FKBP 3D structures

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: == 3D Structures of FKBP == Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *FKBP **1fkr, 1fks, 1fkt ...)
Current revision (09:26, 3 July 2025) (edit) (undo)
 
(3 intermediate revisions not shown.)
Line 10: Line 10:
**[[1bkf]] – hFKBP (mutant)+FK-506<br />
**[[1bkf]] – hFKBP (mutant)+FK-506<br />
**[[1fkf]] - hFKBP+FK-506<br />
**[[1fkf]] - hFKBP+FK-506<br />
 +
**[[7dki]] – FKBP - silk worm<br />
**[[1fks]], [[1fkr]], [[1fkt]] – EcFKBP – ''Escherichia coli''<br />
**[[1fks]], [[1fkr]], [[1fkt]] – EcFKBP – ''Escherichia coli''<br />
**[[1q6h]], [[1q6u]] – EcFKBP<br />
**[[1q6h]], [[1q6u]] – EcFKBP<br />
Line 15: Line 16:
**[[1ix5]] – FKBP – ''Methanothermococcus thermolithotrophicus'' – NMR<br />
**[[1ix5]] – FKBP – ''Methanothermococcus thermolithotrophicus'' – NMR<br />
-
*FKBP1
+
*FKBP1B
-
**[[4n19]] - hFKBP-1A (mutant)<br />
 
-
**[[3mdy]] – hFKBP-1A + BMPR1B<br />
 
-
**[[3h9r]], [[6i1s]] - hFKBP-1A+ activin receptor type I<br />
 
-
**[[1j4r]] – hFKBP-1+FKB-001<br />
 
-
**[[4dh0]] - hFKBP-1A+ rapamycin<br />
 
-
**[[6oqa]] - hFKBP-1A+ CEP250<br />
 
**[[4iq2]], [[4iqc]] - hFKBP-1B (mutant)<br />
**[[4iq2]], [[4iqc]] - hFKBP-1B (mutant)<br />
**[[4c02]] - hFKBP-1B+ activin receptor type I<br />
**[[4c02]] - hFKBP-1B+ activin receptor type I<br />
 +
**[[5tap]], [[6jgz]], [[6jh6]], [[6jhn]], [[6ji0]], [[6jrr]], [[6pv6]], [[6w1n]], [[6wot]], [[6wou]], [[6wov]], [[6x34]], [[7cf9]], [[7jmf]], [[7jmg]], [[7jmh]], [[7jmi]], [[7jmj]] - hFKBP-1B + ryanodine receptor type I – Cryo EM<br />
 +
**[[6ji8]], [[6jii]], [[6jiu]], [[6jiy]], [[6jrs]], [[6m2w]], [[6x32]], [[6x33]], [[6x35]], [[6x36]] - hFKBP-1B + ryanodine receptor type I + calmodulin 1 – Cryo EM<br />
 +
**[[8z28]], [[8z38]] - FKBP-1B – ''Pyricularia oryzae''<br />
*FKBP3
*FKBP3
**[[3kz7]] – hFKBP FK506-binding domain + immunosuppressant - human
**[[3kz7]] – hFKBP FK506-binding domain + immunosuppressant - human
- 
-
*FKBP4; Domains – FK1 or FK506-binding 1-148
 
- 
-
**[[1q1c]], [[4lav]], [[4law]] – hFKBP <br />
 
-
**[[1n1a]] – hFKBP N terminal<br />
 
-
**[[1p5q]] - hFKBP C terminal<br />
 
-
**[[6rcy]] – hFKBP FK1 domain<br />
 
-
**[[1qz2]] – hFKBP + Hsp90 peptide<br />
 
-
**[[4drj]] – hFKBP FK1 + serine/threonine-protein kinase FRB domain + Immunospressant<br />
 
- 
-
*FKBP5
 
- 
-
**[[3o5d]], [[3o5e]], [[3o5f]], [[5omp]], [[5obk]] – hFKBP<br />
 
-
**[[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK1 domain<br />
 
-
**[[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3o5q]] - hFKBP FK1 domain (mutant)<br />
 
