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5nfh

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Current revision (12:53, 15 November 2023) (edit) (undo)
 
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<StructureSection load='5nfh' size='340' side='right'caption='[[5nfh]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
<StructureSection load='5nfh' size='340' side='right'caption='[[5nfh]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5nfh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5NFH FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5nfh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei_TREU927 Trypanosoma brucei brucei TREU927]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5NFH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5NFH FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8W2:2-[3-[[4,6-bis(chloranyl)-1~{H}-indol-2-yl]methylamino]propylamino]-3~{H}-quinazolin-4-one'>8W2</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionine--tRNA_ligase Methionine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.10 6.1.1.10] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8W2:2-[3-[[4,6-bis(chloranyl)-1~{H}-indol-2-yl]methylamino]propylamino]-3~{H}-quinazolin-4-one'>8W2</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MET:METHIONINE'>MET</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5nfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfh OCA], [http://pdbe.org/5nfh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5nfh RCSB], [http://www.ebi.ac.uk/pdbsum/5nfh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfh ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5nfh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5nfh OCA], [https://pdbe.org/5nfh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5nfh RCSB], [https://www.ebi.ac.uk/pdbsum/5nfh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5nfh ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q38C91_TRYB2 Q38C91_TRYB2]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Methionine--tRNA ligase]]
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[[Category: Trypanosoma brucei brucei TREU927]]
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[[Category: Eadsforth, T C]]
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[[Category: De Rycker M]]
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[[Category: Gilbert, I H]]
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[[Category: Eadsforth TC]]
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[[Category: Robinson, D A]]
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[[Category: Gilbert IH]]
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[[Category: Rycker, M De]]
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[[Category: Robinson DA]]
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[[Category: Shepherd, S M]]
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[[Category: Shepherd SM]]
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[[Category: Torrie, L S]]
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[[Category: Torrie LS]]
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[[Category: Complex]]
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[[Category: Drug discovery]]
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[[Category: Inhibitor]]
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[[Category: Ligase]]
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[[Category: Ligase-ligase inhibitor]]
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[[Category: Methionine]]
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[[Category: Synthetase]]
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Current revision

Trypanosoma brucei methionyl-tRNA synthetase in complex with a quinazolinone inhibitor

PDB ID 5nfh

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