Interleukin 3D structures

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Line 10: Line 10:
**[[2l5x]] – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR<BR />
**[[2l5x]] – hIL-1 α residues 121-271 + calcium-binding protein A13 – NMR<BR />
-
*IL-1 β
+
*Mature IL-1 β (residues 117-269)
-
**[[2nvh]], [[9ilb]], [[1iob]], [[5i1b]], [[2i1b]], [[4i1b]], [[1i1b]] - hIL-1 β<br />
+
**[[1i1b]], [[1iob]], [[2i1b]], [[2nvh]], [[3ltq]], [[4ilb]], [[5i1b]], [[8rys]], [[9i1b]] - hIL-1 β
-
**[[1tp0]], [[1t4q]], [[1too]], [[1twe]], [[1twm]], [[1s0l]], [[1l2h]], [[1hib]], [[21bi]], [[31bi]], [[41bi]] - hIL-1 β (mutant) <BR />
+
**[[3ltq]], [[8rys]] - hIL-1 β <BR />
**[[6i1b]], [[7i1b]] - hIL-1 β - NMR<BR />
**[[6i1b]], [[7i1b]] - hIL-1 β - NMR<BR />
-
**[[3ltq]] - hIL-1 β residues 117-269 <BR />
+
**[[1hib]], [[1l2h]], [[1s0l]], [[1t4q]], [[1tp0]], [[1too]], [[1twe]], [[1twm]], [[21bi]], [[31bi]], [[3pok]], [[41bi]] - hIL-1 β (mutant) <BR />
-
**[[3pok]] - hIL-1 β residues 117-269 (mutant) <BR />
+
**[[6y8i]], [[6y8m]], [[8c3u]], [[8rzb]] - hIL-1 β + pyridine derivative<BR />
-
**[[6y8i]], [[6y8m]] - hIL-1 β residues 117-269 + pyridine derivative<BR />
+
**[[8ryk]] - hIL-1 β + peptide<BR />
**[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain<BR />
**[[1itb]] - hIL-1 β + IL-1 receptor 1 extracellular domain<BR />
**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
**[[3o4o]] - hIL-1 β + IL-1 receptor 2 + IL-1 receptor accessory protein<BR />
**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />
**[[4dep]] - hIL-1 β + IL-1 receptor 1 + IL-1 receptor accessory protein<BR />
-
**[[4g6j]], [[4g6m]], [[5bvp]] - hIL-1 β + antibody<br />
+
**[[4g6j]], [[4g6m]], [[5bvp]], [[7chy]], [[7chz]], [[7z4t]] - hIL-1 β + antibody<br />
-
**[[2kh2]] - hIL-1 β + SCFV - NMR<BR />
+
**[[2kh2]] - hIL-1 β + scFv - NMR<BR />
-
**[[1md6]] – mIL-1F5 – mouse<BR />
+
**[[2mib]], [[8i1b]] - mIL-1 β - mouse
-
**[[2mib]], [[8i1b]] - mIL-1 β<br />
+
**[[2wry]] - cIL-1 β – chicken<BR />
**[[2wry]] - cIL-1 β – chicken<BR />
-
**[[3nj5]], [[4x3a]], [[4x39]], [[4x38]], [[4x37]] – cIL-1 β (mutant) <BR />
+
**[[3nj5]], [[4x37]], [[4x38]], [[4x39]], [[4x3a]] – cIL-1 β (mutant) <BR />
*IL-2 (T-cell growth factor)
*IL-2 (T-cell growth factor)
**[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />
**[[1m47]], [[1m4c]], [[3ink]] – hIL-2<BR />
-
**[[3qb1]] - hIL-2 (mutant)<br />
+
**[[3qb1]], [[7m2g]], [[7ra9]], [[7raa]] - hIL-2 (mutant)<br />
**[[1irl]] – hIL-2 (mutant) - NMR<BR />
**[[1irl]] – hIL-2 (mutant) - NMR<BR />
**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ<BR />
**[[5m5e]] - hIL-2 + IL-2 receptor β + cytokine receptor common γ<BR />
Line 40: Line 39:
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
