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Nitric Oxide Synthase 3D structures
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*Endothelial NOS; Domains – PDZ – 1-130; oxygenase (OD) 66-492; heme – 302-722; FAD/NADP – 963-1397 | *Endothelial NOS; Domains – PDZ – 1-130; oxygenase (OD) 66-492; heme – 302-722; FAD/NADP – 963-1397 | ||
| + | |||
| + | * Endothelial NOS oxygenase domain (OD) 66-492 | ||
**[[3nos]], [[4d1o]] – h-eNOS OD+arginine - human<br /> | **[[3nos]], [[4d1o]] – h-eNOS OD+arginine - human<br /> | ||
**[[1m9j]] – h-eNOS OD+chlorzoxazone<br /> | **[[1m9j]] – h-eNOS OD+chlorzoxazone<br /> | ||
| - | **[[1m9k]], [[1m9r]], [[4d1p]], [[6av7]], [[6av6]], [[6nhf]], [[6nh8]], [[6nh7]], [[6nh6]], [[6nh5]], [[6nh4]], [[6nh3]], [[6nh2]], [[6nh1]], [[6cif]], [[6cie]], [[3eah]] – h-eNOS OD+ inhibitor<br /> | + | **[[1m9k]], [[1m9r]], [[4d1p]], [[6av7]], [[6av6]], [[6nhf]], [[6nh8]], [[6nh7]], [[6nh6]], [[6nh5]], [[6nh4]], [[6nh3]], [[6nh2]], [[6nh1]], [[6cif]], [[6cie]], [[3eah]] – h-eNOS OD+ inhibitor<br /> |
**[[1nsi]] - h-eNOS OD+ Zn<br /> | **[[1nsi]] - h-eNOS OD+ Zn<br /> | ||
| - | **[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+ | + | **[[3nld]], [[3nle]], [[3nlf]], [[3nlg]], [[3jww]], [[3jwx]], [[3jwy]], [[3jwz]], [[3dqs]], [[3dqt]], [[3pnh]], [[4luw]] – b-eNOS OD+ pyridine derivative – bovine<br /> |
**[[1dm6]] – b-eNOS OD+guanidine derivative<br /> | **[[1dm6]] – b-eNOS OD+guanidine derivative<br /> | ||
| - | **[[3nlh]], [[3rqo]], [[3rqp]] – b-eNOS OD (mutant)+ | + | **[[3nlh]], [[3rqo]], [[3rqp]] – b-eNOS OD (mutant)+ pyridine derivative<br /> |
**[[1rs8]], [[1rs9]], [[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | **[[1rs8]], [[1rs9]], [[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | ||
**[[1nse]] – b-eNOS OD<br /> | **[[1nse]] – b-eNOS OD<br /> | ||
| - | **[[1p6n]] – b-eNOS OD +dipeptide inhibitor<br /> | ||
**[[5nse]], [[1fol]], [[1foo]], [[1fop]], [[1dm7]], [[2nse]], [[3nse]], [[4nse]] – b-eNOS OD+arginine derivative<br /> | **[[5nse]], [[1fol]], [[1foo]], [[1fop]], [[1dm7]], [[2nse]], [[3nse]], [[4nse]] – b-eNOS OD+arginine derivative<br /> | ||
| - | + | **[[7nse]] – b-eNOS OD+ADMA | |
| - | **[[7nse]] – b-eNOS OD+ADMA | + | **[[1d1v]], [[1d1x]], [[1d1y]], [[1ed4]], [[9nse]] – b-eNOS OD+urea derivative<br /> |
| - | ** | + | |
