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| | <StructureSection load='3aqy' size='340' side='right'caption='[[3aqy]], [[Resolution|resolution]] 1.58Å' scene=''> | | <StructureSection load='3aqy' size='340' side='right'caption='[[3aqy]], [[Resolution|resolution]] 1.58Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[3aqy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Indian_meal_moth Indian meal moth]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQY OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3AQY FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[3aqy]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plodia_interpunctella Plodia interpunctella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AQY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AQY FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ie4|3ie4]], [[2rqe|2rqe]], [[2kha|2kha]], [[3aqx|3aqx]], [[3aqz|3aqz]]</td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.58Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3aqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aqy OCA], [http://pdbe.org/3aqy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3aqy RCSB], [http://www.ebi.ac.uk/pdbsum/3aqy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3aqy ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3aqy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3aqy OCA], [https://pdbe.org/3aqy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3aqy RCSB], [https://www.ebi.ac.uk/pdbsum/3aqy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3aqy ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/BGBP_PLOIN BGBP_PLOIN] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Indian meal moth]] | |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Adachi, Y]] | + | [[Category: Plodia interpunctella]] |
| - | [[Category: Ikeda, A]] | + | [[Category: Adachi Y]] |
| - | [[Category: Kanagawa, M]] | + | [[Category: Ikeda A]] |
| - | [[Category: Ohno, N]] | + | [[Category: Kanagawa M]] |
| - | [[Category: Satoh, T]] | + | [[Category: Ohno N]] |
| - | [[Category: Yamaguchi, Y]] | + | [[Category: Satoh T]] |
| - | [[Category: 3-glucan]]
| + | [[Category: Yamaguchi Y]] |
| - | [[Category: Beta-1]]
| + | |
| - | [[Category: Beta-sandwich]]
| + | |
| - | [[Category: Immune receptor]]
| + | |
| - | [[Category: Sugar binding protein]]
| + | |
| Structural highlights
Function
BGBP_PLOIN
Publication Abstract from PubMed
Innate ability to detect pathogens is achieved by pattern recognition receptors (PRRs) which recognise non-self components such as beta1,3-glucan. beta1,3-Glucans form a triple-helical structure stabilised by inter-chain hydrogen bonds. beta1,3-Glucan recognition protein (betaGRP)/gram-negative bacteria-binding protein 3 (GNBP3), one of PPRs, binds to long, structured beta1,3-glucan to initiate innate immune response. However, binding details and how specificity is achieved in such receptors remain important outstanding issues. We solved the crystal structures of the N-terminal beta1,3-glucan recognition domain of betaGRP/GNBP3 (betaGRP-N) in complex with the beta1,3-linked glucose hexamer, laminarihexaose. In the crystals, three structured laminarihexaoses simultaneously interact through six glucose residues (two from each chain) with one betaGRP-N. The spatial arrangement of the laminarihexaoses bound to betaGRP-N is almost identical to that of a beta1,3-glucan triplex. Therefore, our crystallographic structures together with site-directed mutagenesis data provide a structural basis for the unique recognition by such receptors of the triple-helix structure of beta1,3-glucan.
Structural insights into recognition of triple-helical {beta}-glucan by insect fungal receptor.,Kanagawa M, Satoh T, Ikeda A, Adachi Y, Ohno N, Yamaguchi Y J Biol Chem. 2011 Jun 22. PMID:21697086[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Kanagawa M, Satoh T, Ikeda A, Adachi Y, Ohno N, Yamaguchi Y. Structural insights into recognition of triple-helical {beta}-glucan by insect fungal receptor. J Biol Chem. 2011 Jun 22. PMID:21697086 doi:10.1074/jbc.M111.256701
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