1n0x

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(New page: 200px<br /> <applet load="1n0x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1n0x, resolution 1.8&Aring;" /> '''Crystal Structure of...)
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[[Image:1n0x.gif|left|200px]]<br />
 
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<applet load="1n0x" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1n0x, resolution 1.8&Aring;" />
 
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'''Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope'''<br />
 
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==About this Structure==
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==Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope==
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1N0X is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4, K, CXS and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1N0X OCA].
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<StructureSection load='1n0x' size='340' side='right'caption='[[1n0x]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[1n0x]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1N0X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1N0X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CXS:3-CYCLOHEXYL-1-PROPYLSULFONIC+ACID'>CXS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1n0x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n0x OCA], [https://pdbe.org/1n0x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1n0x RCSB], [https://www.ebi.ac.uk/pdbsum/1n0x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1n0x ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN] Defects in IGKC are the cause of immunoglobulin kappa light chain deficiency (IGKCD) [MIM:[https://omim.org/entry/614102 614102]. IGKCD is a disease characterized by the complete absence of immunoglobulin kappa chains.<ref>PMID:3931219</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/IGKC_HUMAN IGKC_HUMAN]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n0/1n0x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1n0x ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Burton, D.R.]]
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[[Category: Synthetic construct]]
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[[Category: Irving, M.B.]]
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[[Category: Burton DR]]
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[[Category: Menendez, A.]]
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[[Category: Irving MB]]
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[[Category: Montero, M.]]
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[[Category: Menendez A]]
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[[Category: Parren, P.W.H.I.]]
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[[Category: Montero M]]
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[[Category: Saphire, E.O.]]
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[[Category: Parren PWHI]]
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[[Category: Scott, J.K.]]
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[[Category: Saphire EO]]
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[[Category: Wilson, I.A.]]
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[[Category: Scott JK]]
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[[Category: Zwick, M.B.]]
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[[Category: Wilson IA]]
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[[Category: CXS]]
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[[Category: Zwick MB]]
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[[Category: GOL]]
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[[Category: K]]
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[[Category: SO4]]
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[[Category: antibody-peptide complex]]
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[[Category: peptide dimer]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Thu Nov 8 14:21:02 2007''
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Current revision

Crystal Structure of a Broadly Neutralizing Anti-HIV-1 Antibody in Complex with a Peptide Mimotope

PDB ID 1n0x

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