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Neuraminidase 3D structures

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Current revision (08:02, 13 July 2023) (edit) (undo)
 
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Line 11: Line 11:
**[[3h71]] - SpNANA catalytic domain precursor<br />
**[[3h71]] - SpNANA catalytic domain precursor<br />
**[[4zxk]] - SpNANA carbohydrate-binding domain<br />
**[[4zxk]] - SpNANA carbohydrate-binding domain<br />
-
**[[2vw0]], [[2vw1]], [[2vw2]] – SpNANB<br />
 
-
**[[4xmi]], [[4xma]], [[4xjz]], [[4xj8]], [[4xio]], [[4xik]] – SpNANB (mutant)<br />
 
**[[4yz4]], [[4yw4]] – SpNANC<br />
**[[4yz4]], [[4yw4]] – SpNANC<br />
**[[2xzi]], [[2xzj]], [[2xzk]], [[2xcy]] – NANA – ''Aspergillus fumigatus''<br />
**[[2xzi]], [[2xzj]], [[2xzk]], [[2xcy]] – NANA – ''Aspergillus fumigatus''<br />
Line 20: Line 18:
**[[1euu]] - MvNANA residues 47-647 <br />
**[[1euu]] - MvNANA residues 47-647 <br />
**[[1wcq]], [[1w8n]], [[1w8o]], [[2hu0]], [[2hu4]] – MvNANA residues 47-647 (mutant) <br />
**[[1wcq]], [[1w8n]], [[1w8o]], [[2hu0]], [[2hu4]] – MvNANA residues 47-647 (mutant) <br />
-
**[[3sil]] – StNANA (mutant) – ''Salmonella typhimurium''<br />
+
**[[3sil]], [[6trg]], [[7af2]] – StNANA (mutant) – ''Salmonella typhimurium''<br />
**[[4bbw]], [[5muk]] – BtNAN – ''Bacterioides thetaiotaomicron''<br />
**[[4bbw]], [[5muk]] – BtNAN – ''Bacterioides thetaiotaomicron''<br />
**[[5tsp]] - NANI + CHES – ''Clostridium perfringens''<br />
**[[5tsp]] - NANI + CHES – ''Clostridium perfringens''<br />
 +
**[[6mrx]] - baNANA - bacterium<br />
*Binary complexes
*Binary complexes
Line 34: Line 33:
**[[2ya7]], [[2ya8]], [[5kky]], [[5f9t]] - SpNANA catalytic domain + inhibitor<br />
**[[2ya7]], [[2ya8]], [[5kky]], [[5f9t]] - SpNANA catalytic domain + inhibitor<br />
**[[2ya6]]- SpNANA catalytic domain + sialic acid analog<br />
**[[2ya6]]- SpNANA catalytic domain + sialic acid analog<br />
-
**[[2jkb]] - SpNANB residues 30-697 + sialic acid analog<br />
 
-
**[[4c1w]] - SpNANB residues 52-236 + sialic acid derivative<br />
 
-
**[[4foq]] [[4fov]], [[4fow]], [[4foy]], [[4fp2]], [[4fp3]], [[4fpc]], [[4fpe]], [[4fpf]], [[4fpg]], [[4fph]], [[4fpj]], [[4fpk]], [[4fpl]], [[4fpo]], [[4fpy]], [[4fq4]] – SpNANB + inhibitor<br />
 
-
**[[4xyx]] – SpNANB + drug<br />
 
-
**[[4yw2]] – SpNANB residues 83-740 + sialic acid<br />
 
-
**[[4xog]], [[4xjw]], [[4xj9]], [[4xil]], [[4xe9]] – SpNANB (mutant) + drug<br />
 
