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2zx1

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Rhamnose-binding lectin CSL3

Structural highlights

2zx1 is a 2 chain structure with sequence from Oncorhynchus keta. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.9Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CSL3_ONCKE

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of the L-rhamnose-binding lectin CSL3 was determined to 1.8 A resolution. This protein is a component of the germline-encoded pattern recognition proteins in innate immunity. CSL3 is a homodimer of two 20 kDa subunits with a dumbbell-like shape overall, in which the N- and C-terminal domains of different subunits form lobe structures connected with flexible linker peptides. The complex structures of the protein with specific carbohydrates demonstrated the importance of the most variable loop region among homologues for the specificity toward oligosaccharides. CSL3 and Shiga-like toxin both use Gb(3) as a cellular receptor to evoke apoptosis. They have very different overall architecture but share the separation distance between carbohydrate-binding sites. An inspection of the structure database suggested that the pseudo-tetrameric structure of CSL3 was unique among the known lectins. This architecture implies this protein might provide a unique tool for further investigations into the relationships between architecture and function of pattern recognition proteins.

Structure of rhamnose-binding lectin CSL3: unique pseudo-tetrameric architecture of a pattern recognition protein.,Shirai T, Watanabe Y, Lee MS, Ogawa T, Muramoto K J Mol Biol. 2009 Aug 14;391(2):390-403. Epub 2009 Jun 12. PMID:19524596^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Shirai T, Watanabe Y, Lee MS, Ogawa T, Muramoto K. Structure of rhamnose-binding lectin CSL3: unique pseudo-tetrameric architecture of a pattern recognition protein. J Mol Biol. 2009 Aug 14;391(2):390-403. Epub 2009 Jun 12. PMID:19524596 doi:10.1016/j.jmb.2009.06.027

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2zx1"

@@ Line 3: / Line 3: @@
 <StructureSection load='2zx1' size='340' side='right'caption='[[2zx1]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2zx1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Oncorhynchus_keta Oncorhynchus keta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZX1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2ZX1 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2zx1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Oncorhynchus_keta Oncorhynchus keta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ZX1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ZX1 FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zx0|2zx0]], [[2zx2|2zx2]], [[2zx3|2zx3]], [[2zx4|2zx4]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zx1 OCA], [http://pdbe.org/2zx1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2zx1 RCSB], [http://www.ebi.ac.uk/pdbsum/2zx1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2zx1 ProSAT]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2zx1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2zx1 OCA], [https://pdbe.org/2zx1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2zx1 RCSB], [https://www.ebi.ac.uk/pdbsum/2zx1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2zx1 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/CSL3_ONCKE CSL3_ONCKE]
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 33: / Line 35: @@
 [[Category: Large Structures]]
 [[Category: Oncorhynchus keta]]
-[[Category: Lee, M]]
+[[Category: Lee M]]
-[[Category: Muramoto, K]]
+[[Category: Muramoto K]]
-[[Category: Ogawa, T]]
+[[Category: Ogawa T]]
-[[Category: Shirai, T]]
+[[Category: Shirai T]]
-[[Category: Watababe, Y]]
+[[Category: Watababe Y]]
-[[Category: Immune system]]
-[[Category: Innate immunity]]
-[[Category: Lectin]]
-[[Category: Rhamnose]]
-[[Category: Sugar binding protein]]

2zx1

From Proteopedia

Current revision

Rhamnose-binding lectin CSL3

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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