1cd1

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[[Image:1cd1.gif|left|200px]]
 
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==CD1(MOUSE) ANTIGEN PRESENTING MOLECULE==
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The line below this paragraph, containing "STRUCTURE_1cd1", creates the "Structure Box" on the page.
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<StructureSection load='1cd1' size='340' side='right'caption='[[1cd1]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cd1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CD1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CD1 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cd1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cd1 OCA], [https://pdbe.org/1cd1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cd1 RCSB], [https://www.ebi.ac.uk/pdbsum/1cd1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cd1 ProSAT]</span></td></tr>
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{{STRUCTURE_1cd1| PDB=1cd1 | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cd/1cd1_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cd1 ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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CD1 represents a third lineage of antigen-presenting molecules that are distantly related to major histocompatibility complex (MHC) molecules in the immune system. The crystal structure of mouse CD1d1, corresponding to human CD1d, at 2.8 resolution shows that CD1 adopts an MHC fold that is more closely related to that of MHC class I than to that of MHC class II. The binding groove, although significantly narrower, is substantially larger because of increased depth and it has only two major pockets that are almost completely hydrophobic. The extreme hydrophobicity and shape of the binding site are consistent with observations that human CD1b and CD1c can present mycobacterial cell wall antigens, such as mycolic acid and lipoarabinomannans. However, mouse CD1d1 can present very hydrophobic peptides, but must do so in a very different way from MHC class Ia and class II molecules.
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'''CD1(MOUSE) ANTIGEN PRESENTING MOLECULE'''
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Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove.,Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, Wilson IA Science. 1997 Jul 18;277(5324):339-45. PMID:9219685<ref>PMID:9219685</ref>
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==Overview==
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CD1 represents a third lineage of antigen-presenting molecules that are distantly related to major histocompatibility complex (MHC) molecules in the immune system. The crystal structure of mouse CD1d1, corresponding to human CD1d, at 2.8 resolution shows that CD1 adopts an MHC fold that is more closely related to that of MHC class I than to that of MHC class II. The binding groove, although significantly narrower, is substantially larger because of increased depth and it has only two major pockets that are almost completely hydrophobic. The extreme hydrophobicity and shape of the binding site are consistent with observations that human CD1b and CD1c can present mycobacterial cell wall antigens, such as mycolic acid and lipoarabinomannans. However, mouse CD1d1 can present very hydrophobic peptides, but must do so in a very different way from MHC class Ia and class II molecules.
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==About this Structure==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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1CD1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CD1 OCA].
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</div>
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<div class="pdbe-citations 1cd1" style="background-color:#fffaf0;"></div>
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==Reference==
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==See Also==
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Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove., Zeng Z, Castano AR, Segelke BW, Stura EA, Peterson PA, Wilson IA, Science. 1997 Jul 18;277(5324):339-45. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9219685 9219685]
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[CD1|CD1]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Protein complex]]
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[[Category: Segelke BW]]
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[[Category: Segelke, B W.]]
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[[Category: Wilson IA]]
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[[Category: Wilson, I A.]]
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[[Category: Zeng ZH]]
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[[Category: Zeng, Z H.]]
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[[Category: Cd1]]
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[[Category: Glycoprotein]]
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[[Category: Immunoglobulin fold]]
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[[Category: Immunology]]
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[[Category: Mhc]]
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[[Category: Signal]]
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[[Category: T-cell]]
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[[Category: Tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:35:48 2008''
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Current revision

CD1(MOUSE) ANTIGEN PRESENTING MOLECULE

PDB ID 1cd1

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