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6zj4

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'''Unreleased structure'''
 
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The entry 6zj4 is ON HOLD until Paper Publication
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==apo-Trehalose transferase (apo-TreT) from Thermoproteus uzoniensis==
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<StructureSection load='6zj4' size='340' side='right'caption='[[6zj4]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[6zj4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermoproteus_uzoniensis Thermoproteus uzoniensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZJ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZJ4 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zj4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zj4 OCA], [https://pdbe.org/6zj4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zj4 RCSB], [https://www.ebi.ac.uk/pdbsum/6zj4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zj4 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/F2L613_THEU7 F2L613_THEU7]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Retaining LeLoir glycosyltransferases catalyze the formation of glycosidic bonds between nucleotide sugar donors and carbohydrate acceptors. The anomeric selectivity of trehalose transferase from Thermoproteus uzoniensis was investigated for both d- and l-glycopyranose acceptors. The enzyme couples a wide range of carbohydrates, yielding trehalose analogues with conversion and enantioselectivity of &gt;98%. The anomeric selectivity inverts from alpha,alpha-(1 --&gt; 1)-glycosidic bonds for d-glycopyranose acceptors to alpha,beta-(1 --&gt; 1)-glycosidic bonds for l-glycopyranose acceptors, while (S)-selectivity was retained for both types of sugar acceptors. Comparison of protein crystal structures of trehalose transferase in complex with alpha,alpha-trehalose and an unnatural alpha,beta-trehalose analogue highlighted the mechanistic rationale for the observed inversion of anomeric selectivity.
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Authors: Bento, I., Mestrom, L., Marsden, S.R., van der Eijk, H., Laustsen, J.U., Jeffries, C.M., Svergun, D.I., Hagedoorn, P.-H., Hanefeld, U.
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Anomeric Selectivity of Trehalose Transferase with Rare l-Sugars.,Mestrom L, Marsden SR, van der Eijk H, Laustsen JU, Jeffries CM, Svergun DI, Hagedoorn PL, Bento I, Hanefeld U ACS Catal. 2020 Aug 7;10(15):8835-8839. doi: 10.1021/acscatal.0c02117. Epub 2020 , Jul 22. PMID:32953231<ref>PMID:32953231</ref>
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Description: apo-Trehalose transferase (apo-TreT) from Thermoproteus uzoniensis
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Bento, I]]
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<div class="pdbe-citations 6zj4" style="background-color:#fffaf0;"></div>
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[[Category: Mestrom, L]]
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== References ==
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[[Category: Hanefeld, U]]
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<references/>
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[[Category: Marsden, S.R]]
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__TOC__
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[[Category: Svergun, D.I]]
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</StructureSection>
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[[Category: Laustsen, J.U]]
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[[Category: Large Structures]]
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[[Category: Hagedoorn, P.-H]]
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[[Category: Thermoproteus uzoniensis]]
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[[Category: Jeffries, C.M]]
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[[Category: Bento I]]
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[[Category: Van Der Eijk, H]]
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[[Category: Hagedoorn P-H]]
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[[Category: Hanefeld U]]
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[[Category: Jeffries CM]]
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[[Category: Laustsen JU]]
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[[Category: Marsden SR]]
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[[Category: Mestrom L]]
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[[Category: Svergun DI]]
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[[Category: Van der Eijk H]]

Current revision

apo-Trehalose transferase (apo-TreT) from Thermoproteus uzoniensis

PDB ID 6zj4

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