**[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br /> | **[[1dmj]], [[1dmk]] – b-eNOS OD+pterin derivative<br /> | ||
| - | **[[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]], [[3e7s]], [[5vv6]], [[5vv7]], [[5vv8 | + | **[[1foi]], [[1dmi]], [[1i83]], [[3n5p]], [[3n5q]], [[3n5r]], [[3n5s]], [[3n5t]], [[3n5v]], [[3n5w]], [[3n5x]], [[3n5y]], [[3n5z]], [[3n60]], [[3n61]], [[3n62]], [[3n63]], [[3n64]], [[3n65]], [[3n66]], [[3n67]], [[3n68]], [[3n69]], [[3n6a]], [[3n6b]], [[3n6c]], [[3n6d]], [[3n6e]], [[3n6f]], [[3n6g]], [[3nlt]], [[3nlu]], [[3e7s]], [[5vv6]], [[5vv7]], [[5vv8]], [[4upq]], [[4upr]], [[4ups]], [[4upt]], [[5vva]], [[5vvb]], [[5vvc]], [[5vvd]], [[5vvg]], [[5vvn]], [[5uo8]], [[5uo9]], [[5uoa]], [[5uob]], [[5uoc]], [[5uod]], [[5fvy]], [[5fvz]], [[5fj2]], [[5fj3]], [[5adj]], [[5adk]], [[5adl]], [[5adm]], [[5adn]], [[4d33]], [[4d34]], [[4d35]], [[4d36]], [[4d37]], [[4d38]], [[4d39]], [[4d3a]], [[4cul]], [[4cum]], [[4cun]], [[4cvg]], [[4cwv]], [[4cww]], [[4cwx]], [[4cwy]], [[4cty]], [[4ctz]], [[4cu0]], [[4cu1]], [[5vv9]] – b-eNOS OD+inhibitor<br /> |
**[[4cwz]], [[4cx0]], [[4cx1]], [[4cx2]] – b-eNOS OD (mutant) +inhibitor<br /> | **[[4cwz]], [[4cx0]], [[4cx1]], [[4cx2]] – b-eNOS OD (mutant) +inhibitor<br /> | ||
| - | **[[1d0c]], [[8nse]], [[1foj]], [[1ed5]], [[1d0o]], [[1d1w]] – b-eNOS OD+indazole derivative | + | **[[1d0c]], [[8nse]], [[1foj]], [[1ed5]], [[1d0o]], [[1d1w]] – b-eNOS OD+indazole derivative |
**[[1dm8]] – b-eNOS OD+triazole derivative<br /> | **[[1dm8]] – b-eNOS OD+triazole derivative<br /> | ||
**[[1ed6]] – b-eNOS OD+NO<br /> | **[[1ed6]] – b-eNOS OD+NO<br /> | ||
| + | |||
| + | * Endothelial NOS heme domain | ||
| + | |||
| + | **[[6pou]], [[6pov]], [[6pow]], [[6pox]], [[6poy]], [[6poz]], [[6pp0]], [[6pp1]], [[6pp2]], [[6pp3]], [[6pp4]], [[7m56]], [[7tsg]], [[7tsh]], [[7tsi]], [[7tsk]], [[7tsl]], [[7tsm]], [[7tsn]], [[7tso]], [[7tsp]], [[7uao]] – h-eNOS heme domain + inhibitor<br /> | ||
| + | **[[6ng1]], [[6ng2]], [[6ng4]], [[6ng5]], [[6ng6]], [[6ng7]], [[6ng8]], [[6nga]], [[6ngb]], [[6ngc]], [[6ngd]], [[6nge]], [[6ngf]], [[6ngh]], [[6ngi]] – h-eNOS heme domain (mutant) + inhibitor<br /> | ||
**[[1q2o]] – b-eNOS OD (mutant)+dipeptide inhibitor<br /> | **[[1q2o]] – b-eNOS OD (mutant)+dipeptide inhibitor<br /> | ||
| - | **[[ | + | **[[6nse]] - b-nNOS heme domain + canavanine<br /> |
| - | **[[ | + | **[[1p6l]], [[1p6m]] – r-eNOS OD +dipeptide inhibitor – rat<br /> |
**[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]], [[4c3a]] – r-eNOS OD+ pyridine derivative<br /> | **[[4jsk]], [[4jsl]], [[4jsm]], [[4imx]], [[4k5h]], [[4k5i]], [[4k5j]], [[4k5k]], [[4c3a]] – r-eNOS OD+ pyridine derivative<br /> | ||
| - | **[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD | + | **[[4kcp]], [[4kcq]], [[4kcr]], [[4kcs]] - r-eNOS OD +thiophene carboximidamide derivative<br /> |
