7cv3
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Quadruplex-duplex hybrid structure in the PIM1 gene, Form 1== | |
| + | <StructureSection load='7cv3' size='340' side='right'caption='[[7cv3]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7cv3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CV3 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cv3 OCA], [https://pdbe.org/7cv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cv3 RCSB], [https://www.ebi.ac.uk/pdbsum/7cv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cv3 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The triple-negative breast cancer (TNBC), a subtype of breast cancer which lacks of targeted therapies, exhibits a poor prognosis. It was shown recently that the PIM1 oncogene is highly related to the proliferation of TNBC cells. A quadruplex-duplex hybrid (QDH) forming sequence was recently found to exist near the transcription start site of PIM1. This structure could be an attractive target for regulation of the PIM1 gene expression and thus the treatment of TNBC. Here, we present the solution structures of two QDHs that could coexist in the human PIM1 gene. Form 1 is a three-G-tetrad-layered (3+1) G-quadruplex containing a propeller loop, a lateral loop and a stem-loop made up of three G*C Watson-Crick base pairs. On the other hand, Form 2 is an anti-parallel G-quadruplex comprising two G-tetrads and a G*C*G*C tetrad; the structure has three lateral loops with the middle stem-loop made up of two Watson-Crick G*C base pairs. These structures provide valuable information for the design of G-quadruplex-specific ligands for PIM1 transcription regulation. | ||
| - | + | Coexistence of two quadruplex-duplex hybrids in the PIM1 gene.,Tan DJY, Winnerdy FR, Lim KW, Phan AT Nucleic Acids Res. 2020 Sep 25. pii: 5911740. doi: 10.1093/nar/gkaa752. PMID:32976598<ref>PMID:32976598</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Lim | + | <div class="pdbe-citations 7cv3" style="background-color:#fffaf0;"></div> |
| - | [[Category: Phan | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Lim KW]] | ||
| + | [[Category: Phan AT]] | ||
| + | [[Category: Tan DJY]] | ||
| + | [[Category: Winnerdy FR]] | ||
Current revision
Quadruplex-duplex hybrid structure in the PIM1 gene, Form 1
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