3fnl

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<StructureSection load='3fnl' size='340' side='right'caption='[[3fnl]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
<StructureSection load='3fnl' size='340' side='right'caption='[[3fnl]], [[Resolution|resolution]] 2.48&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3fnl]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FNL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=3FNL FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3fnl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bubalus_bubalis Bubalus bubalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3FNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3FNL FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SHA:SALICYLHYDROXAMIC+ACID'>SHA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.48&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=SHA:SALICYLHYDROXAMIC+ACID'>SHA</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2z5z|2z5z]], [[2o86|2o86]], [[2gjm|2gjm]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fnl OCA], [https://pdbe.org/3fnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3fnl RCSB], [https://www.ebi.ac.uk/pdbsum/3fnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3fnl ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxidase Peroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.7 1.11.1.7] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=3fnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3fnl OCA], [http://pdbe.org/3fnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3fnl RCSB], [http://www.ebi.ac.uk/pdbsum/3fnl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3fnl ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PERL_BUBBU PERL_BUBBU] Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN). May protect the udder from infection and promote growth in newborn calves. Inhibits growth of the following bacterial species: E.coli, K.pneumoniae, P.aeruginosa, S.sonnei, S.saphrophyticus, S.epidermidis, and S.dysenteriae.<ref>PMID:12071645</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<jmolCheckbox>
<jmolCheckbox>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/3fnl_consurf.spt"</scriptWhenChecked>
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fn/3fnl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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==See Also==
==See Also==
*[[Lactoperoxidase|Lactoperoxidase]]
*[[Lactoperoxidase|Lactoperoxidase]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bubalus bubalis]]
[[Category: Bubalus bubalis]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Peroxidase]]
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[[Category: Bhushan A]]
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[[Category: Bhushan, A]]
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[[Category: Kaur P]]
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[[Category: Kaur, P]]
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[[Category: Sharma S]]
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[[Category: Sharma, S]]
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[[Category: Sheikh IA]]
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[[Category: Sheikh, I A]]
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[[Category: Singh N]]
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[[Category: Singh, N]]
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[[Category: Singh TP]]
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[[Category: Singh, T P]]
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[[Category: Sinha M]]
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[[Category: Sinha, M]]
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[[Category: Vikram G]]
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[[Category: Vikram, G]]
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[[Category: Buffalo]]
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[[Category: Lactoperoxidase]]
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[[Category: Oxidoreductase]]
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[[Category: Salicylhydroxamic acid]]
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Current revision

Crystal Structure of the Complex of Buffalo Lactoperoxidase with Salicylhydroxamic Acid at 2.48 A Resolution

PDB ID 3fnl

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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