-
**[[6tx4]] – hFKBP FK1 domain + pyridone<br />
 
-
**[[6tx6]] – hFKBP FK1 domain + nicotinamide<br />
 
-
**[[6tx5]], [[6tx8]] – hFKBP FK1 domain (mutant) + imidazole derivative<br />
 
-
**[[6tx7]] – hFKBP FK1 domain (mutant) + piperidone derivative<br />
 
-
**[[6tx9]] – hFKBP FK1 domain (mutant) + hydantoin derivative<br />
 
-
**[[6saf]], [[6txx]] – hFKBP FK1 domain (mutant) + ligand<br />
 
-
**[[4lax]] – hFKBP + FK506<br />
 
-
**[[4lay]] – hFKBP + I63<br />
 
-
**[[3o5r]] - hFKBP FK1 domain (mutant) + immunosuppressant<br />
 
-
**[[4drq]] – hFKBP + pipecolate sulfonamide<br />
 
-
**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br />
 
-
**[[5njx]] – hFKBP + Hsp90 peptide<br />
 
*FKBP8
*FKBP8
-
**[[2f2d]], [[3ey6]], [[2awg]] - hFKBP FK506-binding domain<br />
+
**[[2awg]], [[2f2d]], [[3ey6]] - hFKBP FK506-binding domain<br />
**[[2d9f]] – hFKBP – NMR<br />
**[[2d9f]] – hFKBP – NMR<br />
**[[2mf9]] – hFKBP N terminal 58-206 – NMR<br />
**[[2mf9]] – hFKBP N terminal 58-206 – NMR<br />
-
*FKBP12
+
*FKBP12 or PPIase FKBP1A
-
**[[1fkk]], [[2ppp]], [[2ppn]], [[2dg3]], [[1d6o]] – hFKBP<br />
+
**[[1d6o]], [[1fkk]], [[2dg3]], [[2ppn]], [[2ppp]], [[8x6p]] – hFKBP<br />
-
**[[1eym]], [[2ppo]], [[4ipx]] – hFKBP (mutant) <br />
+
**[[1eym]], [[2ppo]], [[4ipx]], [[4n19]] – hFKBP (mutant) <br />
**[[2gaq]], [[2pnu]] – hFKBP - NMR<br />
**[[2gaq]], [[2pnu]] – hFKBP - NMR<br />
**[[3uqi]] – ymFKBP – yellowfever mosquito<br />
**[[3uqi]] – ymFKBP – yellowfever mosquito<br />
Line 75: Line 46:
**[[5hwb]] – NfFKBP – ''Neosartorya fumigata''<br />
**[[5hwb]] – NfFKBP – ''Neosartorya fumigata''<br />
**[[5j6e]] – NfFKBP (mutant) <br />
**[[5j6e]] – NfFKBP (mutant) <br />
 +
**[[6vsi]] – FKBP – ''Candida auris'' <br />
*FKBP12 complex
*FKBP12 complex
-
**[[1fkd]], [[1fkj]], [[2fke]], [[1qpf]], [[1qpl]] – hFKBP + immunosuppressant<br />
+
**[[1fkd]], [[1fkj]], [[1qpf]], [[1qpl]], [[2fke]] – hFKBP + immunosuppressant<br />
-
**[[1j4h]], [[1j4i]] – hFKBP + inhibitor<br />
+
**[[1j4h]], [[1j4i]], [[9lyg]] – hFKBP + inhibitor<br />
 +
**[[8chi]], [[8chj]], [[8chk]], [[8chl]], [[8chm]], [[8pdf]] – hFKBP (mutant) + inhibitor<br />
 +
**[[9dcw]] – hFKBP + macrocycle molecular glue<br />
**[[1b6c]] – hFKBP + TGF-B superfamily receptor I<br />
**[[1b6c]] – hFKBP + TGF-B superfamily receptor I<br />
**[[3fap]] – hFKBP + FKBP12-rapamycin associated protein<br />
**[[3fap]] – hFKBP + FKBP12-rapamycin associated protein<br />
**[[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant<br />
**[[4fap]] - hFKBP + FKBP12-rapamycin associated protein + immunosuppressant<br />
-
**[[2dg4]], [[1fkb]], [[1c9h]], [[4dh0]] - hFKBP+rapamycin<br />
+