-
**[[4xju]], [[4xja]], [[4xhx]], [[4xhb]] – SpNANB (mutant) + inhibitor<br />
 
**[[4yz2]], [[4yw3]], [[4wy2]], [[4wy1]] – SpNANC + inhibitor<br />
**[[4yz2]], [[4yw3]], [[4wy2]], [[4wy1]] – SpNANC + inhibitor<br />
**[[4yw1]] – SpNANC residues 83-740 + sialic acid + neuraminic acid derivative <br />
**[[4yw1]] – SpNANC residues 83-740 + sialic acid + neuraminic acid derivative <br />
Line 51: Line 43:
**[[2ber]] - MvNANA residues 47-647 (mutant) + sialic derivative<br />
**[[2ber]] - MvNANA residues 47-647 (mutant) + sialic derivative<br />
**[[1dil]], [[1dim]] – StNANA + inhibitor<br />
**[[1dil]], [[1dim]] – StNANA + inhibitor<br />
-
**[[2sim]], [[2sil]] - StNANA + neuraminic acid derivative<br />
+
**[[2sim]], [[2sil]], [[7aey]] - StNANA + neuraminic acid derivative<br />
 +
**[[6tvi]] - StNANA (mutant) + neuraminic acid derivative<br />
**[[5mul]] – BtNAN + glucuronic acid<br />
**[[5mul]] – BtNAN + glucuronic acid<br />
-
 
