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6zre

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(New page: '''Unreleased structure''' The entry 6zre is ON HOLD Authors: Ntsogo Enguene, Y.V., Monlezun, L., Ma, M., Garnier, C., Lascombe, M.B., Salem, M., Guenard, S., Plesiat, P., Llanes, C., P...)
Current revision (11:57, 1 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 6zre is ON HOLD
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==Deciphering the role of the channel constrictions in the opening mechanism of MexAB-OprM efflux pump from Pseudomonas aeruginosa==
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<StructureSection load='6zre' size='340' side='right'caption='[[6zre]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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Authors: Ntsogo Enguene, Y.V., Monlezun, L., Ma, M., Garnier, C., Lascombe, M.B., Salem, M., Guenard, S., Plesiat, P., Llanes, C., Phan, G., Broutin, I.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6zre]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZRE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZRE FirstGlance]. <br>
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Description: Deciphering the role of the channel constrictions in the opening mechanism of MexAB-OprM efflux pump from Pseudomonas aeruginosa
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Salem, M]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zre FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zre OCA], [https://pdbe.org/6zre PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zre RCSB], [https://www.ebi.ac.uk/pdbsum/6zre PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zre ProSAT]</span></td></tr>
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[[Category: Llanes, C]]
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</table>
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[[Category: Phan, G]]
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== Function ==
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[[Category: Garnier, C]]
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[https://www.uniprot.org/uniprot/OPRM_PSEAE OPRM_PSEAE] The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane component for the MexXY efflux system. Implicated in the secretion of the siderophore pyoverdine. OprM is probably involved in the efflux of the siderophore across the outer membrane.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9401051</ref> <ref>PMID:9603892</ref> <ref>PMID:10952562</ref> The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the MexB subunit is a proton antiporter.<ref>PMID:8226684</ref> <ref>PMID:8540696</ref> <ref>PMID:9401051</ref> <ref>PMID:9603892</ref> <ref>PMID:10952562</ref>
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[[Category: Plesiat, P]]
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== References ==
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[[Category: Guenard, S]]
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<references/>
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[[Category: Ntsogo Enguene, Y.V]]
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__TOC__
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[[Category: Monlezun, L]]
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</StructureSection>
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[[Category: Lascombe, M.B]]
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[[Category: Large Structures]]
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[[Category: Ma, M]]
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[[Category: Pseudomonas aeruginosa PAO1]]
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[[Category: Broutin, I]]
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[[Category: Broutin I]]
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[[Category: Garnier C]]
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[[Category: Guenard S]]
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[[Category: Lascombe MB]]
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[[Category: Llanes C]]
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[[Category: Ma M]]
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[[Category: Monlezun L]]
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[[Category: Ntsogo Enguene YV]]
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[[Category: Phan G]]
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[[Category: Plesiat P]]
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[[Category: Salem M]]

Current revision

Deciphering the role of the channel constrictions in the opening mechanism of MexAB-OprM efflux pump from Pseudomonas aeruginosa

PDB ID 6zre

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