6slw

<table><tr><td colspan='2'>[[6slw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SLW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6SLW FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L1T:4-methyl-5-phenyl-thiophene-2-carboximidamide'>L1T</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6rhc|6rhc]]</td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SFN, HME1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6slw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6slw OCA], [http://pdbe.org/6slw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6slw RCSB], [http://www.ebi.ac.uk/pdbsum/6slw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6slw ProSAT]</span></td></tr>

== Disease ==

[[http://www.uniprot.org/uniprot/WWTR1_HUMAN WWTR1_HUMAN]] Epithelioid hemangioendothelioma.

== Function ==

[[http://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN]] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. [[http://www.uniprot.org/uniprot/WWTR1_HUMAN WWTR1_HUMAN]] Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition.<ref>PMID:11118213</ref> <ref>PMID:18227151</ref> <ref>PMID:18568018</ref> <ref>PMID:19010321</ref>

[[Category: Human]]

[[Category: Castaldi, P]]

[[Category: Genet, S]]

[[Category: Guillory, X]]

[[Category: Leysen, S]]

[[Category: Ottmann, C]]

[[Category: Patel, J]]

[[Category: Somsen, B]]

[[Category: Wolter, M]]

[[Category: Stabilization]]