+
**[[6myv]] - baNANA + neuraminic acid derivative <br />
*'''Influenza virus neuraminidase'''
*'''Influenza virus neuraminidase'''
Line 60: Line 53:
**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
**[[4fvk]], [[4gez]] - IvNANA residues 76-442<br />
**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
**[[3k38]], [[4hzy]] – IvNANA (mutant) <br />
-
**[[4b7m]], [[6d96]] - IvNAN H1n1<br />
+
**[[4b7m]], [[6d96]], [[7s0i]] - IvNAN H1n1<br />
-
**[[6n4d]] – IvNAN H3n2<br />
+
**[[7u2q]], [[7u2t]] - IvNAN – Cryo EM<br />
 +
**[[4cpl]], [[4cpn]], [[4cpo]] - IvNAN <br />
 +
**[[6n4d]], [[7u4e]], [[7u4f]], [[7u4g]] – IvNAN H3n2<br />
**[[4qn4]] – IvNAN H3n6<br />
**[[4qn4]] – IvNAN H3n6<br />
**[[4wa3]] – IvNAN H3n8<br />
**[[4wa3]] – IvNAN H3n8<br />
Line 81: Line 76:
**[[2ht5]] – IvNAN N8 residues 82-469<br />
**[[2ht5]] – IvNAN N8 residues 82-469<br />
**[[6hfc]], [[6d3b]] – IvNAN N9<br />
**[[6hfc]], [[6d3b]] – IvNAN N9<br />
 +
**[[7nn9]] - IvNAN N9 Tern <br />
**[[2qwa]] - IvNAN N9 Tern (mutant)<br />
**[[2qwa]] - IvNAN N9 Tern (mutant)<br />
 +
**[[6crd]] - IvNAN N9 Tern/tetrabrachion <br />
 +
**[[7cm1]], [[7fgb]], [[7fgc]], [[7fgd]], [[7fge]] - IvNAN - toad<br />
 +
**[[7xvr]], [[7xvu]], [[7xvv]], [[7xvw]] - IvNAN - eel<br />
*Binary complexes of Influenza virus neuraminidase
*Binary complexes of Influenza virus neuraminidase
Line 90: Line 89:
**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
**[[1f8b]], [[1inv]], [[1inw]], [[1inx]], [[1iny]], [[4gb1]] – IvNANA + sialic acid analog<br />
**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]], [[6g02]], [[6g01]] - IvNAN H1n1 + inhibitor<br />
**[[3ti3]], [[3ti4]], [[3ti5]], [[3ti6]], [[6g02]], [[6g01]] - IvNAN H1n1 + inhibitor<br />
-
**[[4qnp]], [[6q23]] - IvNAN H1n1 + antibody<br />
+
**[[4qnp]], [[6q23]], [[6lxi]], [[6lxk]] - IvNAN H1n1 + antibody<br />
 +
**[[8g30]], [[8g3m]], [[8g3n]], [[8g3o]], [[8g3p]], [[8g3q]], [[8g3r]], [[8g3v]], [[8g3z]], [[8g40]] - IvNAN + antibody – Cryo EM<br />
**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
**[[3tia]], [[3tib]], [[3tic]] – IvNAN H2n2 + inhibitor<br />
**[[6q20]] - IvNAN H2n2 + antibody<br />
**[[6q20]] - IvNAN H2n2 + antibody<br />
**[[6n6b]] - IvNAN H3n2 + antibody<br />
**[[6n6b]] - IvNAN H3n2 + antibody<br />
-
**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]] – IvNAN H3n2 + sialic acid<br />
+
**[[2bat]], [[4gzw]], [[4gzx]], [[4gzq]], [[8dwb]] – IvNAN H3n2 + sialic acid<br />
**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN H5n1 + inhibitor<br />
**[[2ht7]], [[2ht8]], [[2htq]], [[2htu]] – IvNAN H5n1 + inhibitor<br />
**[[2htr]], [[2htw]] – IvNAN H5n1 + sialic acid analog<br /
**[[2htr]], [[2htw]] – IvNAN H5n1 + sialic acid analog<br /
**[[5l18]] - IvNAN H7n9 + sialic acid<br />
**[[5l18]] - IvNAN H7n9 + sialic acid<br />
-
**[[6q1z]], [[6pzf]], [[6pzw]], [[6pzy]], [[6pzz]] - IvNAN H7n9 + antibody<br />
+
**[[6lxj]], [[6q1z]], [[6pzf]], [[6pzw]], [[6pzy]], [[6pzz]] - IvNAN H7n9 + antibody<br />
**[[6u02]] - IvNAN H7n9 + antibody – Cryo EM<br />
**[[6u02]] - IvNAN H7n9 + antibody – Cryo EM<br />
**[[6pze]] - IvNAN H7n9 (mutant) + antibody<br />
**[[6pze]] - IvNAN H7n9 (mutant) + antibody<br />
 +
**[[6v4n]], [[6v4o]] - IvNAN + antibody – Cryo EM<br />
**[[1nna]], [[1nnb]], [[5w2y]], [[5w2w]], [[5w2u]], [[5w26]] - IvNAN H11n9 + neuraminic acid derivative<br />
**[[1nna]], [[1nnb]], [[5w2y]], [[5w2w]], [[5w2u]], [[5w26]] - IvNAN H11n9 + neuraminic acid derivative<br />
**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br />
**[[4dgr]] - IvNAN H11n9 + benzoic acid derivative<br />
Line 116: Line 117:
