6zhi
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| - | ==== | + | ==Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide== |
| - | <StructureSection load='6zhi' size='340' side='right'caption='[[6zhi]]' scene=''> | + | <StructureSection load='6zhi' size='340' side='right'caption='[[6zhi]], [[Resolution|resolution]] 3.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6zhi]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum] and [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZHI FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.25Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zhi OCA], [https://pdbe.org/6zhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zhi RCSB], [https://www.ebi.ac.uk/pdbsum/6zhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zhi ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/K7NTP5_PLAF7 K7NTP5_PLAF7] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The malaria parasite Plasmodium falciparum extensively modifies erythrocytes that it invades by exporting a large complement of proteins to the host cell. Among these exported components is a single heat-shock 70 kDa class protein, PfHsp70-x, that supports the virulence and growth rate of the parasite during febrile episodes. The ATP-binding domain of PfHsp70-x has previously been resolved and showed the presence of potentially druggable epitopes that differ from those on human Hsp70 chaperones. Here, the crystallographic structure of the substrate-binding domain (SBD) of PfHsp70-x is presented in complex with a hydrophobic peptide. The PfHsp70-x SBD is shown to be highly similar to the counterpart from a human erythrocytic Hsp70 chaperone. The binding of substrate at the interface between beta-sandwich and alpha-helical subdomains of this chaperone segment is also conserved between the malaria parasite and humans. It is hypothesized that the parasite may partly exploit human chaperones for intra-erythrocytic trafficking and maintenance of its exported proteome. | ||
| + | |||
| + | Structure of the substrate-binding domain of Plasmodium falciparum heat-shock protein 70-x.,Schmidt J, Vakonakis I Acta Crystallogr F Struct Biol Commun. 2020 Oct 1;76(Pt 10):495-500. doi: , 10.1107/S2053230X2001208X. Epub 2020 Sep 28. PMID:33006578<ref>PMID:33006578</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6zhi" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Plasmodium falciparum]] |
| + | [[Category: Plasmodium falciparum 3D7]] | ||
| + | [[Category: Schmidt J]] | ||
| + | [[Category: Vakonakis I]] | ||
Current revision
Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide
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