**[[1pw6]], [[1py2]], [[1m48]], [[1m49]] – hIL-2 + inhibitor<BR />
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
**[[4nej]], [[4nem]] – hIL-2 + methylfuran carboxylate derivative<BR />
-
**[[5lqb]] - hIL-2 + antibody<br />
+
**[[5lqb]], [[6ye3]], [[7dr4]] - hIL-2 + antibody<br />
 +
**[[8sow]], [[8soz]] - hIL-2 + scFv<br />
 +
**[[7zmz]] - hIL-2 + CD25<br />
**[[4yue]] - mIL-2 + antibody<br />
**[[4yue]] - mIL-2 + antibody<br />
**[[4yqx]] - IL-2 + antibody - rat<br />
**[[4yqx]] - IL-2 + antibody - rat<br />
**[[4zf7]] – hIL-2 - ferret<BR />
**[[4zf7]] – hIL-2 - ferret<BR />
 +
**[[7cjn]], [[7d9m]] – IL-2 – grass carp<BR />
*IL-3
*IL-3
Line 54: Line 56:
*IL-4
*IL-4
-
**[[2b8u]], [[1hik]], [[2int]], [[1rcb]] – hIL-4<BR />
+
**[[1hik]], [[1rcb]], [[2b8u]], [[2int]] – hIL-4<BR />
-
**[[2cyk]], [[1cyl]], [[1itm]], [[1bbn]], [[1bcn]], [[1iti]], [[1itl]] – hIL-4 - NMR<BR />
+
**[[1bbn]], [[1bcn]], [[1cyl]], [[1iti]], [[1itl]], [[1itm]], [[2cyk]], [[8cgf]], [[8ch7]] – hIL-4 - NMR<BR />
-
**[[2b8x]], [[2b8y]], [[2b8z]], [[2b90]], [[2b91]], [[2d48]], [[1hzi]], [[1hij]] - hIL-4 (mutant) <BR />
+
**[[1hij]], [[1hzi]], [[2b8x]], [[2b8y]], [[2b8z]], [[2b90]], [[2b91]], [[2d48]], [[8a4f]] - hIL-4 (mutant) <BR />
**[[5fhx]] - hIL-4 + antibody<BR />
**[[5fhx]] - hIL-4 + antibody<BR />
**[[1iar]] - hIL-4 + IL-4 receptor α (mutant) <BR />
**[[1iar]] - hIL-4 + IL-4 receptor α (mutant) <BR />
Line 70: Line 72:
**[[3qt2]] - hIL-5 + IL-5 receptor α (mutant) <BR />
**[[3qt2]] - hIL-5 + IL-5 receptor α (mutant) <BR />
**[[3va2]] - hIL-5 + IL-5 receptor α <BR />
**[[3va2]] - hIL-5 + IL-5 receptor α <BR />
 +
**[[8tld]] - hIL-5 + IL-5 receptor α + cytokine receptor subunit beta – Cryo EM <BR />
**[[3b5k]] – mIL-5<br />
**[[3b5k]] – mIL-5<br />
*IL-6
*IL-6
-
**[[1alu]] – hIL-6<BR />
+
**[[1alu]], [[7nxz]] – hIL-6<BR />
**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
**[[1il6]], [[2il6]] – hIL-6 - NMR<BR />
 +
**[[8qy6]] – hIL-6 – Cryo EM<BR />
**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
**[[1p9m]] - hIL-6 + IL-6 receptor α and β<br />
 +
**[[8d82]], [[8qy5]] - hIL-6 + IL-6 receptor α and β – Cryo EM<br />
**[[5fuc]] - hIL-6 + IL-6 receptor α + VHH6<br />
**[[5fuc]] - hIL-6 + IL-6 receptor α + VHH6<br />
**[[4j4l]] – hIL-6 + internalin B<BR />
**[[4j4l]] – hIL-6 + internalin B<BR />
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
**[[4ni7]], [[4ni9]] – hIL-6 + nucleotide aptamer<BR />
-
**[[4cni]], [[4o9h]], [[4zs7]] – hIL-6 + antibody<BR />
+
**[[4cni]], [[4o9h]], [[4zs7]], [[8ywq]] – hIL-6 + antibody<BR />
 +
**[[8ywr]] – hIL-6 42-212 + antibody<BR />
**[[2l3y]] - mIL-6 residues 27-211 - NMR<br />
**[[2l3y]] - mIL-6 residues 27-211 - NMR<br />
-
**[[1i16]] – IL-6 + IL-6 receptor β - Herpesvirus 8<br />
+
**[[1i16]] – IL-6 + IL-6 receptor β - Herpesvirus 8
 +
**[[8upa]] – sIL-6 1-56 + hIL-6 receptor β – synthetic<br />
*IL-7
