Eukaryotic initiation factor 3D structures

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**[[2if1]], [[1d7q]] – hEIF1 – human – NMR<BR />
**[[2if1]], [[1d7q]] – hEIF1 – human – NMR<BR />
**[[3zjy]] – hEIF1A + importin 13 + RanGTP<br />
**[[3zjy]] – hEIF1A + importin 13 + RanGTP<br />
 +
**[[6ybw]] – hEIF1A in 48S ribosome – Cryo EM<br />
**[[4kzx]], [[4kzy]], [[4kzz]] – rEIF1A in 40S ribosome – rabbit – cryo EM<br />
**[[4kzx]], [[4kzy]], [[4kzz]] – rEIF1A in 40S ribosome – rabbit – cryo EM<br />
**[[6yal]], [[6yan]] – rEIF1A+rEIF2A+EIF2C in 48S ribosome – Cryo EM<br />
**[[6yal]], [[6yan]] – rEIF1A+rEIF2A+EIF2C in 48S ribosome – Cryo EM<br />
Line 15: Line 16:
*EIF2
*EIF2
-
**[[1kl9]], [[1q8k]], [[5oa9]] – hEIF2A subunit 1<BR />
+
**[[1kl9]], [[1q8k]] – hEIF2A subunit α<BR />
-
**[[1q8x]] – hEIF2A - NMR<BR />
+
**[[3ecs]] – hEIF2B subunit α<br />
-
**[[3ecs]] – hEIF2B<br />
+
**[[7d46]], [[7l70]] – hEIF2B subunits α,β,γ,δ,ε – Cryo EM <br />
-
**[[6ezo]] – hEIF2B + drug <br />
+
**[[6ezo]] – hEIF2B subunits α,β,γ,δ,ε + drug <br />
-
**[[6o9z]], [[6o85]], [[6o81]], [[6k72]], [[6k71]], [[6i7t]], [[6k71]], [[6k72]], [[6o81]], [[6o85]], [[6o9z]] – hEIF2B + hEIF2 – Cryo EM <br />
+
**[[6o9z]], [[6o85]], [[6o81]], [[6k72]], [[6k71]], [[6i7t]], [[6k71]], [[6k72]], [[6o81]], [[6o85]], [[6o9z]], [[7d43]], [[7d44]], [[7d45]] – hEIF2B subunits α,β,γ,δ,ε + hEIF2 subunits α,β,γ – Cryo EM <br />
 +
**[[7kmf]] – hEIF2B subunits α,β,γ,δ,ε + fructofuranose – Cryo EM <br />
 +
**[[7l7g]] – hEIF2B subunits α,β,γ,δ,ε + inhibitor – Cryo EM <br />
 +
**[[5oa9]] – hEIF2D <br />
**[[5w2f]] – hEIF2D C-terminal <br />
**[[5w2f]] – hEIF2D C-terminal <br />
**[[5oa3]] – hEIF2D in 40S ribosome – Cryo EM <br />
**[[5oa3]] – hEIF2D in 40S ribosome – Cryo EM <br />
Line 25: Line 29:
**[[3wj9]] - EIF2A – fission yeast<br />
**[[3wj9]] - EIF2A – fission yeast<br />
**[[2a19]], [[2a1a]] – yEIF2A (mutant) + interferon-induced protein kinase<BR />
**[[2a19]], [[2a1a]] – yEIF2A (mutant) + interferon-induced protein kinase<BR />
 +
**[[1paq]] – yEIF2B e subunit catalytic domain 524-712 <br />
**[[6i3m]], [[6qg0]], [[6qg1]], [[6qg2]], [[6qg3]], [[6qg5]], [[6qg6]] – yEIF2B + yEIF2 – Cryo EM <br />
**[[6i3m]], [[6qg0]], [[6qg1]], [[6qg2]], [[6qg3]], [[6qg5]], [[6qg6]] – yEIF2B + yEIF2 – Cryo EM <br />
**[[4zgq]], [[4zgn]] – yEIF2G residues 410-527 + CDC123<br />
**[[4zgq]], [[4zgn]] – yEIF2G residues 410-527 + CDC123<br />
**[[3wj9]] - fyEIF2A – fission yeast<br />
**[[3wj9]] - fyEIF2A – fission yeast<br />
**[[6jlz]], [[6jly]] - fyEIF2A + EIF2B<br />
**[[6jlz]], [[6jly]] - fyEIF2A + EIF2B<br />
 +
**[[6i5m]] – SsEIF2 subunit γ + GDP – ''Sulfolobus solfataricus''<br />
 +
**[[6h6k]], [[6r8s]], [[6r8t]] – SsEIF2 subunit γ (mutant) + GDP <br />
 +
**[[2a0u]] – EIF2B – ''Leihmania major'' <br />
*EIF2C or argonaute
*EIF2C or argonaute
Line 43: Line 51:
*EIF3
*EIF3
 +
**[[6ybd]], [[6ybs]], [[6zvj]] - hEIF3 in 40S ribosome – cryo EM<br />
**[[3j8b]], [[3j8c]] - hEIF3A + hEIF3C + hEIF3E + hEIF3F + hEIF3H + hEIF3K + hEIF3L + hEIF3M – cryo EM<br />
**[[3j8b]], [[3j8c]] - hEIF3A + hEIF3C + hEIF3E + hEIF3F + hEIF3H + hEIF3K + hEIF3L + hEIF3M – cryo EM<br />
-