**[[1c9h]], [[1fkb]], [[2dg4]], [[4dh0]] - hFKBP+rapamycin<br />
-
**[[2dg9]] - hFKBP (mutant)+rapamycin<br />
+
**[[2dg9]], [[7u8d]] - hFKBP (mutant)+rapamycin<br />
-
**[[2fap]], [[1nsg]], [[1fap]] - hFKBP+rapamycin+FRB<br />
+
**[[1fap]], [[1nsg]], [[2fap]] - hFKBP+rapamycin+FRB<br />
**[[1f40]] – hFKBP +GPI-1046<br />
**[[1f40]] – hFKBP +GPI-1046<br />
**[[1a7x]] – hFKBP +FK-1012<br />
**[[1a7x]] – hFKBP +FK-1012<br />
**[[1d7h]], [[1d7i]], [[1d7j]], [[1fkg]], [[1fkh]], [[1fki]] – hFKBP +ligand<br />
**[[1d7h]], [[1d7i]], [[1d7j]], [[1fkg]], [[1fkh]], [[1fki]] – hFKBP +ligand<br />
 +
**[[6vcu]], [[6yf0]], [[6yf1]], [[6yf2]], [[6yf3]] – hFKBP + drug<br />
 +
**[[8er6]], [[8er7]] – hFKBP + serine/threonine protein kinase 224-317 + inhibitor<br />
 +
**[[6m4u]], [[8ppz]] – hFKBP + serine/threonine protein kinase MTOR peptide <br />
**[[2rse]] – hFKBP + serine/threonine protein kinase MTOR peptide + rapamycin - NMR<br />
**[[2rse]] – hFKBP + serine/threonine protein kinase MTOR peptide + rapamycin - NMR<br />
 +
**[[8era]] – hFKBP + serine/threonine protein kinase MTOR + LST8 – Cryo EM<br />
 +
**[[6m4v]], [[6m4w]] – hFKBP + MBP + rapamycin<br />
 +
**[[3h9r]], [[6i1s]], [[8pod]] – hFKBP + activin receptor type I<br />
 +
**[[3mdy]] – hFKBP+ BMPR1B<br />
 +
**[[1j4r]] – hFKBP + FKB-001<br />
 +
**[[6oqa]] – hFKBP + CEP250<br />
 +
**[[7m6a]], [[7m6l]], [[7vml]], [[7vmm]], [[7vmn]], [[7vmo]], [[7vmp]], [[7vmq]], [[7vmr]], [[7vms]], [[7u0s]], [[7u8d]], [[7u9q]], [[7u9r]], [[7u9t]], [[7u9x]], [[7u9z]], [[7ua1]], [[7ua3]], [[7ua4]], [[7ua5]], [[7ua9]] - hFKBP + ryanodine receptor type 2 – Cryo EM<br />
**[[1tco]] - bFKBP + Ser/Thr phosphatase B2 + immunosuppressant - bovine<br />
**[[1tco]] - bFKBP + Ser/Thr phosphatase B2 + immunosuppressant - bovine<br />
**[[1fkl]] – bFKBP +rapamycin <br />
**[[1fkl]] – bFKBP +rapamycin <br />
Line 96: Line 80:
**[[5hw8]] – CaFKBP (mutant) + FK506<br />
**[[5hw8]] – CaFKBP (mutant) + FK506<br />
**[[6tz6]] – CaFKBP + FK506 + calcineurin B + serine/threonine protein phosphatase<br />
**[[6tz6]] – CaFKBP + FK506 + calcineurin B + serine/threonine protein phosphatase<br />
 +
**[[6vcv]] - NfFKBP + FK506 analog <br />
**[[5hwc]] – NfFKBP (mutant) + FK506<br />
**[[5hwc]] – NfFKBP (mutant) + FK506<br />
**[[6tz7]] – NfFKBP + FK506 + calcineurin B + serine/threonine protein phosphatase<br />
**[[6tz7]] – NfFKBP + FK506 + calcineurin B + serine/threonine protein phosphatase<br />
**[[6tz8]] – FKBP + FK506 + calcineurin B + serine/threonine protein phosphatase – ''Cryptococcus neoformans''<br />
**[[6tz8]] – FKBP + FK506 + calcineurin B + serine/threonine protein phosphatase – ''Cryptococcus neoformans''<br />
 +