| + | **[[4uh0]], [[4uh1]], [[4uh2]], [[4uh3]], [[4uh4]], [[4uh7]], [[4uh8]], [[4uh9]], [[4uha]], [[6ngj]], [[6ngk]], [[6ngl]], [[6ngm]], [[6ngn]], [[6ngp]], [[6ngq]], [[6ngr]], [[6ngs]], [[6ngt]], [[6ngu]], [[6ngv]], [[6ngw]], [[6ngx]], [[6ngy]], [[6ngz]], [[6nh0]] – r-eNOS heme domain + inhibitor<br /> | ||
| - | *Neuronal NOS | + | *Neuronal NOS; heme domain 297-718 |
| - | **[[4uh5]], [[6av5]], [[6av4]], [[6av3]] - h-nNOS heme domain +inhibitor<br /> | + | **[[4uh5]], [[6av5]], [[6av4]], [[6av3]], [[7ts8]], [[7tsf]] - h-nNOS heme domain +inhibitor<br /> |
| - | **[[4uh6]], [[4uch]], [[6av2]], [[6av1]], [[6av0]], [[6auz]], [[6auy]], [[5vv4]], [[5vv2]], [[5vv1]], [[5vuz]], [[5vuy]], [[5vux]], [[5vuw]], [[5vuv]], [[6nhb]], [[6nhc]], [[6cid]], [[6ng8]], [[6ngi]], [[6ngh]], [[6ngf]], [[6nge]], [[6ngd]], [[6ngc]], [[6ngb]], [[6nga]], [[6ng7]], [[6ng6]], [[6ng5]], [[6ng4]], [[6ng2]], [[6ng1]], [[6cic]] - h-nNOS heme domain + inhibitor<br /> | + | **[[4uh6]], [[4uch]], [[6av2]], [[6av1]], [[6av0]], [[6auz]], [[6auy]], [[5vv4]], [[5vv2]], [[5vv1]], [[5vuz]], [[5vuy]], [[5vux]], [[5vuw]], [[5vuv]], [[6nhb]], [[6nhc]], [[6cid]], [[6ng8]], [[6ngi]], [[6ngh]], [[6ngf]], [[6nge]], [[6ngd]], [[6ngc]], [[6ngb]], [[6nga]], [[6ng7]], [[6ng6]], [[6ng5]], [[6ng4]], [[6ng2]], [[6ng1]], [[6cic]], [[6nhb]], [[6nhc]], [[6pna]], [[6pnb]], [[6pnc]], [[6pnd]], [[6pne]], [[6pnf]], [[6png]], [[6pnh]], [[6po5]], [[6po7]], [[6po8]], [[6po9]], [[6poa]], [[6pob]], [[6poc]], [[6pot]], [[7ts1]], [[7ts2]], [[7ts3]], [[7ts4]], [[7ts5]], [[7ts6]], [[7ts6]], [[7uam]], [[7us7]], [[7us8]] - h-nNOS heme domain (mutant) +inhibitor<br /> |
**[[4d1n]] - h-nNOS heme domain (mutant) + arginine<br /> | **[[4d1n]] - h-nNOS heme domain (mutant) + arginine<br /> | ||
| + | **[[4cam]], [[4can]], [[4cao]], [[4cap]], [[4caq]], [[4car]], [[4cdt]], [[4cft]] – r-nNOS heme domain + quinoline derivative<br /> | ||
| + | **[[4kch]], [[4kci]], [[4kcj]], [[4kck]], [[4kcl]], [[4kcm]], [[4kcn]], [[4kco]] - r-nNOS heme domain +thiophene carboximidamide derivative<br /> | ||
| + | **[[6nhd]], [[6nhe]], [[6pmv]], [[6pmw]], [[6pmx]], [[6pmy]], [[6pmz]], [[6pn0]], [[6pn1]], [[6pn2]], [[6pn3]], [[6pn4]], [[6pn5]], [[6pn6]], [[6pn7]], [[6pn8]], [[6pn9]], [[7s3x]], [[7s3y]], [[7s3z]], [[7s40]] - r-nNOS heme domain +inhibitor<br /> | ||
| + | **[[7ts9]], [[7tsa]], [[7tsb]], [[7tsc]], [[7tsd]], [[7tse]], [[7uan]] - r-nNOS heme domain (mutant) + inhibitor<br /> | ||
| + | |||
| + | *Neuronal NOS; oxygenase domain (OD) 297-718 | ||
| + | |||
**[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br /> | **[[2hx2]] – b-nNOS OD+nitroguanidine derivative<br /> | ||
| - | **[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0 | + | **[[3nlv]], [[3nlw]], [[3nlx]], [[3nly]], [[3nlz]], [[3nm0]] - b-nNOS OD + inhibitor<br /> |