**[[5a5t]] - rEIF3A + rEIF3C + rEIF3E + rEIF3F + rEIF3H + rEIF3K + rEIF3M – Cryo EM - rat<br />**[[4kxt]], [[4krf]], [[4kre]], [[1si2]], [[1si3]] – hEI2C1 + RNA<br />
+
**[[6ybt]] - hEIF3A + hEIF3B + hEIF3I – cryo EM<br />
 +
**[[6ybv]] - hEIF3A + hEIF3B + hEIF3C + mRNA + initiator Met tRNA – cryo EM<br />
 +
**[[5a5t]] - rEIF3A + rEIF3C + rEIF3E + rEIF3F + rEIF3H + rEIF3K + rEIF3M – Cryo EM - rat<br />
 +
**[[6zce]], [[6zu9]], [[7a1g]] - yEIF3 in 40S ribosome – cryo EM<br />
 +
**[[4kxt]], [[4krf]], [[4kre]], [[1si2]], [[1si3]] – hEI2C1 + RNA<br />
**[[4k51]], [[4u1d]] - yEIF3A PCI domain<br />
**[[4k51]], [[4u1d]] - yEIF3A PCI domain<br />
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
**[[4u1c]] - yEIF3A PCI + yEIF3C PCI<br />
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**[[2g9n]], [[3bor]] – hEIF4A DEAD domain<BR />
**[[2g9n]], [[3bor]] – hEIF4A DEAD domain<BR />
 +
**[[2hxy]] – hEIF4A-III<br />
**[[1fuk]] – yEIF4A CTD<BR />
**[[1fuk]] – yEIF4A CTD<BR />
**[[1fuu]] - yEIF4A mRNA helicase domain<BR />
**[[1fuu]] - yEIF4A mRNA helicase domain<BR />
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**[[3ex7]], [[2xb2]] – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA<br />
**[[3ex7]], [[2xb2]] – hEIF4A + MAGO homolog + RNA-binding protein 8A + CASC3 + RNA<br />
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<br />
**[[2zu6]], [[3eiq]] – hEIF4A + programmed cell death protein<br />
 +
**[[9bln]] – hEIF4A+EIF3+EIF1 + Pdcd4 in 40S ribosome – Cryo EM <br />
**[[4c9b]] - hEIF4A + CWC22<br />
**[[4c9b]] - hEIF4A + CWC22<br />
-
**[[5zbz]] - hEIF4A-I DEAD domain + sanguinarine<br />
+
**[[7ppz]], [[7pq0]] - hEIF4A-I + Burkholderia lethal factor<br />
 +
**[[8huj]] - hEIF4A-I + EIF4G + RNA – Cryo EM<br />
**[[5xln]] - hEIF4A-II + ThrRS<br />
**[[5xln]] - hEIF4A-II + ThrRS<br />
**[[6yvh]] - hEIF4A-III + CWC22 + CWC27<br />
**[[6yvh]] - hEIF4A-III + CWC22 + CWC27<br />
-
**[[5mqf]], [[6icz]] - hEIF4A in splicesome – Cryo EM<br />
+
**[[7znj]] - hEIF4A-III + MAGO + RNA-binding protein + RNA – Cryo EM<br />
 +
**[[5mqf]], [[5xjc]], [[5yzg]], [[6icz]], [[7w59]], [[7w5a]], [[7w5b]] - hEIF4A in splicesome – Cryo EM<br />
**[[5t46]] - hEIF4E + EIF4GI<br />
**[[5t46]] - hEIF4E + EIF4GI<br />
**[[5nvn]] - hEIF4E + EIF4E-binding protein<br />
**[[5nvn]] - hEIF4E + EIF4E-binding protein<br />
**[[5nvm]], [[5nvl]], [[5nvk]] - hEIF4E + GRB10-interacting GYF protein<br />
**[[5nvm]], [[5nvl]], [[5nvk]] - hEIF4E + GRB10-interacting GYF protein<br />
**[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br />
**[[5ehc]], [[5ei3]], [[5eir]] - hEIF4E + EIF4GI + inhibitor<br />
 +
**[[8oz0]] – hEIF4A, EIF4F in 48S ribosome – Cryo EM<br />
 +
**[[7ddx]] - mEIF4A-I + KANK1 - mouse<br />
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<br />
**[[2vso]], [[2vsx]] - yEIF4E + yEIF4F<br />
**[[6fc3]] - yEIF4E + p20<br />
**[[6fc3]] - yEIF4E + p20<br />
**[[6fc2]], [[6fc1]] - yEIF4E + EAP1<br />
**[[6fc2]], [[6fc1]] - yEIF4E + EAP1<br />
-