*Binary complexes of Influenza virus neuraminidase with drugs
*Binary complexes of Influenza virus neuraminidase with drugs
-
**[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]], [[5nzn]], [[6hp0]] - IvNAN H1n1 + drug<br />
+
**[[4b7j]], [[4b7n]], [[4b7q]], [[4b7r]], [[4cpm]], [[4cpy]], [[4cpz]],[[5nzn]], [[6hp0]] - IvNAN H1n1 + drug<br />
**[[5nzf]], [[5nze]], [[5nz4]], [[5nwe]] - IvNAN H1n1 (mutant) + drug<br />
**[[5nzf]], [[5nze]], [[5nz4]], [[5nwe]] - IvNAN H1n1 (mutant) + drug<br />
**[[4gzp]], [[4gzt]], [[6br6]], [[6br5]] - IvNAN H3n2 + drug<br />
**[[4gzp]], [[4gzt]], [[6br6]], [[6br5]] - IvNAN H3n2 + drug<br />
Line 124: Line 125:
**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + flu drug<br />
**[[4mwq]], [[4mwr]], [[4mwu]], [[4mwv]], [[4mww]], [[4mwx]], [[4mwy]], [[4mx0]] - IvNAN H7n9 + flu drug<br />
**[[4qn7]]- IvNAN H10n7 + drug<br />
**[[4qn7]]- IvNAN H10n7 + drug<br />
-
**[[3san]], [[3ti8]] - IvNAN H12N5 + flu drug<br />
+
**[[3san]], [[3ti8]], [[7e6q]] - IvNAN H12N5 + flu drug<br />
**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
**[[4hzw]], [[4hzx]] - IvNAN N3 + flu drug<br />
**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
**[[4hzz]], [[4i00]] - IvNAN N3 (mutant) + flu drug<br />
**[[6hg5]] - IvNAN N6 + flu drug<br />
**[[6hg5]] - IvNAN N6 + flu drug<br />
-
**[[6hfy]] - IvNAN N6 + DANA<br />
+
**[[6hfy]] - IvNAN N6 + neuraminic acid derivative<br />
**[[6heb]], [[6hcx]] - IvNAN N9 + flu drug<br />
**[[6heb]], [[6hcx]] - IvNAN N9 + flu drug<br />
**[[6hg0]] - IvNAN N9 Tern + NANA<br />
**[[6hg0]] - IvNAN N9 Tern + NANA<br />
Line 146: Line 147:
**[[2sli]], [[1sli]], [[3sli]] – lTS + inhibitor – leech<br />
**[[2sli]], [[1sli]], [[3sli]] – lTS + inhibitor – leech<br />
**[[1mr5]], [[1ms3]], [[1ms4]] - TcTS (mutant) – ''Trypanosoma cruzi''<br />
**[[1mr5]], [[1ms3]], [[1ms4]] - TcTS (mutant) – ''Trypanosoma cruzi''<br />
-
**[[1ms0]] - TcTS (mutant) + DANA + lactose<br />
+
**[[1ms0]] - TcTS (mutant) + neuraminic acid derivative + lactose<br />
-
**[[1ms1]], [[1ms8]] - TcTS (mutant) + DANA <br />
+
**[[1ms1]], [[1ms8]] - TcTS (mutant) + neuraminic acid derivative <br />
**[[3b69]] - TcTS (mutant) + NANA derivative<br />
**[[3b69]] - TcTS (mutant) + NANA derivative<br />
**[[1ms5]] - TcTS (mutant) + Na-S-Gal<br />
**[[1ms5]] - TcTS (mutant) + Na-S-Gal<br />
Line 155: Line 156:
**[[3opz]] - TcTS (mutant) + antibody<br />
**[[3opz]] - TcTS (mutant) + antibody<br />
**[[2ah2]] - TcTS (mutant) + difluorosialic acid<br />
**[[2ah2]] - TcTS (mutant) + difluorosialic acid<br />
 +
 +
*'''Neuraminidase B or sialidase B'''
 +
 +
**[[2vw0]], [[2vw1]], [[2vw2]] – SpNANB<br />
 +
**[[4xhb]], [[4xik]], [[4xio]], [[4xjz]], [[4xmi]] - SpNANB (mutant) <br />
 +
**[[4foq]], [[4fov]], [[4fow]], [[4foy]], [[4fp2]], [[4fp3]], [[4fpc]], [[4fpe]], [[4fpf]], [[4fpg]], [[4fph]], [[4fpj]], [[4fpk]], [[4fpl]], [[4fpo]], [[4fpy]], [[4fq4]], [[4xe9]], [[4xhx]], [[4xil]], [[4xj9]], [[4xja]], [[4xju]], [[4xjw]], [[4xma]] - SpNANB (mutant) + inhibitor<br />
 +
**[[4xog]] - SpNANB (mutant) + neuraminic acid derivative + inhibitor<br />
 +
**[[2jkb]], [[4xj8]] - SpNANB residues 30-697 + sialic acid analog<br />
 +
**[[4c1w]] - SpNANB residues 52-236 + sialic acid derivative<br />
 +
**[[4xyx]] – SpNANB + drug<br />
 +
**[[4yw2]] – SpNANB residues 83-740 + sialic acid<br />
*'''Anhydrosialidase'''
*'''Anhydrosialidase'''

Current revision

3D structures of Neuraminidase

Updated on 13-July-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel

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