6ksw

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==Cryo-EM structure of the human concentrative nucleoside transporter CNT3==
==Cryo-EM structure of the human concentrative nucleoside transporter CNT3==
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<StructureSection load='6ksw' size='340' side='right'caption='[[6ksw]]' scene=''>
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<StructureSection load='6ksw' size='340' side='right'caption='[[6ksw]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KSW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6KSW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6ksw]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6KSW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6KSW FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6ksw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ksw OCA], [http://pdbe.org/6ksw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6ksw RCSB], [http://www.ebi.ac.uk/pdbsum/6ksw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6ksw ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ksw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ksw OCA], [https://pdbe.org/6ksw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ksw RCSB], [https://www.ebi.ac.uk/pdbsum/6ksw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ksw ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/S28A3_HUMAN S28A3_HUMAN] Sodium-dependent, pyrimidine- and purine-selective (PubMed:11032837, PubMed:15861042, PubMed:16446384, PubMed:17140564, PubMed:21998139). Involved in the homeostasis of endogenous nucleosides (PubMed:11032837, PubMed:15861042). Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) (PubMed:11032837). Employs a 2:1 sodium/nucleoside ratio (PubMed:11032837). Transports uridine (PubMed:21795683). Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (PubMed:11032837, PubMed:17140564).<ref>PMID:11032837</ref> <ref>PMID:15861042</ref> <ref>PMID:16446384</ref> <ref>PMID:17140564</ref> <ref>PMID:21795683</ref> <ref>PMID:21998139</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Deng D]]
[[Category: Deng D]]

Current revision

Cryo-EM structure of the human concentrative nucleoside transporter CNT3

PDB ID 6ksw

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