6vnz

<StructureSection load='6vnz' size='340' side='right'caption='[[6vnz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[6vnz]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buthus_tamalus Buthus tamalus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6VNZ OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6VNZ FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6vnz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6vnz OCA], [http://pdbe.org/6vnz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6vnz RCSB], [http://www.ebi.ac.uk/pdbsum/6vnz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6vnz ProSAT]</span></td></tr>

== Function ==

[[http://www.uniprot.org/uniprot/KAX54_HOTTA KAX54_HOTTA]] Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).<ref>PMID:12239213</ref>

[[Category: Buthus tamalus]]

[[Category: Flores, M Mayorga]]

[[Category: Meneses, C M.Melchor]]

[[Category: Portilla, F del Rio]]

[[Category: Toxin]]