*IL-7
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**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
**[[1ikl]], [[1ikm]] - hIL-8 (mutant) - NMR<BR />
**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99<BR />
**[[3il8]], [[5d14]], [[4xdx]] – hIL-8 residues 28-99<BR />
 +
**[[6xmn]] – hIL-8 residues 28-93 + CXCR1 N-terminal - NMR<BR />
**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />
**[[1rod]] - hIL-8/melanoma growth stimulating protein – NMR<br />
-
**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide
+
**[[1ilp]], [[1ilq]] - hIL-8 + IL-8 receptor peptide<br />
 +
**[[6wzm]] – hIL-8 + antibody<BR />
 +
**[[6lfm]], [[6lfo]]– hIL-8 in G-protein coupled receptor – Cryo EM<br />
 +
 
 +
*IL-9
 +
 
 +
**[[7ox6]] – hIL-9 - NMR<BR />
 +
**[[7ox5]] - hIL-9 + IL—9 receptor a<br />
 +
**[[7ox1]], [[7ox2]], [[7ox3]] - hIL-9 + antibody<br />
 +
**[[7xcb]] – mIL-9 <BR />
 +
**[[7ox4]] – mIL-9 + antibody<BR />
*IL-10
*IL-10
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**[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR />
**[[1j7v]] – hIL-10 + IL-10 receptor α (mutant) <BR />
**[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α<br />
**[[1y6k]] - hIL-10 residues 19-178 + IL-10 receptor α<br />
 +
**[[8sve]] – hIL-10 + antibody<BR />
**[[4x51]] – mIL-10<BR />
**[[4x51]] – mIL-10<BR />
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**[[4mhl]] - hIL-11<br />
**[[4mhl]] - hIL-11<br />
 +
**[[8dpv]], [[8dpw]] - hIL-11 (mutant) <br />
 +
**[[8qy4]] - hIL-11 (mutant) – Cryo EM<br />
 +
**[[8dpu]] - hIL-11 + hILR-11 alpha+beta <br />
 +
**[[8dps]] - hIL-11 + hILR-11 alpha+beta – Cryo EM<br />
 +
**[[8dpt]] - hIL-11 + hILR-11 alpha (mutant) + hILR-6 – Cryo EM<br />
*IL-12
*IL-12
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**[[1f42]] - hIL-12 β P40 domain<BR />
**[[1f42]] - hIL-12 β P40 domain<BR />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
**[[3hmx]] - hIL-12 α and β+ antibody<br />
 +
**[[8pb1]], [[8yi7]] - hIL-12 α and β+ hILR-12 α and β – Cryo EM<br />
 +
**[[8oe0]], [[8xrp]] – hIL-12 α and β + hIL12R beta1 and beta2 – Cryo EM<br />
**[[5mj3]], [[5mj4]], [[5njd]] - hIL-12 β + hIL-23 α + antibody<br />
**[[5mj3]], [[5mj4]], [[5njd]] - hIL-12 β + hIL-23 α + antibody<br />
**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody<br />
**[[5mzv]] - hIL-12 β + hIL-23 α + hIL-23 receptor + antibody<br />
-
**[[5mxa]] - hIL-12 β + hIL- 23 α<br />
+
**[[6wdq]] - hIL-12 β + hIL-23 α + hIL-12 receptor + hIL-23 receptor <br />
-
**[[5mj3]], [[5mj4]] - hIL-12 β + hIL-23 α + alphabody MB3<br />
+
**[[8oe4]] - hIL-12 β + hIL-23 α + hIL-12 receptor + hIL-23 receptor – Cryo EM <br />
 +
**[[5mxa]], [[8cr8]] - hIL-12 β + hIL- 23 α<br />
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />
