6xqk

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'''Unreleased structure'''
 
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The entry 6xqk is ON HOLD until Paper Publication
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==Crystal structure of the D/D domain of PKA from S. cerevisiae==
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<StructureSection load='6xqk' size='340' side='right'caption='[[6xqk]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6xqk]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XQK FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xqk OCA], [https://pdbe.org/6xqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xqk RCSB], [https://www.ebi.ac.uk/pdbsum/6xqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xqk ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAPR_YEAST KAPR_YEAST] Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), an effector of the Ras/cAMP pathway. Inhibits PKA activity in the absence of cAMP. cAMP activates PKA and promotes growth and proliferation in response to good nutrient conditions. Together with ZDS1, provides a negative feedback control on the cell wall integrity-signaling pathway by acting as a negative regulator of MAP kinase SLT2/MPK1.<ref>PMID:3037314</ref> <ref>PMID:2823100</ref> <ref>PMID:6243658</ref> <ref>PMID:12704202</ref>
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Authors: Larrieux, N., Gonzalez Bardeci, N., Trajtenberg, F., Buschiazzo, A.
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==See Also==
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
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Description: Crystal structure of the D/D domain of PKA from S. cerevisiae
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Buschiazzo, A]]
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__TOC__
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[[Category: Gonzalez Bardeci, N]]
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</StructureSection>
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[[Category: Larrieux, N]]
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[[Category: Large Structures]]
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[[Category: Trajtenberg, F]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Buschiazzo A]]
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[[Category: Gonzalez Bardeci N]]
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[[Category: Larrieux N]]
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[[Category: Trajtenberg F]]

Current revision

Crystal structure of the D/D domain of PKA from S. cerevisiae

PDB ID 6xqk

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