3byx

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Current revision (14:53, 1 November 2023) (edit) (undo)
 
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<StructureSection load='3byx' size='340' side='right'caption='[[3byx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3byx' size='340' side='right'caption='[[3byx]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3byx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_a"_von_freudenreich_1890 "bacillus a" von freudenreich 1890]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3BYX FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3byx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lacticaseibacillus_casei Lacticaseibacillus casei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BYX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BYX FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C00:2-(4-HYDROXYBIPHENYL-3-YL)-4-METHYL-1H-ISOINDOLE-1,3(2H)-DIONE'>C00</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1lce|1lce]], [[1tsl|1tsl]], [[3bnz|3bnz]], [[3bz0|3bz0]], [[3c06|3c06]], [[3c0a|3c0a]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C00:2-(4-HYDROXYBIPHENYL-3-YL)-4-METHYL-1H-ISOINDOLE-1,3(2H)-DIONE'>C00</scene>, <scene name='pdbligand=UMP:2-DEOXYURIDINE+5-MONOPHOSPHATE'>UMP</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Thymidylate_synthase Thymidylate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.45 2.1.1.45] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3byx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3byx OCA], [https://pdbe.org/3byx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3byx RCSB], [https://www.ebi.ac.uk/pdbsum/3byx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3byx ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3byx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3byx OCA], [http://pdbe.org/3byx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3byx RCSB], [http://www.ebi.ac.uk/pdbsum/3byx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3byx ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA]] Provides the sole de novo source of dTMP for DNA biosynthesis.
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[https://www.uniprot.org/uniprot/TYSY_LACCA TYSY_LACCA] Provides the sole de novo source of dTMP for DNA biosynthesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus a von freudenreich 1890]]
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[[Category: Lacticaseibacillus casei]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Thymidylate synthase]]
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[[Category: Cancian L]]
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[[Category: Cancian, L]]
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[[Category: Costi MP]]
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[[Category: Costi, M P]]
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[[Category: Ferrari S]]
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[[Category: Ferrari, S]]
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[[Category: Leone R]]
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[[Category: Leone, R]]
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[[Category: Luciani R]]
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[[Category: Luciani, R]]
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[[Category: Mangani S]]
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[[Category: Mangani, S]]
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[[Category: Methyltransferase]]
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[[Category: Nucleotide biosynthesis]]
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[[Category: Structure based drug design]]
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[[Category: Transferase]]
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Current revision

Lactobacillus CASEI Thymidylate Synthase Ternary Complex with DUMP and the Phtalimidic Derivative C00 in Multiple Binding Modes

PDB ID 3byx

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