| - | ** | + | **[[3nlj]], [[3nlk]], [[3nln]], [[3nlo]], [[3nlp]], [[3nlq]], [[3nlr]], [[3jws]], [[3jwt]], [[3jwu]], [[3jwv]], [[3jx0]], [[3jx1]], [[3jx2]], [[3jx3]], [[3jx4]], [[3jx5]], [[3jx6]], [[3pne]], [[3pnf]], [[3png]], [[3svp]], [[3svq]] – r-nNOS OD (mutant)+pyridine derivative <br /> |
| - | **[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]], [[3rqj]], [[3rqk]], [[3rql]], [[3rqm]], [[3rqn]], [[3tyl]], [[3tym]], [[3tyn]], [[3tyo]], [[4ims]], [[4imt]], [[4imu]], [[4imw]], [[4jse]], [[4jsf]], [[4jsg]], [[4jsh]], [[4jsi]], [[4jsj]], [[4k5d]], [[4k5e]], [[4k5f]], [[4k5g]], [[4lux]] | + | **[[3nlm]], [[3nny]], [[3nnz]], [[3n2r]], [[3b3o]], [[3b3p]], [[3b3m]], [[3b3n]], [[3rqj]], [[3rqk]], [[3rql]], [[3rqm]], [[3rqn]], [[3tyl]], [[3tym]], [[3tyn]], [[3tyo]], [[4ims]], [[4imt]], [[4imu]], [[4imw]], [[4jse]], [[4jsf]], [[4jsg]], [[4jsh]], [[4jsi]], [[4jsj]], [[4k5d]], [[4k5e]], [[4k5f]], [[4k5g]], [[4lux]] – r-nNOS OD+ pyridine derivative<br /> |
| + | **[[1om4]], [[1k2r]], [[1k2s]], [[1lzx]], [[2hx4]], [[1zvl]], [[1qw6]], [[4fvw]], [[4fvx]], [[4fvy]], [[4fvz]], [[4fw0]] – r-nNOS OD+arginine derivative<br /> | ||
**[[4gqe]] – r-nNOS OD + norvaline derivative<br /> | **[[4gqe]] – r-nNOS OD + norvaline derivative<br /> | ||
| - | **[[1om4]], [[1k2r]], [[1k2s]], [[1lzx]], [[2hx4]], [[1zvl]], [[1qw6]], [[4fvw]], [[4fvx]], [[4fvy]], [[4fvz]], [[4fw0]] - r-nNOS OD+arginine derivative<br /> | ||
| - | **[[4cam]], [[4can]], [[4cao]], [[4cap]], [[4caq]], [[4car]], [[4cdt]], [[4cft]] – r-nNOS heme domain + quinoline derivative<br /> | ||
**[[1k2t]], [[1k2u]] – r-nNOS OD+thiourea derivative<br /> | **[[1k2t]], [[1k2u]] – r-nNOS OD+thiourea derivative<br /> | ||
**[[1om5]] – r-nNOS OD+indazole derivative<br /> | **[[1om5]] – r-nNOS OD+indazole derivative<br /> | ||
| - | **[[1lzz]], [[1m00]], [[2hx3]]– r-nNOS OD+guanidine | + | **[[1lzz]], [[1m00]], [[2hx3]] – r-nNOS OD+guanidine derivative<br /> |
| - | + | ||
**[[3fc5]], [[1zvi]] – r-nNOS OD<br /> | **[[3fc5]], [[1zvi]] – r-nNOS OD<br /> | ||
| - | + | **[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]], [[5vui]], [[4upm]], [[4upn]], [[4upo]], [[4upp]], [[5vuk]], [[5vul]], [[5vum]], [[5vun]], [[5vuo]], [[5vup]], [[5vuq]], [[5vur]], [[5vus]], [[5vut]], [[5vuu]], [[5unr]], [[5unt]], [[5unu]], [[5unv]], [[5unw]], [[5unx]], [[5uny]], [[5unz]], [[5uo0]], [[5fw0]], [[5fvo]], [[5fvp]], [[5fvq]], [[5fvr]], [[5fvs]], [[5fvt]], [[5agk]], [[5agl]], [[5agm]], [[5agn]], [[5ago]], [[5agp]], [[4v3v]], [[4v3w]], [[4v3x]], [[4v3y]], [[4v3z]], [[