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| | <StructureSection load='2yoq' size='340' side='right'caption='[[2yoq]], [[Resolution|resolution]] 2.35Å' scene=''> | | <StructureSection load='2yoq' size='340' side='right'caption='[[2yoq]], [[Resolution|resolution]] 2.35Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2yoq]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOQ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2YOQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2yoq]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YOQ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.35Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yop|2yop]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2yoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoq OCA], [http://pdbe.org/2yoq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yoq RCSB], [http://www.ebi.ac.uk/pdbsum/2yoq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoq ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yoq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yoq OCA], [https://pdbe.org/2yoq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yoq RCSB], [https://www.ebi.ac.uk/pdbsum/2yoq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yoq ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/FAM3B_MOUSE FAM3B_MOUSE]] Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.<ref>PMID:23333428</ref> | + | [https://www.uniprot.org/uniprot/FAM3B_MOUSE FAM3B_MOUSE] Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.<ref>PMID:23333428</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Lk3 transgenic mice]] | + | [[Category: Mus musculus]] |
| - | [[Category: Backstrom, S]] | + | [[Category: Backstrom S]] |
| - | [[Category: Bernstrom, J]] | + | [[Category: Bernstrom J]] |
| - | [[Category: Gorman, T]] | + | [[Category: Gorman T]] |
| - | [[Category: Johansson, P]] | + | [[Category: Holmberg Schiavone L]] |
| - | [[Category: Oster, L]] | + | [[Category: Johansson P]] |
| - | [[Category: Schiavone, L Holmberg]] | + | [[Category: Oster L]] |
| - | [[Category: Schweikart, F]] | + | [[Category: Schweikart F]] |
| - | [[Category: Xu, B]] | + | [[Category: Xu B]] |
| - | [[Category: Xue, Y]] | + | [[Category: Xue Y]] |
| - | [[Category: Apoptosis]]
| + | |
| - | [[Category: Diabetes]]
| + | |
| - | [[Category: Emt]]
| + | |
| - | [[Category: Ilei]]
| + | |
| Structural highlights
Function
FAM3B_MOUSE Induces apoptosis of alpha and beta cells in a dose- and time-dependent manner.[1]
Publication Abstract from PubMed
The FAM3 superfamily is predicted to contain classical four-helix bundle cytokines, featuring a typical up-up-down-down fold. Two members of FAM3 have been extensively studied. FAM3B PANDER has been shown to regulate glucose homeostasis and beta cell function, whereas the homologous FAM3C ILEI has been shown to be involved in epithelial-mesenchymal transition and cancer. Here, we present a three-dimensional structure of a FAM3 protein, murine PANDER. Contrary to previous suggestions, PANDER exhibits a globular beta-beta-alpha fold. The structure is composed of two antiparallel beta sheets lined by three short helices packing to form a highly conserved water-filled cavity. The fold shares no relation to the predicted four-helix cytokines but is conserved throughout the FAM3 superfamily. The available biological data and the unexpected new fold indicate that FAM3 PANDER and ILEI could represent a new structural class of signaling molecules, with a different mode of action compared to the traditional four-helix bundle cytokines.
FAM3B PANDER and FAM3C ILEI Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-like Fold.,Johansson P, Bernstrom J, Gorman T, Oster L, Backstrom S, Schweikart F, Xu B, Xue Y, Schiavone LH Structure. 2013 Jan 15. pii: S0969-2126(12)00464-9. doi:, 10.1016/j.str.2012.12.009. PMID:23333428[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Johansson P, Bernstrom J, Gorman T, Oster L, Backstrom S, Schweikart F, Xu B, Xue Y, Schiavone LH. FAM3B PANDER and FAM3C ILEI Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-like Fold. Structure. 2013 Jan 15. pii: S0969-2126(12)00464-9. doi:, 10.1016/j.str.2012.12.009. PMID:23333428 doi:http://dx.doi.org/10.1016/j.str.2012.12.009
- ↑ Johansson P, Bernstrom J, Gorman T, Oster L, Backstrom S, Schweikart F, Xu B, Xue Y, Schiavone LH. FAM3B PANDER and FAM3C ILEI Represent a Distinct Class of Signaling Molecules with a Non-Cytokine-like Fold. Structure. 2013 Jan 15. pii: S0969-2126(12)00464-9. doi:, 10.1016/j.str.2012.12.009. PMID:23333428 doi:http://dx.doi.org/10.1016/j.str.2012.12.009
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