7cj2

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'''Unreleased structure'''
 
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The entry 7cj2 is ON HOLD until Jan 09 2022
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==Crystal structure of the Fab antibody complexed with human YKL-40==
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<StructureSection load='7cj2' size='340' side='right'caption='[[7cj2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7cj2]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CJ2 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cj2 OCA], [https://pdbe.org/7cj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cj2 RCSB], [https://www.ebi.ac.uk/pdbsum/7cj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cj2 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] A genetic variation in CHI3L1 is associated with susceptibility to asthma-related traits type 7 (ASRT7) [MIM:[https://omim.org/entry/611960 611960]. Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing and dyspnea, bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test, serum IgE levels, atopy, and atopic dermatitis.
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== Function ==
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[https://www.uniprot.org/uniprot/CH3L1_HUMAN CH3L1_HUMAN] Carbohydrate-binding lectin with a preference for chitin. May play a role in defense against pathogens, or in tissue remodeling. May play an important role in the capacity of cells to respond to and cope with changes in their environment.<ref>PMID:9492324</ref>
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Authors: Choi, S., Na, J.H., Lee, S.J., Woo, J.R., Kim, D.Y., Hong, J.T., Lee, W.K.
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==See Also==
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*[[Antibody 3D structures|Antibody 3D structures]]
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Description: Crystal structure of the Fab antibody complexed with human YKL-40
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*[[Chitinase-3-like protein 3D structures|Chitinase-3-like protein 3D structures]]
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[[Category: Unreleased Structures]]
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== References ==
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[[Category: Kim, D.Y]]
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<references/>
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[[Category: Woo, J.R]]
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__TOC__
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[[Category: Choi, S]]
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</StructureSection>
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[[Category: Lee, S.J]]
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[[Category: Homo sapiens]]
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[[Category: Lee, W.K]]
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[[Category: Large Structures]]
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[[Category: Na, J.H]]
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[[Category: Choi S]]
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[[Category: Hong, J.T]]
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[[Category: Hong JT]]
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[[Category: Kim DY]]
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[[Category: Lee SJ]]
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[[Category: Lee WK]]
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[[Category: Na JH]]
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[[Category: Woo JR]]

Current revision

Crystal structure of the Fab antibody complexed with human YKL-40

PDB ID 7cj2

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OCA

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