**[[3qwr]] - hIL-12 β + hIL- 23 α + adnectin<br />
-
**[[6uib]] - hIL-12 β + hIL- 23 α + peptide<br />
+
**[[6uib]], [[8uui]] - hIL-12 β + hIL- 23 α + peptide<br />
-
**[[6sff]] - mIL-12 β <br />
+
**[[8cr6]] - mIL-12 alpha + beta subunits <br />
 +
**[[6sff]], [[6smc]], [[6sp3]], [[7pur]], [[7r3n]] - mIL-12 β <br />
 +
**[[8cr5]] - mIL-12 alpha+β + mILR-12 beta1+ beta2 – Cryo EM<br />
 +
**[[8odz]] - mIL-12 β + mILR-12 beta1 <br />
*IL-13
*IL-13
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**[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
**[[3lb6]] - hIL-13 + IL-13 receptor α2<BR />
**[[3bpo]], [[5e4e]] - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α<br />
**[[3bpo]], [[5e4e]] - hIL-13 residues 20-145 + IL-4 receptor α + IL-13 receptor α<br />
-
**[[5l6y]] - hIL-13 + antibody<br />
+
**[[5l6y]], [[7rew]] - hIL-13 + antibody<br />
 +
**[[8blq]] - hIL-13 + antibody – Cryo EM<br />
*IL-15
*IL-15
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**[[4hr9]] - hIL-17A (mutant)<br />
**[[4hr9]] - hIL-17A (mutant)<br />
**[[5n92]] - hIL-17A + hIL-17F <br />
**[[5n92]] - hIL-17A + hIL-17F <br />
 +
**[[7uwm]] - hIL-17A + IL-17A receptor α – Cryo EM<br />
**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
**[[4hsa]] - hIL-17A (mutant) + IL-17A receptor α <br />
**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α <br />
**[[5nan]] - hIL-17A + hIL-17F + IL-17A receptor α <br />
-
**[[2vxs]], [[4qhu]] - hIL-17A + antibody<BR />
+
**[[7uwn]] - hIL-17A + IL-17A receptor α + IL-17A receptor gamma<br />
 +
**[[7zan]] - hIL-17A (mutant) + IL-17A receptor α + IL-17A receptor gamma<br />
 +
**[[2vxs]], [[4qhu]], [[6wio]], [[6wir]], [[7wkx]], [[7z2m]] - hIL-17A + antibody<BR />
 +
**[[8b7w]], [[8dy1]], [[8dy5]] - hIL-17A + scFv<BR />
 +
**[[8dyf]], [[8dyg]], [[8dyh]], [[8dyi]], [[8usr]], [[8uss]], [[9fkx]], [[9fl3]], [[9h4d]], [[9h4o]] - hIL-17A + inhibitor<BR />
**[[5vb9]] - hIL-17A + peptide inhibitor<BR />
**[[5vb9]] - hIL-17A + peptide inhibitor<BR />
 +
**[[8cdg]] - hIL-17A + macrocycle inhibitor<BR />
 +
**[[7ama]], [[7amg]] - hIL-17A + modulator<br />
**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />
**[[5hi5]], [[5hi4]], [[5hi3]], [[5hhx]], [[5hhv]] - hIL-17A + peptide inhibitor + antibody<BR />
**[[1jpy]], [[6hgo]] – hIL-17F<BR />
**[[1jpy]], [[6hgo]] – hIL-17F<BR />
-
**[[6ppg]] – hIL-17F + antibody<BR />
+
**[[6ppg]], [[8ruu]] – hIL-17F + antibody<BR />
**[[3jvf]], [[6hg4]], [[6hg9]] - hIL-17F + IL-17 receptor α
**[[3jvf]], [[6hg4]], [[6hg9]] - hIL-17F + IL-17 receptor α
Line 166: Line 204:
**[[3wo2]] – hIL-18 <BR />
**[[3wo2]] – hIL-18 <BR />
-
**[[4xfu]], [[4xft]], [[4xfs]] - hIL-18 (mutant) <BR />
+
**[[4xfs]], [[4xft]], [[4xfu]], [[9od7]], [[9od9]] - hIL-18 (mutant) <BR />
-
**[[1j0s]] – hIL-18 - NMR<BR />
+
