Lipase 3D Structures

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Current revision (08:50, 18 June 2023) (edit) (undo)
 
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*Prokaryote lipase:
*Prokaryote lipase:
-
**[[1llf]] – Lip – ''Candida cylindracea''<br />
+
**[[1lpm]], [[1lps]] – CrLip closed state – ''Candida rugosa'' <br />
 +
**[[1crl]], [[1trh]] – CrLip open state<br />
 +
*[[1llf]] – Lip – ''Candida cylindracea''<br />
**[[3g7n]] – Lip - ''Penicillium expansum''<br />
**[[3g7n]] – Lip - ''Penicillium expansum''<br />
**[[1tia]] - Lip – ''Penicillium camemberti''<br />
**[[1tia]] - Lip – ''Penicillium camemberti''<br />
 +
**[[5ch8]] – Lip (mutant) – ''Penicillium cyclopium''<br />
 +
**[[6l7n]] – Lip – ''Penicillium roqueforti''<br />
**[[2hih]] – Lip – ''Staphylococcus hyicus''<br />
**[[2hih]] – Lip – ''Staphylococcus hyicus''<br />
**[[2fx5]] – Lip – ''Pseudomonas mendocina''<br />
**[[2fx5]] – Lip – ''Pseudomonas mendocina''<br />
**[[1yzf]] – Lip – ''Enterococcus faecalis''<br />
**[[1yzf]] – Lip – ''Enterococcus faecalis''<br />
-
**[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]], [[4zgb]], [[6hw1]] - TlLip - ''Thermomyces lanuginose''<br />
+
**[[1dt3]], [[1dt5]], [[1dte]], [[1du4]], [[1ein]], [[1tib]], [[4dyh]], [[4ea6]], [[4flf]], [[4gbg]], [[4gwl]], [[4zgb]], [[6hw1]], [[6xok]], [[6xrv]], [[6xs3]], [[7apn]], [[7app]] - TlLip - ''Thermomyces lanuginose''<br />
**[[5ap9]] – TlLip (mutant)<br />
**[[5ap9]] – TlLip (mutant)<br />
**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
**[[1jfr]] – Lip – ''Streptomyces exfoliates''<br />
Line 48: Line 52:
**[[2ory]] – Lip – ''Photobacterium lypoliticum''<br />
**[[2ory]] – Lip – ''Photobacterium lypoliticum''<br />
**[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae''<br />
**[[2z5g]], [[2dsn]] – GzLip T1 – ''Geobacillus zalihae''<br />
-
**[[3umj]] – GzLip (mutant)<br />
+
**[[3umj]], [[7buk]] – GzLip (mutant)<br />
**[[3p94]] – Lip – ''Parabacteroides distasonis''<br />
**[[3p94]] – Lip – ''Parabacteroides distasonis''<br />
**[[3ngm]] – Lip – ''Gibberella zeae''<br />
**[[3ngm]] – Lip – ''Gibberella zeae''<br />
**[[3auk]] - Lip – ''Geobacillus''<br />
**[[3auk]] - Lip – ''Geobacillus''<br />
**[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa''<br />
**[[3uue]], [[3uuf]] – Lip – ''Malassezia globosa''<br />
-
**[[4hs9]] – Lip – ''Proteus mirabilis''<br />
+
**[[4hs9]] – PmLip – ''Proteus mirabilis''<br />
 +
**[[6jd9]] – PmLip (mutant) <br />
**[[4opm]] – Lip – ''Acinetobacter baumannii''<br />
**[[4opm]] – Lip – ''Acinetobacter baumannii''<br />
**[[5ah0]] – Lip – ''Pelosinus fermentans''<br />
**[[5ah0]] – Lip – ''Pelosinus fermentans''<br />
**[[5ah1]] – Lip – ''Clostridium botulinum''<br />
**[[5ah1]] – Lip – ''Clostridium botulinum''<br />
-
**[[5ch8]] – Lip (mutant) – ''Penicillium cyclopium''<br />
+
**[[6khm]] – CuaLip open form – ''Cutibacterium acnes''<br />
 +
**[[6khk]], [[6khl]] – CuaLip closed form <br />
 +
**[[6nkc]], [[6nkd]], [[6nkf]], [[6nkg]] – Lip – goat metagenome<br />
 +
**[[7q4h]] – TtLip – Thermoanaerobacter thermohydrosulfuricus<br />
 +
 
*Bacterial lipase A
*Bacterial lipase A
Line 68: Line 77:
**[[1r4z]] – BsLipA+Rc-IPG-phosphonate<br />
**[[1r4z]] – BsLipA+Rc-IPG-phosphonate<br />
**[[1r50]] – BsLipA +Sc-IPG-phosphonate<br />
**[[1r50]] – BsLipA +Sc-IPG-phosphonate<br />
 +
**[[7r1k]], [[7r25]] – LipA – ''Bacillus pumilus''<br />
*Bacterial lipase B
*Bacterial lipase B
Line 74: Line 84:
**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]] – CaLipB (mutant) <br />
**[[3icv]], [[4k5q]], [[5k6h]], [[5k6k]] – CaLipB (mutant) <br />
**[[5gv5]] - CaLipB + phosphonate<br />
**[[5gv5]] - CaLipB + phosphonate<br />
 +
**[[4k6h]] – CaLipB (mutant) <br />
**[[3icw]] – CaLipB (mutant) + phosphonate<br />
**[[3icw]] – CaLipB (mutant) + phosphonate<br />
**[[5x7k]] – SmLipB NBD <br />
**[[5x7k]] – SmLipB NBD <br />
Line 80: Line 91:
**[[6tp8]] – PaLipB + substrate<br />
**[[6tp8]] – PaLipB + substrate<br />
**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />
**[[6idy]] - AfLipB - ''Aspergillus fumigatus''<br />
 +
**[[7v6d]] - LipB - ''Lasiodiplodia theobromae''<br />
 +
**[[7wol]] - LipB - ''Thermomicrobium roseum''<br />
*Bacterial lipase C
*Bacterial lipase C
Line 96: Line 109:
**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />
**[[1evq]] – AaEst2(LIPE) – ''Alicyclobacillus acidocaldarius''<br />
**[[1u4n]] – AaEst2(LIPE) (mutant) <br />
**[[1u4n]] – AaEst2(LIPE) (mutant) <br />
-
**[[6keu]] – ElEstE53(HSL) – ''Erythrobacter longus''<br />
+
**[[6keu]], [[7ci0]], [[7cip]], [[7w8n]] – ElEstE53(HSL) – ''Erythrobacter longus''<br />
-
**[[6kf1]], [[6kf5]], [[6kf7]] – ElEstE53(HSL) (mutant)<br />
+
**[[6kf1]], [[6kf5]], [[6kf7]], [[7cih]] – ElEstE53(HSL) (mutant)<br />
-
 