5ad4]], [[5ad5]], [[5ad6]], [[5ad7]], [[5ad8]], [[5ad9]], [[5ada]], [[5adb]], [[5adc]], [[4ugz]], [[4d33]], [[4d34]], [[4d35]], [[4d2y]], [[4d1z]], [[4d30]], [[4d31]], [[4d7o]], [[4d3b]], [[4d32]], [[4ctp]], [[4ctq]], [[4ctr]], [[4ctt]], [[4ctu]], [[4ctv]], [[4c39]], [[6aux]], [[6auw]], [[6auv]], [[6auu]], [[6aut]], [[6aur]], [[6auq]], [[5vuj]], [[4d2z]], [[4ctx]], [[4ctw]], [[6nhe]], [[6nhd]], [[6nh0]], [[6ngz]], [[6ngy]], [[6ngx]], [[6ngw]], [[6ngv]], [[6ngu]], [[6ngt]], [[6ngs]], [[6ngr]], [[6ngq]], [[6ngp]], [[6ngn]], [[6ngm]], [[6ngl]], [[6ngk]], [[6ngj]], [[7tsf]] – r-nNOS OD+inhibitor<br /> | |
| - | + | **[[5vv0]], [[5vv3]], [[5vv5]], [[5uns]], [[5uo1]], [[5uo2]], [[5uo3]], [[5uo4]], [[5uo5]], [[5uo6]], [[5uo7]], [[5g0n]], [[5g0p]], [[5fvu]], [[5fvv]], [[5fvx]], [[5fvw]], [[4v3u]], [[5add]], [[5ade]], [[5adf]], [[5adg]], [[5adi]], [[4cx3]], [[4cx4]], [[4cx5]], [[4cx6]], [[6aus]], [[5g0o]] – r-nNOS OD (mutant) +inhibitor<br /> | |
| - | **[[1qwc]], [[3q99]], [[3q9a]], [[1mmv]], [[1mmw]], [[3dqr]], [[3ufo]], [[3ufp]], [[3ufq]], [[3ufr]], [[3ufs]], [[3uft]], [[3ufu]], [[3ufv]], [[3ufw]], [[4eux]], [[5vui]], [[4upm]], [[4upn]], [[4upo]], [[4upp]], [[5vuk]], [[5vul]], [[5vum]], [[5vun]], [[5vuo]], [[5vup]], [[5vuq]], [[5vur]], [[5vus]], [[5vut]], [[5vuu]], [[5unr]], [[5unt]], [[5unu]], [[5unv]], [[5unw]], [[5unx]], [[5uny]], [[5unz]], [[5uo0]], [[5fw0]], [[5fvo]], [[5fvp]], [[5fvq]], [[5fvr]], [[5fvs]], [[5fvt]], [[5agk]], [[5agl]], [[5agm]], [[5agn]], [[5ago]], [[5agp]], [[4v3v]], [[4v3w]], [[4v3x]], [[4v3y]], [[4v3z]], [[5ad4]], [[5ad5]], [[5ad6]], [[5ad7]], [[5ad8]], [[5ad9]], [[5ada]], [[5adb]], [[5adc]], [[4ugz]], [[4d33]], [[4d34]], [[4d35]], [[4d2y]], [[4d1z]], [[4d30]], [[4d31 | + | |
| - | **[[5vv0]], [[5vv3]], [[5vv5]], [[5uns]], [[5uo1]], [[5uo2]], [[5uo3]], [[5uo4]], [[5uo5]], [[5uo6]], [[5uo7]], [[5g0n]], [[5g0p]], [[5fvu]], [[5fvv]], [[5fvx]], [[5fvw | + | |
**[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br /> | **[[3jt3]], [[3jt4]], [[3jt5]], [[3jt6]], [[3jt7]], [[3jt8]], [[3jt9]], [[3jta]] – r-nNOS OD+ornithine derivative<br /> | ||
**[[3hsn]] – r-nNOS OD+NHA+CO<br /> | **[[3hsn]] – r-nNOS OD+NHA+CO<br /> | ||
| - | **[[3hso]], [[3hsp]] - | + | **[[3hso]], [[3hsp]] - r-nNOS OD+NHA+NO<br /> |
**[[2g6h]], [[2g6i]], [[2g6j]] – r-nNOS OD+pterin derivative<br /> | **[[2g6h]], [[2g6i]], [[2g6j]] – r-nNOS OD+pterin derivative<br /> | ||
**[[2g6k]], [[2g6l]] – r-nNOS OD+pterin derivative+NO<br /> | **[[2g6k]], [[2g6l]] – r-nNOS OD+pterin derivative+NO<br /> | ||
| Line 61: | Line 70: | ||
