5oen

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Current revision (16:46, 13 December 2023) (edit) (undo)
 
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<StructureSection load='5oen' size='340' side='right'caption='[[5oen]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
<StructureSection load='5oen' size='340' side='right'caption='[[5oen]], [[Resolution|resolution]] 2.92&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5oen]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5OEN FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5oen]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5OEN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5OEN FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5oen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oen OCA], [http://pdbe.org/5oen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5oen RCSB], [http://www.ebi.ac.uk/pdbsum/5oen PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5oen ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.919&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5oen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5oen OCA], [https://pdbe.org/5oen PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5oen RCSB], [https://www.ebi.ac.uk/pdbsum/5oen PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5oen ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IRF9_MOUSE IRF9_MOUSE]] Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
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[https://www.uniprot.org/uniprot/IRF9_MOUSE IRF9_MOUSE] Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1:STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Panne, D]]
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[[Category: Mus musculus]]
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[[Category: Rengachari, S]]
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[[Category: Panne D]]
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[[Category: Irf9]]
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[[Category: Rengachari S]]
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[[Category: Stat2]]
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[[Category: Transcription]]
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Current revision

Crystal Structure of STAT2 in complex with IRF9

PDB ID 5oen

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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