6s40

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<StructureSection load='6s40' size='340' side='right'caption='[[6s40]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='6s40' size='340' side='right'caption='[[6s40]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6s40]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S40 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6S40 FirstGlance]. <br>
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S40 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S40 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KTW:4-chloranyl-1-benzothiophene-2-carboximidamide'>KTW</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=KTW:4-chloranyl-1-benzothiophene-2-carboximidamide'>KTW</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s40 OCA], [https://pdbe.org/6s40 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s40 RCSB], [https://www.ebi.ac.uk/pdbsum/6s40 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s40 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6s40 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s40 OCA], [http://pdbe.org/6s40 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6s40 RCSB], [http://www.ebi.ac.uk/pdbsum/6s40 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6s40 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
 
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[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6s40" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6s40" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Castaldi, P]]
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[[Category: Castaldi P]]
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[[Category: Genet, S]]
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[[Category: Genet S]]
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[[Category: Guillory, X]]
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[[Category: Guillory X]]
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[[Category: Leysen, S]]
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[[Category: Leysen S]]
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[[Category: Ottmann, C]]
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[[Category: Ottmann C]]
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[[Category: Patel, J]]
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[[Category: Patel J]]
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[[Category: Somsen, B]]
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[[Category: Somsen B]]
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[[Category: Wolter, M]]
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[[Category: Wolter M]]
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[[Category: Fragment soaking]]
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[[Category: Peptide binding protein]]
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[[Category: Protein protein interaction]]
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[[Category: Stabilization]]
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Current revision

Fragment AZ-001 binding at the p53pT387/14-3-3 sigma interface and additional sites

PDB ID 6s40

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