Hydroxysteroid dehydrogenase 3D structures
From Proteopedia
(Difference between revisions)
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**[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR /> | **[[1fjh]] - CtHSD – ''Comamonas testosterone''<BR /> | ||
**[[4is2]] – CsHSD – ''Clostridium scindens''<br /> | **[[4is2]] – CsHSD – ''Clostridium scindens''<br /> | ||
| + | **[[7p36]], [[8kc6]] - LkHSD – ''Lactobacillus kefiri''<br /> | ||
| + | **[[8kcn]] - LkHSD (mutant)<br /> | ||
*''3-α HSD binary complex'' | *''3-α HSD binary complex'' | ||
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**[[2dkn]] - HSD + NAD – ''Pseudomonas''<BR /> | **[[2dkn]] - HSD + NAD – ''Pseudomonas''<BR /> | ||
**[[4is3]] - CsHSD + NAD<br /> | **[[4is3]] - CsHSD + NAD<br /> | ||
| + | **[[7ejh]], [[7eji]], [[7ejj]], [[7vdo]], [[7vet]] - LkHSD (mutant`) + NADP <br /> | ||
*''3-α HSD ternary complex'' | *''3-α HSD ternary complex'' | ||
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*7-α HSD | *7-α HSD | ||
| - | **[[3gaf]] - | + | **[[3gaf]] - BmHSD – ''Brucella melitensis''<BR /> |
| - | **[[ | + | **[[8hax]], [[8hde]], [[8hdi]], [[8hdn]], [[8hs6]], [[8hs9]] - BmHSD (mutant)<BR /> |
| - | **[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD | + | **[[8hs4]], [[8hs5]], [[8hsa]] - BmHSD (mutant) + NAD<BR /> |
| + | **[[7eny]] – EcHSD – ''Escherichia coli''<br /> | ||
| + | **[[1ahh]] – EcHSD + NAD <BR /> | ||
| + | **[[1ahi]], [[1fmc]] – EcHSD + hydroxysteroid + NAD<br /> | ||
| + | **[[5epo]] – HSD + NADP – ''Clostridium sardiniese''<br /> | ||
| + | |||
| + | *7-beta HSD | ||
| + | |||
| + | **[[5fyd]] – CaHSD – ''Collinsella aerofaciens<''br /> | ||
| + | **[[5gt9]] – CaHSD + NADP<br /> | ||
*20-α HSD or AKR1C1 | *20-α HSD or AKR1C1 | ||
| + | **[[6a7a]], [[8jp2]] – hHSD + NADP + inhibitor<br /> | ||
**[[1q5m]] - raHSD + NADP – rabbit | **[[1q5m]] - raHSD + NADP – rabbit | ||
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**[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR /> | **[[3c3u]], [[3nty]] - hHSD + inhibitor + NADP<BR /> | ||
**[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR /> | **[[3gug]] - hHSD (mutant) + inhibitor + NADP<BR /> | ||
| + | **[[6ijx]] – hHSD + NADP + meclofenamic acid<br /> | ||
**[[1q13]] - raHSD + hydroxysteroid + NADP<BR /> | **[[1q13]] - raHSD + hydroxysteroid + NADP<BR /> | ||
| + | |||
| + | *20-beta HSD | ||
| + | |||
| + | **[[6m9u]] – BaHSD – ''Bifidobacterium adolescentis''<br /> | ||
| + | **[[6ow4]] – BaHSD + NADP <br /> | ||
*11-β HSD or corticosteroid 11-β-dehydrogenase 1 | *11-β HSD or corticosteroid 11-β-dehydrogenase 1 | ||
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**[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR /> | **[[2bel]] - hHSD 1 + hydroxysteroid + NADP<BR /> | ||
| - | **[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]] - hHSD 1 + inhibitor + NADP<BR /> | + | **[[2irw]], [[2ilt]], [[4bb5]], [[4bb6]], [[4yyz]] - hHSD 1 + inhibitor + NADP<BR /> |
| - | **[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[ | + | **[[2rbe]], [[3byz]], [[3bzu]], [[3ch6]], [[3czr]], [[3d3e]], [[3d4n]], [[3d5q]], [[3ey4]], [[3fco]], [[3frj]], [[3h6k]], [[3hfg]], [[3oq1]], [[3pdj]], [[3qqp]], [[3tfq]], [[4c7j]], [[4c7k]], [[4p38]], [[5pgu]], [[5pgv]], [[5pgw]], [[5pgx]], [[5pgy]], [[5pgz]], [[5pii]], [[5pij]], [[5qii]] - hHSD 1 (mutant) + inhibitor + NADP<BR /> |
**[[6nj7]] - hHSD 1 + colleic acid + NAP<br /> | **[[6nj7]] - hHSD 1 + colleic acid + NAP<br /> | ||
**[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR /> | **[[3g49]] - gpHSD catalytic domain + inhibitor + NADP<BR /> | ||
**[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR /> | **[[1y5r]], [[3gmd]] - mHSD 1 + hydroxysteroid + NADP<BR /> | ||
| - | **[[4k26]] - mHSD 1 + inhibitor + NADP<br /> | + | **[[4k26]], [[5qij]] - mHSD 1 + inhibitor + NADP<br /> |
**[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br /> | **[[4nmh]] - mHSD 1 (mutant) + inhibitor + NADP<br /> | ||
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**[[2he8]] – mHSD - mouse <br /> | **[[2he8]] – mHSD - mouse <br /> | ||
