexico_City/63/2009(H1N1)) Influenza A virus (A/Mexico City/63/2009(H1N1))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z2T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z2T FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z2t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z2t OCA], [https://pdbe.org/6z2t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z2t RCSB], [https://www.ebi.ac.uk/pdbsum/6z2t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z2t ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/C6KNC6_9INFA C6KNC6_9INFA] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.[RuleBase:RU003324] | ||
| - | + | ==See Also== | |
| - | + | *[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Kazaks | + | [[Category: Large Structures]] |
| - | [[Category: Kirsteina | + | [[Category: Kazaks A]] |
| - | [[Category: Tars | + | [[Category: Kirsteina A]] |
| + | [[Category: Tars K]] | ||
Current revision
Three-dimensional structure of an influenza hemagglutinin LAH protein in its post-fusion conformation
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