MDM2 3D structures
From Proteopedia
(Difference between revisions)
| (2 intermediate revisions not shown.) | |||
| Line 6: | Line 6: | ||
*'''MDM2''' ); Domains – p53-binding 24-220; ring – 383-446; C4 zinc-finger 429-491 | *'''MDM2''' ); Domains – p53-binding 24-220; ring – 383-446; C4 zinc-finger 429-491 | ||
| - | **[[2ruh]] - hMDM2 p53-binding domain | + | **[[8bgu]] - hMDM2 + RNA - human<br /> |
| + | **[[2ruh]] - hMDM2 p53-binding domain <br /> | ||
**[[1z1m]] – hMDM2 p53-binding domain - NMR<br /> | **[[1z1m]] – hMDM2 p53-binding domain - NMR<br /> | ||
**[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain - NMR<br /> | **[[2c6a]], [[2c6b]] – hMDM2 C4 Zinc-finger domain - NMR<br /> | ||
| Line 12: | Line 13: | ||
**[[6sqp]] - cMDM2 C4 ring-finger domain – cat<br /> | **[[6sqp]] - cMDM2 C4 ring-finger domain – cat<br /> | ||
**[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br /> | **[[4ipf]], [[4j74]] – fMDM2 p53-binding domain (mutant) - frog<br /> | ||
| + | **[[7ahy]] - fMDM2 RING domain <br /> | ||
| + | **[[7ah2]] - MDM2 RING domain – zebrafish<br /> | ||
*MDM2 p53-binding domain complex with small molecule | *MDM2 p53-binding domain complex with small molecule | ||
**[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br /> | **[[1rv1]], [[1t4e]], [[3lbk]], [[4dij]], [[3vzv]], [[3w69]], [[3lkb]], [[4lwt]], [[4lwu]], [[4lwv]], [[4oq3]], [[5hmh]], [[5hmi]], [[5hmk]] – hMDM2 (mutant) + inhibitor<br /> | ||
| - | **[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]] - hMDM2 + inhibitor<br /> | + | **[[3jzk]], [[3lbl]], [[3tu1]], [[4ere]], [[4erf]], [[3tj2]], [[4hbm]], [[4jv7]], [[4jv9]], [[4jve]], [[4jvr]], [[4jwr]], [[4mdn]], [[4mdq]], [[4oas]], [[4oba]], [[4occ]], [[4ode]], [[4odf]], [[4ogn]], [[4ogt]], [[4ogv]], [[4qo4]], [[4hg7]], [[4wt2]], [[4qoc]], [[4wt2]], [[4zfi]], [[4zgk]], [[4zyf]], [[4zyi]], [[5j7f]], [[5j7g]], [[5lav]], [[5law]], [[5lay]], [[5laz]], [[5ln2]], [[5trf]], [[6q96]], [[6q9h]], [[6q9l]], [[6q9o]], [[6i3s]], [[6ggn]], [[5oc8]], [[5oai]], [[6i29]], [[7bir]], [[7bit]], [[7biv]], [[7bj0]], [[7bj6]], [[7bmg]], [[7na1]], [[7na2]], [[7na3]], [[7na4]], [[7qdq]], [[8aeu]] - hMDM2 + inhibitor<br /> |
**[[5z02]], [[5zxf]] - hMDM2 + nutlin<br /> | **[[5z02]], [[5zxf]] - hMDM2 + nutlin<br /> | ||
**[[2lzg]] - hMDM2 + inhibitor – NMR<br /> | **[[2lzg]] - hMDM2 + inhibitor – NMR<br /> | ||
| Line 27: | Line 30: | ||
**[[1t4f]], [[4hfz]] - hMDM2 (mutant) p53-binding domain + p53 peptide<br /> | **[[1t4f]], [[4hfz]] - hMDM2 (mutant) p53-binding domain + p53 peptide<br /> | ||
| - | **[[3v3b]] - hMDM2 p53-binding domain + p53 peptide<br /> | + | **[[3v3b]], [[7ad0]], [[7nus]] - hMDM2 p53-binding domain + p53 peptide<br /> |
**[[2mps]] - hMDM2 p53-binding domain + p73 peptide<br /> | **[[2mps]] - hMDM2 p53-binding domain + p73 peptide<br /> | ||
**[[3jzr]] - hMDM2 p53-binding domain + pDI6W peptide<br /> | **[[3jzr]] - hMDM2 p53-binding domain + pDI6W peptide<br /> | ||
| Line 33: | Line 36: | ||
**[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br /> | **[[3jzs]] - hMDM2 p53-binding domain + pDIQ peptide<br /> | ||
**[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br /> | **[[3tpx]] - hMDM2 p53-binding domain + D-peptide inhibitor<br /> | ||
| - | **[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], ]] | + | **[[2axi]], [[2gv2]], [[3eqs]], [[3g03]], [[3iux]], [[3lnj]], [[3lnz]], [[3iwy]], [[5umm]], [[6hfa]], [[7kjm]], [[8f0z]], [[8f10]], [[8f12]], [[8f13]] - hMDM2 p53-binding domain + peptide inhibitor<br /> |
**[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br /> | **[[5vk0]], [[6kzu]], [[6aaw]] - hMDM2 p53-binding domain + stapled peptide<br /> | ||
**[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br /> | **[[4ud7]], [[4ue1]], [[4umn]], [[5afg]], [[5xxk]], [[6h22]], [[6t2d]], [[6t2e]], [[6t2f]], [[6y4q]] - hMDM2 p53-binding domain (mutant) + stapled peptide<br /> | ||
| Line 46: | Line 49: | ||
**[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br /> | **[[5swk]] - hMDM2 p53-binding domain + cysteine protease inhibitor<br /> | ||
**[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br /> | **[[6im9]] - hMDM2 p53-binding domain + copper reflux oxidase<br /> | ||
| + | **[[7aye]] - hMDM2 p53-binding domain + DsbD<br /> | ||
**[[6sqo]] - hMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br /> | **[[6sqo]] - hMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br /> | ||
**[[6sqr]], [[6sqs]] - cMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br /> | **[[6sqr]], [[6sqs]] - cMDM2 ring domain + ubiquitin-conjugating enzyme E2 + S27A<br /> | ||
| + | **[[7ahz]], [[7ai0]], [[7ai1]] - fMDM2 RING domain (mutant) + polyubiquitin + ubiquitin-conjugating enzyme E2<br /> | ||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D structures of MDM2
Updated on 27-June-2023