**[[3fjn]] - mHSD (mutant) <br /> | **[[3fjn]] - mHSD (mutant) <br /> | ||
| - | **[[ | + | **[[2he5]], [[2hej]], [[2p5n]] - mHSD + NADP <br /> |
**[[2ipf]] - mHSD + hydroxysteroid + NADP <br /> | **[[2ipf]] - mHSD + hydroxysteroid + NADP <br /> | ||
**[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br /> | **[[2ipg]], [[2ipj]] - mHSD (mutant) + hydroxysteroid + NADP<br /> | ||
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**[[1bhs]] – hHSD 1 <BR /> | **[[1bhs]] – hHSD 1 <BR /> | ||
**[[1s9c]] - hHSD 4 (mutant) <BR /> | **[[1s9c]] - hHSD 4 (mutant) <BR /> | ||
| + | **[[8g9v]] – hHSD 13 <BR /> | ||
**[[5ics]] – hHSD 14 <BR /> | **[[5ics]] – hHSD 14 <BR /> | ||
**[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR /> | **[[3is3]] – ClHSD – ''Cochliobolus lunatus''<BR /> | ||
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*''17-β HSD binary complex'' | *''17-β HSD binary complex'' | ||
| - | **[[ | + | **[[1fds]], [[1iol]], [[1jtv]], [[1yb1]], [[3dhe]], [[3klm]], [[3klp]], [[3km0]] - hHSD + hydroxysteroid<br /> |
| - | **[[ | + | **[[1dht]], [[1fdw]] - hHSD (mutant) + hydroxysteroid<BR /> |
**[[6mnc]] – hHSD 1 + estrone<br /> | **[[6mnc]] – hHSD 1 + estrone<br /> | ||
**[[1fdv]] - hHSD 1 (mutant) + NAD<BR /> | **[[1fdv]] - hHSD 1 (mutant) + NAD<BR /> | ||
| - | **[[1qyv]] - hHSD 1 + NADP<BR /> | + | **[[1equ]], [[1qyv]] - hHSD 1 + NADP<BR /> |
**[[1i5r]], [[6dtp]] - hHSD 1 + inhibitor<br /> | **[[1i5r]], [[6dtp]] - hHSD 1 + inhibitor<br /> | ||
**[[1zbq]] - hHSD 4 + NAD<BR /> | **[[1zbq]] - hHSD 4 + NAD<BR /> | ||
| - | **[[ | + | **[[2o23]] – hHSD 10 + NAD<br /> |
| - | **[[ | + | **[[5en4]], [[5icm]], [[5l7t]], [[5l7w]], [[5l7y]] - hHSD 14 + inhibitor<br /> |
| + | **[[5js6]], [[5jsf]], [[6h0m]], [[6hno]] - hHSD 14 (mutant) + NAD<br /> | ||
| + | **[[8g93]] - HSD 13 (mutant) + NAD - dog<BR /> | ||
**[[3qwf]] - ClHSD + NADP<BR /> | **[[3qwf]] - ClHSD + NADP<BR /> | ||
| - | **[[ | + | **[[4fiz]], [[4fj0]], [[4fj1]], [[4fj2]] – ClHSD + dehydroxy flavonoid inhibitor<br /> |
*''17-β HSD ternary complex'' | *''17-β HSD ternary complex'' | ||
| - | **[[ | + | **[[1fdt]], [[1qyw]], [[1qyx]] - hHSD 1 + hydroxysteroid + NADP<BR /> |
**[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR /> | **[[1a27]], [[1fdu]] - hHSD 1 (mutant) + hydroxysteroid + NADP<BR /> | ||
**[[3hb5]], [[6cge]] - hHSD 1 + inhibitor + NADP<BR /> | **[[3hb5]], [[6cge]] - hHSD 1 + inhibitor + NADP<BR /> | ||
**[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]], [[6cgc]] - hHSD 1 (mutant) + inhibitor + NADP<br /> | **[[4hfr]], [[4hx5]], [[4iju]], [[4ijv]], [[4ijw]], [[4k1l]], [[6cgc]] - hHSD 1 (mutant) + inhibitor + NADP<br /> | ||
| - | **[[6mne]] – hHSD 1 + NADP + estrone<br /> | + | **[[6mne]], [[7x3z]] – hHSD 1 + NADP + estrone<br /> |
**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br /> | **[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]] - hHSD 14 + inhibitor + NAD<br /> | ||
**[[5hs6]] - hHSD + NAD + estrone<br /> | **[[5hs6]] - hHSD + NAD + estrone<br /> | ||
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**[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br /> | **[[4cqm]] - hHSD 8 + carbonyl reductase + NADP<br /> | ||
**[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]], [[6qck]] - hHSD 14 + inhibitor + NAD<br /> | **[[5o42]], [[5o43]], [[5o6o]], [[5o6x]], [[5o6z]], [[5o72]], [[6qck]] - hHSD 14 + inhibitor + NAD<br /> | ||
| - | **[[6ffb]], [[6g4l]], [[6gtu]], [[ | + | **[[5o7c]], [[6ffb]], [[6g4l]], [[6gbt]], [[6gtb]], [[6gtu]], [[6zde]], [[6zdi]], [[6zr6]], [[6zra]], [[6zt2]] - hHSD 14 (mutant) + inhibitor + NAD<br /> |
**[[6emm]] - hHSD 14 (mutant) + salicilate + NAD<br /> | **[[6emm]] - hHSD 14 (mutant) + salicilate + NAD<br /> | ||
**[[5hs6]] - hHSD 14 + NAD + estrone<br /> | **[[5hs6]] - hHSD 14 + NAD + estrone<br /> | ||
| - | **[[ | + | **[[3qwh]], [[3qwi]] - ClHSD + hydroxysteroid + NADP<BR /> |
*3-α 20-β HSD | *3-α 20-β HSD | ||
Current revision
3D structures of hydroxysteroid dehydrogenase
Updated on 17-September-2025
For 3-α HSD type 2 see Prostaglandin F synthase
For 17-β HSD type 5 or AKR1C3 see Prostaglandin F synthase
