7jsi
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Adeno-Associated Virus 2 Rep68 HD Hexamer-ssDNA with ATPgS== | |
| - | + | <StructureSection load='7jsi' size='340' side='right'caption='[[7jsi]], [[Resolution|resolution]] 5.01Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7jsi]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_2 Adeno-associated virus 2] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JSI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JSI FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.01Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jsi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jsi OCA], [https://pdbe.org/7jsi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jsi RCSB], [https://www.ebi.ac.uk/pdbsum/7jsi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jsi ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/REP68_AAV2S REP68_AAV2S] Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factor in site-specific integration of the viral genome. Inhibits the host cell cycle G1/S and G2/M transitions. These arrests may provide essential cellular factors for viral DNA replication.<ref>PMID:9882364</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Adeno-associated virus 2]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Escalante CR]] | ||
Current revision
Adeno-Associated Virus 2 Rep68 HD Hexamer-ssDNA with ATPgS
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