1cgl

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[[Image:1cgl.gif|left|200px]]
 
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==Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor==
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The line below this paragraph, containing "STRUCTURE_1cgl", creates the "Structure Box" on the page.
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<StructureSection load='1cgl' size='340' side='right'caption='[[1cgl]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1cgl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CGL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CGL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0ED:N-[(1S)-3-{[(BENZYLOXY)CARBONYL]AMINO}-1-CARBOXYPROPYL]-L-LEUCYL-N-(2-MORPHOLIN-4-YLETHYL)-L-PHENYLALANINAMIDE'>0ED</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_1cgl| PDB=1cgl | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cgl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cgl OCA], [https://pdbe.org/1cgl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cgl RCSB], [https://www.ebi.ac.uk/pdbsum/1cgl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cgl ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP1_HUMAN MMP1_HUMAN] Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity.<ref>PMID:1645757</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cg/1cgl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cgl ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF THE CATALYTIC DOMAIN OF FIBROBLAST COLLAGENASE COMPLEXED WITH AN INHIBITOR'''
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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== References ==
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==Overview==
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<references/>
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Collagenase is a zinc-dependent endoproteinase and is a member of the matrix metalloproteinase (MMP) family of enzymes. The MMPs participate in connective tissue remodeling events and aberrant regulation has been associated with several pathologies. The 2.4 angstrom resolution structure of the inhibited enzyme revealed that, in addition to the catalytic zinc, there is a second zinc ion and a calcium ion which play a major role in stabilizing the tertiary structure of collagenase. Despite scant sequence homology, collagenase shares structural homology with two other endoproteinases, bacterial thermolysin and crayfish astacin. The detailed description of protein-inhibitor interactions present in the structure will aid in the design of compounds that selectively inhibit individual members of the MMP family. Such inhibitors will be useful in examining the function of MMPs in pathological processes.
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__TOC__
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</StructureSection>
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==About this Structure==
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1CGL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CGL OCA].
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==Reference==
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Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor., Lovejoy B, Cleasby A, Hassell AM, Longley K, Luther MA, Weigl D, McGeehan G, McElroy AB, Drewry D, Lambert MH, et al., Science. 1994 Jan 21;263(5145):375-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8278810 8278810]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Interstitial collagenase]]
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[[Category: Large Structures]]
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[[Category: Single protein]]
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[[Category: Cleasby A]]
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[[Category: Cleasby, A.]]
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[[Category: Drewry D]]
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[[Category: Drewry, D.]]
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[[Category: Hassell AM]]
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[[Category: Hassell, A M.]]
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[[Category: Jordan SR]]
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[[Category: Jordan, S R.]]
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[[Category: Lambert MH]]
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[[Category: Lambert, M H.]]
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[[Category: Longley K]]
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[[Category: Longley, K.]]
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[[Category: Lovejoy B]]
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[[Category: Lovejoy, B.]]
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[[Category: Luther MA]]
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[[Category: Luther, M A.]]
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[[Category: Mcelroy AB]]
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[[Category: Mcelroy, A B.]]
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[[Category: Mcgeehan G]]
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[[Category: Mcgeehan, G.]]
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[[Category: Weigl D]]
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[[Category: Weigl, D.]]
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[[Category: Metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:42:51 2008''
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Current revision

Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor

PDB ID 1cgl

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