**[[6vct]], [[6vrx]] – FKBP + FK506 analog – ''Mucor circinelloides''<br />
*FKBP12.6
*FKBP12.6
**[[5hkg]] – hFKBP <br />
**[[5hkg]] – hFKBP <br />
 +
**[[7t64]], [[7t65]], [[7tzc]], [[8dty]], [[8dtz]], [[8dvv]], [[9cgp]], [[9cgq]] - rFKBP + ryanodine receptor type 1 – Cryo EM<br />
*FKBP13
*FKBP13
Line 108: Line 95:
**[[2pbc]] – hFKBP <br />
**[[2pbc]] – hFKBP <br />
**[[4nnr]] – hFKBP + FK506<br />
**[[4nnr]] – hFKBP + FK506<br />
-
**[[1y0o]], [[1u79]] – AtFKBP - ''Arabidopsis thaliana''
+
**[[1u79]], [[1y0o]] – AtFKBP - ''Arabidopsis thaliana''
*FKBP14
*FKBP14
Line 153: Line 140:
**[[2if4]] – AtFKBP <br />
**[[2if4]] – AtFKBP <br />
-
*FKBP51
+
*FKBP51 or PPIase FKBP5; Domains – FK1 1-140; FK2 141-260
-
**[[1kt0]], [[1kt1]] – hFKBP<br />
+
**[[1kt1]], [[5omp]] – hFKBP<br />
-
**[[4r0x]] – hFKBP FK1 domain (mutant) <br />
+
**[[1kt0]] – hFKBP (mutant)<br />
-
**[[4drq]] – hFKBP FK1 domain + pipecolate sulfonamide<br />
+
**[[5njx]] – hFKBP + Hsp90 peptide<br />
-
**[[4jfi]], [[4jfj]], [[4jfk]], [[4jfl]], [[4jfm]], [[4tw6]], [[4tw7]], [[4tx0]], [[4w9o]], [[4w9p]], [[4w9q]], [[5dit]], [[5diu]], [[5div]] – hFKBP FK1 domain (mutant) + inhibitor<br />
+
**[[7l7i]] – hFKBP + Hsp90 + P23 – Cryo EM<br />
 +
**[[3o5d]] – hFKBP FK1+FK2 domains <br />
 +
**[[3o5e]], [[3o5f]], [[3o5g]], [[3o5i]], [[3o5j]], [[3o5k]] - hFKBP FK1 domain<br />
 +
**[[3o5l]], [[3o5m]], [[3o5o]], [[3o5p]], [[3o5q]], [[4r0x]] - hFKBP FK1 domain (mutant)<br />
 +
**[[4lax]] – hFKBP FK1+FK2 domains + FK506<br />
 +
**[[4lay]] – hFKBP FK1+FK2 domains + I63<br />
 +
**[[3o5r]] - hFKBP FK1 domain (mutant) + immunosuppressant<br />
 +
**[[4drq]], [[5obk]], [[7a6w]], [[7a6x]], [[7aot]], [[7aou]], [[7apq]], [[7aps]], [[7apt]], [[7apw]], [[7awf]], [[7awx]], [[7b9y]], [[7b9z]], [[7ba0]], [[8chn]], [[8chp]], [[8chq]], [[8chr]], [[9eu6]], [[9eu7]], [[9eu8]] [[9eu9]], [[9eua]], [[9eub]], [[9euc]], [[9eud]], [[9eue]], [[9ey3]], [[9ey4]] – hFKBP FK1 domain + inhibitor<br />
 +
**[[4jfi]], [[4jfj]], [[4jfk]], [[4jfl]], [[4jfm]], [[4tw6]], [[4tw7]], [[4tx0]], [[4w9o]], [[4w9p]], [[4w9q]], [[5dit]], [[5diu]], [[5div]], [[7r0l]], [[8ba6]], [[8baj]], [[8cca]], [[8ccb]], [[8ccd]], [[8cce]], [[8ccf]], [[8ccg]], [[8cch]], [[8pj8]], [[8pja]], [[8r5k]] – hFKBP FK1 domain (mutant) + inhibitor<br />
 +
**[[9gpk]], [[9gpl]], [[9gpm]], [[9gpn]], [[9gpo]], [[9gpp]], [[9gpq]], [[9gpr]], [[9gps]], [[9gpt]], [[9gpu]], [[9gpv]], [[9gpw]], [[9gpx]], [[9gpy]], [[9gpz]], [[9gq2]], [[9gq3]], [[9gq4]], [[9gq5]], [[9gq6]], [[9gq7]], [[9gq8]], [[9gq9]], [[9gqa]], [[9gqb]], [[9gqc]], [[9gqd]], [[9gqe]], [[9gqf]], [[9gqg]], [[9gqh]], [[9gqi]], [[9gqj]], [[9gqk]] – hFKBP FK1 domain (mutant) + macrocyclic inhibitor<br />
 +