+
-
*Putative lipases; Proteins with unknown function but structural similarity to lipase obtained in structural genomics projects.
+
-
 
+
-
**[[2rau]] - Lip – ''Sulfolobus solfataricus''<br />
+
-
**[[3bxp]], [[3d3n]] - Lip – ''Lactobacillus plantarum''<br />
+
-
**[[3e0x]] - Lip – ''Clostridium acetobutylicum''<br />
+
-
**[[1z8h]] – Lip – ''Nostoc sp.'' PCC 712<br />
+
-
**[[1vj3]] - Lip – ''Nostoc sp.'' <br />
+
-
**[[3bzw]] – Lip - ''Bacteroides thetaiotaomicron''<br />
+
-
**[[2pbl]] – Lip - ''Silicibacter''
+
*Lipase + inhibitors
*Lipase + inhibitors
Line 131: Line 134:
**[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate<br />
**[[4n8s]] - TlLip + nitrobenzaldehyde + ethylacetoacetate<br />
**[[4s0x]] – TlLip + lauric acid<br />
**[[4s0x]] – TlLip + lauric acid<br />
 +
**[[4gxn]] – PmLip + inhibitor<br />
*Lipase conjugated with analogs to its reaction intermediates
*Lipase conjugated with analogs to its reaction intermediates
 +
**[[1lpn]] – CrLip+ dodecanesulfonate <br />
 +
**[[1lpo]], [[1lpp]] – CrLip+ hexadecanesulfonate<br />
 +
**[[3rar]] – CrLip + phosphonate derivative<br />
**[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br />
**[[1qz3]] – EaEst2(mutant) (LIPE)+hexadecanesulfonate <br />
Line 144: Line 151:
*Monoacylglycerol lipase
*Monoacylglycerol lipase
-
**[[3hju]], [[3jw8]] - hMAGL <BR />
+
**[[3hju]], [[3jw8]], [[7ots]] - hMAGL <BR />
-
**[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]] – hMAGL + inhibitor<br />
+
**[[3jwe]], [[3pe6]], [[4uuq]], [[6ax1]], [[6bq0]], [[7l4t]], [[7l4u]], [[7l4w]], [[7l50]], [[7prm]], [[7zpg]] – hMAGL + inhibitor<br />
**[[4uuq]] - hMAGLip + SAR <br />
**[[4uuq]] - hMAGLip + SAR <br />
**[[5zun]] – hMAGL (mutant) + inhibitor<br />
**[[5zun]] – hMAGL (mutant) + inhibitor<br />
-
**[[3rm3]], [[4lhe]], [[5xks]] - BaMAGL – ''Bacillus'' <BR />
 
-
**[[3rli]] – BaMAGL + PMSF<br />
 
-
**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />
 
-
**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />
 
**[[4zwn]] – yMAGL – yeast<br />
**[[4zwn]] – yMAGL – yeast<br />
**[[4zxf]] – yMAGLip + substrate analog<br />
**[[4zxf]] – yMAGLip + substrate analog<br />
-
**[[6eic]], [[6k34]] – MAGLip – ''Mycobacterium tuberculosis''<br />
+
**[[6eic]], [[6k34]] – MtMAGLip – ''Mycobacterium tuberculosis''<br />
 +
**[[7ozm]], [[7p0y]] – MtMAGL (mutant) <br />
**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
**[[5xk2]] – MAGLip – ''Aespergillus oryzae''<br />
**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />
**[[6qe2]] – MAGLip – ''Plaeococcus ferrophilus''<br />
 +
**[[3rm3]], [[4lhe]], [[5xks]] - BaMAGL – ''Bacillus'' <BR />
 +
**[[3rli]] – BaMAGL + PMSF<br />
 +
**[[4ke7]], [[4ke8]], [[4ke9]] – BaMAGL + ligand<br />
 +
**[[4ke6]], [[4kea]] – BaMAGL (mutant) + ligand<br />
 +
**[[7q4j]] – TtLip + monoacylglycerol intermediate<br />
 +
**[[7e04]] – Lip – ''Cytobacillus oceanisediminis''<br />
*Triacylglycerol lipase
*Triacylglycerol lipase
Line 202: Line 212:
**[[6oau]], [[6e7k]], [[6oaz]], [[6ob0]] – hLPL + GPIHBP1<br />
**[[6oau]], [[6e7k]], [[6oaz]], [[6ob0]] – hLPL + GPIHBP1<br />
-
**[[6u7m]] – bLPL – Cryo EM<br />
+
**[[6u7m]], [[8erl]] – bLPL – Cryo EM<br />
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Lipase

Updated on 18-June-2023


Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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