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6y1z

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Current revision (07:00, 14 September 2022) (edit) (undo)
 
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<SX load='6y1z' size='340' side='right' viewer='molstar' caption='[[6y1z]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
<SX load='6y1z' size='340' side='right' viewer='molstar' caption='[[6y1z]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6y1z]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y1Z OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6Y1Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6y1z]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Y1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Y1Z FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=O7B:(3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one'>O7B</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=HIS:HISTIDINE'>HIS</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=O7B:(3~{a}~{S})-2-[(3~{S})-1-azabicyclo[2.2.2]octan-3-yl]-3~{a},4,5,6-tetrahydro-3~{H}-benzo[de]isoquinolin-1-one'>O7B</scene>, <scene name='pdbligand=TRP:TRYPTOPHAN'>TRP</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Htr3a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6y1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y1z OCA], [https://pdbe.org/6y1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6y1z RCSB], [https://www.ebi.ac.uk/pdbsum/6y1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6y1z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6y1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6y1z OCA], [http://pdbe.org/6y1z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6y1z RCSB], [http://www.ebi.ac.uk/pdbsum/6y1z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6y1z ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/5HT3A_MOUSE 5HT3A_MOUSE]] This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6y1z" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6y1z" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[5-hydroxytryptamine receptor 3D structures|5-hydroxytryptamine receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</SX>
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Nury, H]]
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[[Category: Nury H]]
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[[Category: Perot, J]]
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[[Category: Perot J]]
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[[Category: Zarkadas, E]]
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[[Category: Zarkadas E]]
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[[Category: Antiemetic]]
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[[Category: Pentameric ligand-gated ion channel]]
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[[Category: Receptor]]
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[[Category: Transport protein]]
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Current revision

Mouse serotonin 5HT3 receptor in complex with palonosetron

6y1z, resolution 2.82Å

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OCA

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