7jl5

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'''Unreleased structure'''
 
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The entry 7jl5 is ON HOLD until Paper Publication
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==Crystal structure of human NEIL3 tandem zinc finger GRF domains==
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<StructureSection load='7jl5' size='340' side='right'caption='[[7jl5]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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Authors: Rodriguez, A.A., Wojtaszek, J.L., Williams, R.S., Eichman, B.F.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7jl5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JL5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JL5 FirstGlance]. <br>
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Description: Crystal structure of human NEIL3 tandem zinc finger GRF domains
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Rodriguez, A.A]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jl5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jl5 OCA], [https://pdbe.org/7jl5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jl5 RCSB], [https://www.ebi.ac.uk/pdbsum/7jl5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jl5 ProSAT]</span></td></tr>
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[[Category: Wojtaszek, J.L]]
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</table>
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[[Category: Eichman, B.F]]
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== Function ==
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[[Category: Williams, R.S]]
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[https://www.uniprot.org/uniprot/NEIL3_HUMAN NEIL3_HUMAN] DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.<ref>PMID:12433996</ref> <ref>PMID:19170771</ref> <ref>PMID:22569481</ref> <ref>PMID:23755964</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Eichman BF]]
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[[Category: Rodriguez AA]]
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[[Category: Williams RS]]
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[[Category: Wojtaszek JL]]

Current revision

Crystal structure of human NEIL3 tandem zinc finger GRF domains

PDB ID 7jl5

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