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6xjl

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Current revision (14:50, 6 March 2024) (edit) (undo)
 
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<StructureSection load='6xjl' size='340' side='right'caption='[[6xjl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='6xjl' size='340' side='right'caption='[[6xjl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6xjl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XJL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6XJL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6xjl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XJL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XJL FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6xm1|6xm1]], [[6xmd|6xmd]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6xjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xjl OCA], [http://pdbe.org/6xjl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6xjl RCSB], [http://www.ebi.ac.uk/pdbsum/6xjl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6xjl ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xjl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xjl OCA], [https://pdbe.org/6xjl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xjl RCSB], [https://www.ebi.ac.uk/pdbsum/6xjl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xjl ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/G0S539_CHATD G0S539_CHATD]
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Fusion of intracellular trafficking vesicles is mediated by the assembly of SNARE proteins into membrane-bridging complexes. SNARE-mediated membrane fusion requires Sec1/Munc18-family (SM) proteins, SNARE chaperones that can function as templates to catalyze SNARE complex assembly. Paradoxically, the SM protein Munc18-1 traps the Qa-SNARE protein syntaxin-1 in an autoinhibited closed conformation. Here we present the structure of a second SM-Qa-SNARE complex, Vps45-Tlg2. Strikingly, Vps45 holds Tlg2 in an open conformation, with its SNARE motif disengaged from its Habc domain and its linker region unfolded. The domain 3a helical hairpin of Vps45 is unfurled, exposing the presumptive R-SNARE binding site to allow template complex formation. Although Tlg2 has a pronounced tendency to form homo-tetramers, Vps45 can rescue Tlg2 tetramers into stoichiometric Vps45-Tlg2 complexes. Our findings demonstrate that SM proteins can engage Qa-SNAREs using at least two different modes, one in which the SNARE is closed and one in which it is open.
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The Sec1/Munc18 protein Vps45 holds the Qa-SNARE Tlg2 in an open conformation.,Eisemann TJ, Allen F, Lau K, Shimamura GR, Jeffrey PD, Hughson FM Elife. 2020 Aug 17;9. pii: 60724. doi: 10.7554/eLife.60724. PMID:32804076<ref>PMID:32804076</ref>
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==See Also==
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*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6xjl" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cbs 144 50]]
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[[Category: Chaetomium thermophilum]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Allen, F]]
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[[Category: Allen F]]
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[[Category: Hughson, F M]]
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[[Category: Hughson FM]]
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[[Category: Jeffrey, P D]]
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[[Category: Jeffrey PD]]
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[[Category: Shimamura, G S]]
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[[Category: Shimamura GS]]
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[[Category: Membrane trafficking]]
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[[Category: Sm protein]]
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[[Category: Thermophile]]
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[[Category: Transport protein]]
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Current revision

Structure of the SM protein Vps45

PDB ID 6xjl

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