**[[1j0s]], [[8urv]] – hIL-18 - NMR<BR />
**[[4hjj]] - hIL-18 + antibody<br />
**[[4hjj]] - hIL-18 + antibody<br />
**[[2vxt]] - hIL-18 (mutant) + antibody<BR />
**[[2vxt]] - hIL-18 (mutant) + antibody<BR />
Line 174: Line 212:
**[[3wo3]], [[4r6u]] - hIL-18 + IL-18 receptor<br />
**[[3wo3]], [[4r6u]] - hIL-18 + IL-18 receptor<br />
**[[3wo4]] - hIL-18 + IL-18 receptor + IL-18 receptor accessory protein<br />
**[[3wo4]] - hIL-18 + IL-18 receptor + IL-18 receptor accessory protein<br />
 +
**[[8j6k]], [[8spb]], [[8sv1]] - hIL-18 + caspase P10, P20 subunits<br />
*IL-19
*IL-19
Line 187: Line 226:
**[[2oqp]]– hIL-21 – NMR<BR />
**[[2oqp]]– hIL-21 – NMR<BR />
**[[3tgx]] - hIL-21 + IL-21 receptor α (mutant) <BR />
**[[3tgx]] - hIL-21 + IL-21 receptor α (mutant) <BR />
 +
**[[9e2t]] - hIL-21 (mutant) + ILR-21 + ILR-2 gamma<BR />
 +
**[[8ent]] - hIL-21 (mutant) + ILR-21 (mutant) + ILR-2 gamma (mutant) <BR />
*IL-22
*IL-22
Line 194: Line 235:
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
**[[3dlq]], [[3dgc]] - hIL-22 residues 29-179 (mutant) + IL-22 receptor α1<br />
**[[3q1s]] - hIL-22 residues 29-179 (mutant) + antibody<br />
**[[3q1s]] - hIL-22 residues 29-179 (mutant) + antibody<br />
 +
**[[6weo]] - hIL-22 + IL-22 receptor + IL-10 receptor <br />
**[[4o6k]] – IL-22 – zebra fish<BR />
**[[4o6k]] – IL-22 – zebra fish<BR />
Line 207: Line 249:
**[[6gg1]] - hIL-24<br />
**[[6gg1]] - hIL-24<br />
**[[6df3]] - hIL-24 + IL—22 receptor α1 + IL-20 receptor β<br />
**[[6df3]] - hIL-24 + IL—22 receptor α1 + IL-20 receptor β<br />
 +
 +
*IL-25
 +
 +
**[[7uwj]], [[7uwk]] - hIL-25 + IL—17 receptor b – Cryo EM<br />
 +
**[[7uwl]] - hIL-25 + IL—17 receptor a + IL—17 receptor b – Cryo EM<br />
 +
 +
*IL-27
 +
 +
**[[8xwy]] - hIL-27 α and β <br />
 +
**[[7u7n]], [[8d85]] - hIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM<br />
 +
**[[7zxk]] - hIL-27 + antibody<br />
 +
**[[7zg0]] - mIL-27 + IL—27 receptor a <br />
 +
**[[7z0l]] - mIL-27 + IL—27 receptor a + IL-6 receptor b – Cryo EM<br />
*IL-28
*IL-28
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**[[2kll]] - hIL-33 residues 110-270 - NMR<BR />
**[[2kll]] - hIL-33 residues 110-270 - NMR<BR />
 +
**[[4kc3]] - hIL-33 + IL—1 receptor-like 1<br />
 +
**[[5iv4]] - mIL-33 + IL—1 receptor-like 1 + IL-1 receptor accessory protein<br />
 +
**[[8q5r]] - mIL-33 + alarmin release inhibitor<br />
*IL-34
*IL-34
Line 238: Line 296:
**[[6ncu]], [[5hn1]] - hIL-37<br />
**[[6ncu]], [[5hn1]] - hIL-37<br />
 +
 +
*IL-38
 +
 +
**[[8q3j]] - mIL-38 + antibody<br />
 +
 +
}}
}}
[[Category: Topic Page]]
[[Category: Topic Page]]

Current revision

3D structures of interleukin

Updated on 05-October-2025

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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