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Ephrin
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>. See also [[Ephrin receptor]] | + | '''Ephrins''' (Eph) are the membrane-bound ligands of ephrin receptors. The binding of Eph and ephrin receptors is achieved via cell-cell interaction. Eph/Eph receptor signaling regulates embryonic development, guidance of axon growth, long-term potentiation, angiogenesis and stem-cell differentiation <ref>PMID:17420126</ref>. See also [[Ephrin receptor]], [[Eph/ephrin signaling pathway]], [[Ephrin Type-A Receptor]]. |
== Disease == | == Disease == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
{{#tree:id=OrganizedByTopic|openlevels=0| | {{#tree:id=OrganizedByTopic|openlevels=0| | ||
| + | |||
| + | *Ephrin-A1 | ||
| + | |||
| + | **[[3hei]], [[3mbw]], [[3czu]] – hEph receptor-binding domain + Eph type A receptor 2 <br /> | ||
| + | **[[3fl7]] – hEph ectodomain <br /> | ||
| + | |||
| + | *Ephrin-A2 | ||
| + | |||
| + | **[[2wo3]] – hEph receptor-binding domain + Eph type A receptor 4 <br /> | ||
| + | |||
| + | * Ephrin-A3 | ||
| + | |||
| + | **[[3dzq]] – hEph kinase domain + inhibitor <br /> | ||
*Ephrin-A5 | *Ephrin-A5 | ||
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**[[4uf7]], [[6pdl]] – hEph extracellular domain + glycoprotein <br /> | **[[4uf7]], [[6pdl]] – hEph extracellular domain + glycoprotein <br /> | ||
**[[2vsk]], [[2vsm]] – hEph extracellular domain + virus hemagglutinin neuraminidase <br /> | **[[2vsk]], [[2vsm]] – hEph extracellular domain + virus hemagglutinin neuraminidase <br /> | ||
| - | **[[1iko]] – mEph ectodomain <br /> | + | **[[1iko]], [[7s7k]] – mEph ectodomain <br /> |
**[[1kgy]] – mEph extracellular domain + Eph type B receptor 2 <br /> | **[[1kgy]] – mEph extracellular domain + Eph type B receptor 2 <br /> | ||
**[[2hle]] – mEph extracellular domain + Eph type B receptor 4 <br /> | **[[2hle]] – mEph extracellular domain + Eph type B receptor 4 <br /> | ||
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**[[4bkf]] – hEph receptor-binding domain + Eph type A receptor 4 <br /> | **[[4bkf]] – hEph receptor-binding domain + Eph type A receptor 4 <br /> | ||
**[[3d12]] – mEph receptor-binding domain + virus hemagglutinin neuraminidase <br /> | **[[3d12]] – mEph receptor-binding domain + virus hemagglutinin neuraminidase <br /> | ||
| - | |||
| - | *Ephrin-A1 | ||
| - | |||
| - | **[[3hei]], [[3mbw]], [[3czu]] – hEph receptor-binding domain + Eph type A receptor 2 <br /> | ||
| - | **[[3fl7]] – hEph ectodomain <br /> | ||
| - | |||
| - | *Ephrin-A2 | ||
| - | |||
| - | **[[2wo3]] – hEph receptor-binding domain + Eph type A receptor 4 <br /> | ||
| - | |||
| - | * Ephrin-A3 | ||
| - | |||
| - | **[[3dzq]] – hEph kinase domain + inhibitor <br /> | ||
}} | }} | ||
Current revision
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3D structures of ephrin
Updated on 21-February-2023
References
- ↑ Egea J, Klein R. Bidirectional Eph-ephrin signaling during axon guidance. Trends Cell Biol. 2007 May;17(5):230-8. Epub 2007 Apr 8. PMID:17420126 doi:http://dx.doi.org/10.1016/j.tcb.2007.03.004
- ↑ Himanen JP, Yermekbayeva L, Janes PW, Walker JR, Xu K, Atapattu L, Rajashankar KR, Mensinga A, Lackmann M, Nikolov DB, Dhe-Paganon S. Architecture of Eph receptor clusters. Proc Natl Acad Sci U S A. 2010 May 26. PMID:20505120
