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2y5l

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<StructureSection load='2y5l' size='340' side='right'caption='[[2y5l]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2y5l' size='340' side='right'caption='[[2y5l]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2y5l]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5L OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2Y5L FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2y5l]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y5L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y5L FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO8:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-3-CHLOROBENZENESULFONAMIDE'>RO8</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2jjk|2jjk]], [[2wbd|2wbd]], [[2fhy|2fhy]], [[2fix|2fix]], [[1fta|1fta]], [[2vt5|2vt5]], [[2fie|2fie]], [[2wbb|2wbb]], [[2y5k|2y5k]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RO8:N-{[(2Z)-5-BROMO-1,3-THIAZOL-2(3H)-YLIDENE]CARBAMOYL}-3-CHLOROBENZENESULFONAMIDE'>RO8</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Fructose-bisphosphatase Fructose-bisphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.11 3.1.3.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5l OCA], [https://pdbe.org/2y5l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y5l RCSB], [https://www.ebi.ac.uk/pdbsum/2y5l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y5l ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2y5l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y5l OCA], [http://pdbe.org/2y5l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2y5l RCSB], [http://www.ebi.ac.uk/pdbsum/2y5l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2y5l ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[http://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[http://omim.org/entry/229700 229700]]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fructose-bisphosphatase]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Alvarez-sanchez, r]]
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[[Category: Alvarez-sanchez r]]
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[[Category: Benardeau, a]]
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[[Category: Benardeau a]]
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[[Category: Benz, j]]
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[[Category: Benz j]]
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[[Category: Gubler, m]]
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[[Category: Gubler m]]
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[[Category: Haap, w]]
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[[Category: Haap w]]
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[[Category: Hebeisen, p]]
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[[Category: Hebeisen p]]
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[[Category: Joseph, c]]
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[[Category: Joseph c]]
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[[Category: Kirchner, s]]
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[[Category: Kirchner s]]
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[[Category: Kitas, e]]
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[[Category: Kitas e]]
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[[Category: Kuhn, b]]
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[[Category: Kuhn b]]
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[[Category: Mohr, p]]
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[[Category: Mohr p]]
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[[Category: Ruf, a]]
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[[Category: Ruf a]]
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[[Category: Schott, b]]
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[[Category: Schott b]]
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[[Category: Tozzo, e]]
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[[Category: Tozzo e]]
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[[Category: Wessel, h p]]
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[[Category: Wessel hp]]
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[[Category: Zutter, u]]
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[[Category: Zutter u]]
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[[Category: Hydrolase]]
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Current revision

orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase

PDB ID 2y5l

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