**[[1zzq]], [[1zzr]], [[1zzs]], [[1zzt]], [[1zzu]], [[1p6k]] – r-nNOS OD (mutant)+dipeptide inhibitor<br /> | **[[1zzq]], [[1zzr]], [[1zzs]], [[1zzt]], [[1zzu]], [[1p6k]] – r-nNOS OD (mutant)+dipeptide inhibitor<br /> | ||
**[[1rs6]], [[1rs7]], [[1p6h]], [[1p6i]], [[1p6j]] – r-nNOS OD +dipeptide inhibitor<br /> | **[[1rs6]], [[1rs7]], [[1p6h]], [[1p6i]], [[1p6j]] – r-nNOS OD +dipeptide inhibitor<br /> | ||
| + | **[[1vag]] – m-nNOS OD+inhibitor – mouse<br /> | ||
| + | |||
| + | *Neuronal NOS; other domains | ||
| + | |||
| + | **[[1qau]] - r-nNOS PDZ domain<br /> | ||
| + | **[[1qav]], [[4hop]] - r-nNOS PDZ domain + α-1 syntrophin<br /> | ||
**[[1b8q]] – r-nNOS PDZ domain + heptapeptide<br /> | **[[1b8q]] – r-nNOS PDZ domain + heptapeptide<br /> | ||
**[[1f20]] - r-nNOS FAD/NADP domain<br /> | **[[1f20]] - r-nNOS FAD/NADP domain<br /> | ||
| - | **[[ | + | **[[1tll]] – r-nNOS resdues 742-1429<br /> |
| + | |||
| + | *Inducible NOS | ||
| - | *Inducible NOS | ||
| - | |||
**[[3hr4]] – h-iNOS residues 503-715+calmodulin <br /> | **[[3hr4]] – h-iNOS residues 503-715+calmodulin <br /> | ||
**[[4nos]], [[4cx7]], [[3e7g]], [[3ej8]] – h-iNOS OD+inhibitor<br /> | **[[4nos]], [[4cx7]], [[3e7g]], [[3ej8]] – h-iNOS OD+inhibitor<br /> | ||
| - | **[[ | + | **[[4nsi]] – h-iNOS OD+arginine<br /> |
**[[2nsi]] – h-iNOS OD+thiourea derivative<br /> | **[[2nsi]] – h-iNOS OD+thiourea derivative<br /> | ||
| - | **[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]] – m-iNOS OD + pterin derivative<br /> | + | **[[6key]] - h-iNOS OD + SOCS box protein<br /> |
| + | **[[3nqs]], [[3e65]], [[3eai]], [[3ebd]], [[3ebf]], [[1r35]], [[2nod]] – m-iNOS OD + pterin derivative <br /> | ||
**[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br /> | **[[1jwj]], [[1jwk]] – m-iNOS OD (mutant)+ pterin derivative<br /> | ||
**[[4ux6]] – m-iNOS OD + pterin derivative + inhibitor<br /> | **[[4ux6]] – m-iNOS OD + pterin derivative + inhibitor<br /> | ||
| Line 78: | Line 94: | ||
**[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br /> | **[[1noc]] – m-iNOS OD+chloramphenicol acetyltransferase<br /> | ||
**[[3e67]] – m-iNOS OD+4-MAP<br /> | **[[3e67]] – m-iNOS OD+4-MAP<br /> | ||
| - | **[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+ | + | **[[3e68]], [[3e6l]], [[3e6n]], [[3e6o]], [[3e6t]], [[3e7i]], [[3e7m]], [[3e7t]], [[1vaf]], [[1qw5]], [[1dd7]], [[2y37]] – m-iNOS OD+inhibitor <br /> |
**[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]], [[3nw2]] – m-iNOS OD+imidazole derivative<br /> | **[[2orq]], [[2orr]], [[2ors]], [[2ort]], [[2oro]], [[2orp]], [[1nos]], [[3nw2]] – m-iNOS OD+imidazole derivative<br /> | ||
**[[1df1]] - m-iNOS OD+ urea derivative<br /> | **[[1df1]] - m-iNOS OD+ urea derivative<br /> | ||
| Line 89: | Line 105: | ||