**[[4axg]] - DmEIF4E + protein CUP – Drosophila melanogaster<br />
+
**[[4axg]] - DmEIF4E + protein CUP – ''Drosophila melanogaster''<br />
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-binding protein <br />
**[[4ue8]], [[4uea]], [[4ueb]], [[4ued]], [[5abu]], [[5abv]] - DmEIF4E + 4E-binding protein <br />
**[[4ue9]] - DmEIF4E + 4E transporter <br />
**[[4ue9]] - DmEIF4E + 4E transporter <br />
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**[[5zc9]] - hEIF4A-I + RNA + ATP analog + drug<br />
**[[5zc9]] - hEIF4A-I + RNA + ATP analog + drug<br />
 +
**[[9dts]] – hEIF4A-I + AMPPNP + rocaglate + RNA<br />
 +
**[[9avr]] – hEIF4A-I + AMPPNP + silvestrol + RNA<br />
 +
**[[5zbz]] - hEIF4A-I DEAD domain + sanguinarine<br />
 +
**[[6icz]], [[6qdv]], [[7a5p]] - hEIF4A-III in spliceosome – Cryo EM<br />
**[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br />
**[[5ekv]] - hEIF4E + 4E-BP1 peptide + inhibitor<br />
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[2jgb]] - hEIF4E + nucleotide + 4E-BP1 peptide<br />
**[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br />
**[[4tpw]], [[4tqb]], [[4tqc]] - hEIF4E + nucleotide + inhibitor<br />
**[[4bea]], [[5zml]], [[5zk9]], [[5zk7]], [[5zk5]], [[5zjz]], [[5zjy]] - hEIF4E + stapled peptide<br />
**[[4bea]], [[5zml]], [[5zk9]], [[5zk7]], [[5zk5]], [[5zjz]], [[5zjy]] - hEIF4E + stapled peptide<br />
-
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide - mouse<br />
+
**[[1ej1]], [[1l8b]], [[4b6u]], [[4b6v]] - mEIF4E + nucleotide <br />
**[[6u06]], [[6u09]] - mEIF4E + inhibitor<br />
**[[6u06]], [[6u09]] - mEIF4E + inhibitor<br />
 +
**[[6xki]] - mEIF4E + RNA + pateamine<br />
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[1ipb]], [[1ipc]] - hEIF4E + nucleotide<br />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
**[[4dt6]], [[4dum]] – hEIF4E + inhibitor<BR />
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**[[1xtd]] - EIF5A – ''Leishmania mexicana''<br />
**[[1xtd]] - EIF5A – ''Leishmania mexicana''<br />
**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
**[[3hks]] – EIF5A – ''Arabidopsis thaliana''<br />
 +
**[[6knd]], [[6kne]] – EIF5 CTD – ''Candida albicans''<br />
**[[6q84]] – yEIF5A + importin Kap122 + GTPase RAN + GTP<br />
**[[6q84]] – yEIF5A + importin Kap122 + GTPase RAN + GTP<br />
**[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br />
**[[3wbi]], [[3wbj]], [[4n3s]] – yEIF5B<br />
Line 156: Line 181:
*EIF6
*EIF6
 +
**[[6lqm]], [[6lsr]], [[6lss]], [[6lu8]] – hEIF6 in pre-60S ribosome – cryo EM<br />
**[[1g62]] – yEIF6 <br />
**[[1g62]] – yEIF6 <br />
**[[2x7n]] – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24<br />
**[[2x7n]] – yEIF6S + sarcin-ricin loop + ribosomal protein L23 + ribosomal protein L24<br />

Current revision

3D structures of eukaryotic initiation factor

Updated on 03-June-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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