Hexokinase 3D structures
From Proteopedia
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**[[2e2q]] - StHK + ADP + xylose + Mg<br /> | **[[2e2q]] - StHK + ADP + xylose + Mg<br /> | ||
**[[3o5b]], [[3o8m]] – KlHK + glucose<br /> | **[[3o5b]], [[3o8m]] – KlHK + glucose<br /> | ||
| - | **[[1bdg]] – HK + glucose – ''Schistosoma mansoni'' | + | **[[1bdg]] – HK + glucose – ''Schistosoma mansoni''<br /> |
| + | **[[6krj]], [[6ksr]] - HK – ''Eimeria tenella''<br /> | ||
| + | **[[6da0]] - HK – ''Naegleria fowleri''<br /> | ||
| + | **[[6edi]] - HK – ''Leishmania braziliensis''<br /> | ||
| + | **[[7zzi]] - HK + glucose – Plasmodium falciparum<br /> | ||
*Hexokinase I | *Hexokinase I | ||
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**[[1dgk]] – hHK I (mutant) + ADP + glucose – human<br /> | **[[1dgk]] – hHK I (mutant) + ADP + glucose – human<br /> | ||
**[[1cza]] - hHK I (mutant) + ADP + glucose-6-phosphate + glucose<br /> | **[[1cza]] - hHK I (mutant) + ADP + glucose-6-phosphate + glucose<br /> | ||
| - | **[[1bg3]] - raHK I + glucose-6-phosphate + glucose - rat<br /> | ||
**[[1qha]] – hHK I + AMP-PNP<br /> | **[[1qha]] – hHK I + AMP-PNP<br /> | ||
**[[1hkc]] - hHK I + phosphate + glucose<br /> | **[[1hkc]] - hHK I + phosphate + glucose<br /> | ||
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**[[4foi]] - hHK I (mutant) + glucose 1,6-bisphosphate + glucose<br /> | **[[4foi]] - hHK I (mutant) + glucose 1,6-bisphosphate + glucose<br /> | ||
**[[4fpb]] - hHK I + 1,5-anhydroglucitol-6-phosphate + glucose<br /> | **[[4fpb]] - hHK I + 1,5-anhydroglucitol-6-phosphate + glucose<br /> | ||
| + | **[[1bg3]] - raHK I + glucose-6-phosphate + glucose - rat<br /> | ||
**[[4qs8]] - AtHK I – ''Arabidopsis thaliana''<br /> | **[[4qs8]] - AtHK I – ''Arabidopsis thaliana''<br /> | ||
**[[4qs7]] - AtHK I + glucose <br /> | **[[4qs7]] - AtHK I + glucose <br /> | ||
**[[4qs9]] - AtHK I (mutant) + glucose <br /> | **[[4qs9]] - AtHK I (mutant) + glucose <br /> | ||
**[[3b8a]] – yHK I + glucose – yeast<br /> | **[[3b8a]] – yHK I + glucose – yeast<br /> | ||
| - | **[[1hkg]] – yHK I<br /> | + | **[[1hkg]], [[6p4x]] – yHK I<br /> |
| + | **[[6pdt]] – yHK I + glucopyranose – Cryo EM<br /> | ||
| + | **[[6r2n]] - KlHK I <br /> | ||
*Hexokinase II or HK VI | *Hexokinase II or HK VI | ||
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**[[2nzt]] – hHK II <br /> | **[[2nzt]] – hHK II <br /> | ||
**[[5hex]], [[5hfu]], [[5hg1]] - hHK II + inhibitor <br /> | **[[5hex]], [[5hfu]], [[5hg1]] - hHK II + inhibitor <br /> | ||
| - | **[[ | + | **[[5zqt]], [[6jj4]] - rHK II - rice <br /> |
**[[6jj7]] - rHK II + glucose <br /> | **[[6jj7]] - rHK II + glucose <br /> | ||
**[[6jj8]] - rHK II + ATP<br /> | **[[6jj8]] - rHK II + ATP<br /> | ||
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*Hexokinase IV (Glucokinase GK) | *Hexokinase IV (Glucokinase GK) | ||
| - | **[[3qic]] – | + | **[[3qic]] – hGK IV residues 12-465 (mutant) <br /> |
**[[1v4t]] – hGK <br /> | **[[1v4t]] – hGK <br /> | ||
**[[3mcp]] – GK – ''Parabacterioides distasonis''<br /> | **[[3mcp]] – GK – ''Parabacterioides distasonis''<br /> | ||
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**[[4eun]] – GK – ''Janibacter''<br /> | **[[4eun]] – GK – ''Janibacter''<br /> | ||
**[[3vov]] – GK – ''Thermus thermophilus'' | **[[3vov]] – GK – ''Thermus thermophilus'' | ||
| + | **[[9f3n]], [[9f3o]] – KlGK <br /> | ||
*''Hexokinase IV binary complex'' | *''Hexokinase IV binary complex'' | ||
| - | **[[3idh]] - | + | **[[3idh]] - hGK IV residues 12-465 + glucose<br /> |
| - | **[[ | + | **[[1v4s]], [[3a0i]], [[3goi]], [[3h1v]], [[3imx]], [[3s41]], [[3vev]], [[3vf6]], [[4dch]], [[4dhy]] - hGK IV residues 12-465 + synthetic activator<br /> |
| - | **[[3fr0 | + | **[[3fr0]], [[4ise]], [[4isf]], [[4isg]], [[4iwv]], [[4ixc]], [[4l3q]], [[4mle]], [[4mlh]], [[5v4w]], [[5v4x]], [[6e0e]], [[6e0i]] - hGK IV residues 12-465 + activator<br /> |
**[[1sz2]] - EcGK + glucose<br /> | **[[1sz2]] - EcGK + glucose<br /> | ||
**[[3vgm]] - SgGK + glucose<br /> | **[[3vgm]] - SgGK + glucose<br /> | ||
| + | **[[9f3i]] - KlGK + glucose<br /> | ||
| + | **[[9f3k]] - KlGK (mutant) + glucose<br /> | ||
| + | **[[9f3m]] - KlGK (mutant) + fructose<br /> | ||
| + | **[[9f3j]] - KlGK + mannose<br /> | ||
| + | **[[9f3l]] - KlGK (mutant) + mannose<br /> | ||
*''Hexokinase IV ternary complex'' | *''Hexokinase IV ternary complex'' | ||
**[[3vey]] - hGK + glucose + ATPgS<br /> | **[[3vey]] - hGK + glucose + ATPgS<br /> | ||
| - | **[[ | + | **[[7t78]], [[7t79]] - hGK IV + glucose + ligand<br /> |
| - | **[[3f9m]], [[4l3q]], [[4no7]], [[4rch]] - | + | **[[3fgu]], [[3id8]] - hGK IV residues 12-465 + AMP-PNP + glucose<br /> |
| - | **[[ | + | **[[3f9m]], [[4l3q]], [[4no7]], [[4rch]] - hGK IV residues 12-465 + activator + glucose<br /> |
| + | **[[3w0l]], [[4lc9]] – raGK + fructose-6-phosphate + GK regulator<br /> | ||
**[[2q2r]] - GK + glucose + ADP – ''Trypanosoma cruzi''<br /> | **[[2q2r]] - GK + glucose + ADP – ''Trypanosoma cruzi''<br /> | ||
**[[3vgl]] - SgGK + glucose + AMP-PNP<BR /> | **[[3vgl]] - SgGK + glucose + AMP-PNP<BR /> | ||
Current revision
3D structures of hexokinase
Updated on 26-August-2025
