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3a28

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Current revision (14:08, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3a28' size='340' side='right'caption='[[3a28]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3a28' size='340' side='right'caption='[[3a28]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3a28]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"micrococcus_glutamicus"_kinoshita_et_al._1958 "micrococcus glutamicus" kinoshita et al. 1958]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A28 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3A28 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3a28]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_glutamicum Corynebacterium glutamicum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3A28 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3A28 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1geg|1geg]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3a28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a28 OCA], [http://pdbe.org/3a28 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3a28 RCSB], [http://www.ebi.ac.uk/pdbsum/3a28 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3a28 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3a28 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3a28 OCA], [https://pdbe.org/3a28 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3a28 RCSB], [https://www.ebi.ac.uk/pdbsum/3a28 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3a28 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BUDC_CORGT BUDC_CORGT]] Catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol (L-BD) in the presence of NADH. To a lesser extent, can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD, D-BD, 2-butanol, 1,2-propanediol, ethanol, acetol, 1,2-butanediol, 1,3-butanediol, n-butanol, and n-propanol. Cannot reduce (R)-acetoin, acetol, dihydroxyacetone and 2,4-pentanedione.[REFERENCE:1]<ref>PMID:11577733</ref>
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[https://www.uniprot.org/uniprot/BUDC_CORGT BUDC_CORGT] Catalyzes the reversible reduction of (S)-acetoin to (S,S)-butane-2,3-diol (L-BD) in the presence of NADH. To a lesser extent, can also catalyze the irreversible reduction of diacetyl to (S)-acetoin. Cannot oxidize meso-BD, D-BD, 2-butanol, 1,2-propanediol, ethanol, acetol, 1,2-butanediol, 1,3-butanediol, n-butanol, and n-propanol. Cannot reduce (R)-acetoin, acetol, dihydroxyacetone and 2,4-pentanedione.[REFERENCE:1]<ref>PMID:11577733</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Micrococcus glutamicus kinoshita et al. 1958]]
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[[Category: Corynebacterium glutamicum]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Kurisu, G]]
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[[Category: Kurisu G]]
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[[Category: Kusunoki, M]]
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[[Category: Kusunoki M]]
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[[Category: Otagiri, M]]
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[[Category: Otagiri M]]
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[[Category: Ui, S]]
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[[Category: Ui S]]
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[[Category: Chiral substrate recognition]]
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[[Category: Oxidoreductase]]
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Current revision

Crystal structure of L-2,3-butanediol dehydrogenase

PDB ID 3a28

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