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7jtl
From Proteopedia
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==Structure of SARS-CoV-2 ORF8 accessory protein== | ==Structure of SARS-CoV-2 ORF8 accessory protein== | ||
| - | <StructureSection load='7jtl' size='340' side='right'caption='[[7jtl]]' scene=''> | + | <StructureSection load='7jtl' size='340' side='right'caption='[[7jtl]], [[Resolution|resolution]] 2.04Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JTL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JTL FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7jtl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JTL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JTL FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jtl OCA], [http://pdbe.org/7jtl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jtl RCSB], [http://www.ebi.ac.uk/pdbsum/7jtl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jtl ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jtl OCA], [http://pdbe.org/7jtl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jtl RCSB], [http://www.ebi.ac.uk/pdbsum/7jtl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jtl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/NS8_SARS2 NS8_SARS2]] May play a role in host-virus interaction. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The molecular basis for the severity and rapid spread of the COVID-19 disease caused by SARS-CoV-2 is largely unknown. ORF8 is a rapidly evolving accessory protein that has been proposed to interfere with immune responses. The crystal structure of SARS-CoV-2 ORF8 was determined at 2.04 A resolution by x-ray crystallography. The structure reveals a ~60 residue core similar to SARS-CoV ORF7a with the addition of two dimerization interfaces unique to SARS-CoV-2 ORF8. A covalent disulfide-linked dimer is formed through an N-terminal sequence specific to SARS-CoV-2, while a separate non-covalent interface is formed by another SARS-CoV-2-specific sequence, 73 YIDI 76 . Together the presence of these interfaces shows how SARS-CoV-2 ORF8 can form unique large-scale assemblies not possible for SARS-CoV, potentially mediating unique immune suppression and evasion activities. | ||
| + | |||
| + | Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion.,Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH bioRxiv. 2020 Aug 27. doi: 10.1101/2020.08.27.270637. PMID:32869027<ref>PMID:32869027</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7jtl" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: 2019-ncov]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Allaire M]] | + | [[Category: Allaire, M]] |
| - | [[Category: Buffalo | + | [[Category: Buffalo, C Z]] |
| - | [[Category: Flower | + | [[Category: Flower, T G]] |
| - | [[Category: Hooy | + | [[Category: Hooy, R M]] |
| - | [[Category: Hurley | + | [[Category: Hurley, J H]] |
| - | [[Category: Ren X]] | + | [[Category: Ren, X]] |
| + | [[Category: Accessory protein]] | ||
| + | [[Category: Coronavirus]] | ||
| + | [[Category: Covid-19]] | ||
| + | [[Category: Host-factor restriction]] | ||
| + | [[Category: Immune evasion]] | ||
| + | [[Category: Mhc-i]] | ||
| + | [[Category: Open reading frame 8]] | ||
| + | [[Category: Rna virus]] | ||
| + | [[Category: Sars-cov-2]] | ||
| + | [[Category: Sars2]] | ||
| + | [[Category: Viral protein]] | ||
Current revision
Structure of SARS-CoV-2 ORF8 accessory protein
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