**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br />
 +
**[[7ett]], [[7etu]], [[7etv]] – hFKBP FK1 domain (mutant) + peptide inhibitor<br />
**[[5bxj]] – hFKBP FK1 domain (mutant) + nitrophenol<br />
**[[5bxj]] – hFKBP FK1 domain (mutant) + nitrophenol<br />
**[[4tw8]] – hFKBP FK1+FK2 domains (mutant) + inhibitor<br />
**[[4tw8]] – hFKBP FK1+FK2 domains (mutant) + inhibitor<br />
**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br />
**[[4drk]], [[4drm]], [[4drn]], [[4dro]], [[4drp]] – hFKBP FK1 domain + FK506 analog<br />
 +
**[[8era]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR + TORC + raptor – Cryo EM <br />
**[[4drh]], [[4dri]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin <br />
**[[4drh]], [[4dri]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin <br />
 +
**[[6tx4]] – hFKBP FK1 domain + pyridone<br />
 +
**[[6tx6]] – hFKBP FK1 domain + nicotinamide<br />
 +
**[[6tx5]], [[6tx8]] – hFKBP FK1 domain (mutant) + imidazole derivative<br />
 +
**[[6tx7]] – hFKBP FK1 domain (mutant) + piperidone derivative<br />
 +
**[[6tx9]] – hFKBP FK1 domain (mutant) + hydantoin derivative<br />
 +
**[[6saf]], [[6txx]] – hFKBP FK1 domain (mutant) + ligand<br />
 +
**[[8pc2]] – hFKBP FK1 domain (mutant) + seldeg51 + pvhl + elongin B + elongin C<br />
 +
**[[8ffw]] – hFKBP + Hsp90 peptide + glucocorticoid receptor – Cryo EM
-
*FKBP52
+
*FKBP52 or PPIase FKBP4
 +
**[[8ffv]] – hFKBP + Hsp90 peptide + glucocorticoid receptor – Cryo EM
 +
**[[4lav]], [[4law]] – hFKBP FK1+FK2 domains 16-260<br />
 +
**[[1n1a]], [[1q1c]] – hFKBP N terminal 1-140<br />
 +
**[[1p5q]] - hFKBP C terminal 144-458<br />
**[[4drj]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin <br />
**[[4drj]] – hFKBP FK1 domain + serine/threonine protein kinase MTOR peptide + rapamycin <br />
 +
**[[6rcy]] – hFKBP FK1 domain + ligand<br />
 +
**[[1qz2]] – hFKBP C-terminal + Hsp90 peptide<br />
 +
 +
*FKBP53
 +
 +
**[[8zaj]] – AtFKBP nucleoplasmin domain 1-100 – Cryo EM
*FKBP59
*FKBP59
Line 176: Line 193:
*FKBP73
*FKBP73
-
**[[3jym]], [[3jxv]] - FKBP - wheat
+
**[[3jxv]], [[3jym]] - FKBP - wheat
*SlyD
*SlyD
Line 182: Line 199:
See [[Peptidyl-prolyl cis-trans isomerase]]
See [[Peptidyl-prolyl cis-trans isomerase]]
}}
}}
 +
[[Category: Topic Page]]

Current revision

3D Structures of FKBP

Updated on 03-July-2025

See Peptidyl-prolyl cis-trans isomerase

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

Retrieved from "http://52.214.119.220/wiki/index.php/FKBP_3D_structures"
Personal tools