**[[1m8d]] – m-iNOS OD+chlorzoxazone<br /> | **[[1m8d]] – m-iNOS OD+chlorzoxazone<br /> | ||
**[[1m8e]], [[1m8h]], [[1m8i]], [[1m9m]], [[1m9q]] – m-iNOS OD+ indazole derivative<br /> | **[[1m8e]], [[1m8h]], [[1m8i]], [[1m9m]], [[1m9q]] – m-iNOS OD+ indazole derivative<br /> | ||
| - | **[[1jwj]] – m-iNOS OD + inhibitor<br /> | ||
| - | **[[1jwk]] - m-iNOS OD (mutant) + inhibitor<br /> | ||
**[[3gof]] - c-iNOS OD + calmodulin – chicken<br /> | **[[3gof]] - c-iNOS OD + calmodulin – chicken<br /> | ||
| Line 99: | Line 113: | ||
**[[2fbz]], [[2fc2]], [[2fc1]] – BsNOS+NO<br /> | **[[2fbz]], [[2fc2]], [[2fc1]] – BsNOS+NO<br /> | ||
**[[1m7v]], [[1m7z]] – BsNOS+THF+arginine<br /> | **[[1m7v]], [[1m7z]] – BsNOS+THF+arginine<br /> | ||
| - | **[[5g67]], [[5g6q]], [[5g6p]], [[5g6o]], [[5g6n]], [[5g6m]], [[5g6l]], [[5g6k]], [[5g6j]], [[5g6i]], [[5g6h]], [[5g6g]], [[5g6f]], [[5g6e]], [[5g6d]], [[5g6c]], [[5g6b]], [[5g6a]], [[5g69]], [[5g68]], [[5g66]], [[5g65]], [[4ugl]], [[4uqs]], [[4uqr]], [[4ugy]], [[4ugx]], [[4ugw]], [[4ugv]], [[4ugu]], [[4ugt]], [[4ugs]], [[4ugr]], [[4ugq]], [[4ugp]], [[4ugo]], [[4ugn]], [[4ugm]], [[4ugk]], [[4ugj]], [[4ugi]], [[4ugh]], [[4ugg]], [[4ugf]], [[4uge]], [[4ugd]], [[4ugc]], [[4ugb]], [[4uga]], [[4ug9]], [[4ug8]], [[4ug7]], [[4ug6]], [[4ug5]], [[4lwb]], [[4lwa]], [[4d7j]], [[4d7i]], [[4d7h]], [[4d3v]], [[4d3u]], [[4d3t]], [[4d3o]], [[4d3n]], [[4d3m]], [[4d3k]], [[4d3j]], [[4d3i]] – BsNOS (mutant) | + | **[[6xcx]], [[6xk3]], [[6xk4]], [[6xk5]], [[6xk6]], [[[6xk7]], [6xk8]], [[6xmc]] – BsNOS + inhibitor<br /> |
| - | **[[2flq]] – NOS+arginine – ''Geobacillus stearothermophilus'' | + | **[[5g67]], [[5g6q]], [[5g6p]], [[5g6o]], [[5g6n]], [[5g6m]], [[5g6l]], [[5g6k]], [[5g6j]], [[5g6i]], [[5g6h]], [[5g6g]], [[5g6f]], [[5g6e]], [[5g6d]], [[5g6c]], [[5g6b]], [[5g6a]], [[5g69]], [[5g68]], [[5g66]], [[5g65]], [[4ugl]], [[4uqs]], [[4uqr]], [[4ugy]], [[4ugx]], [[4ugw]], [[4ugv]], [[4ugu]], [[4ugt]], [[4ugs]], [[4ugr]], [[4ugq]], [[4ugp]], [[4ugo]], [[4ugn]], [[4ugm]], [[4ugk]], [[4ugj]], [[4ugi]], [[4ugh]], [[4ugg]], [[4ugf]], [[4uge]], [[4ugd]], [[4ugc]], [[4ugb]], [[4uga]], [[4ug9]], [[4ug8]], [[4ug7]], [[4ug6]], [[4ug5]], [[4lwb]], [[4lwa]], [[4d7j]], [[4d7i]], [[4d7h]], [[4d3v]], [[4d3u]], [[4d3t]], [[4d3o]], [[4d3n]], [[4d3m]], [[4d3k]], [[4d3j]], [[4d3i]] – BsNOS (mutant) + inhibitor<br /> |
| + | **[[2flq]] – NOS+arginine – ''Geobacillus stearothermophilus'' | ||
| + | |||
}} | }} | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
3D Structures of Nitric Oxide Synthase
Updated on 17-July-2023
