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Nonstructural protein 3D structures

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*Nonstructural protein
*Nonstructural protein
-
**[[3o9q]], [[4opa]], [[4oph]] – IvNS1 (mutant) – Influenza virus<br />
+
**[[3o9q]], [[4opa]], [[4oph]], [[6nrl]], [[6o01]], [[6oqe]] – IvNS1 (mutant) – Influenza virus<br />
**[[3o9r]], [[3o9s]], [[3o9t]], [[3o9u]], [[3f5t]] – IvNS1<br />
**[[3o9r]], [[3o9s]], [[3o9t]], [[3o9u]], [[3f5t]] – IvNS1<br />
-
**[[3m8a]], [[2z0a]], [[1xeq]], [[1ail]] – IvNS1 RNA-binding domain<br />
+
**[[3m8a]], [[2z0a]], [[1xeq]], [[1ail]], [[6sw8]] – IvNS1 RNA-binding domain 2-73<br />
-
**[[3p31]] – IvNS1 C terminal effector domain<br />
+
-
**[[3p38]], [[3p39]] – IvNS1 C terminal effector domain (mutant)<br />
+
**[[1ns1]] - IvNS1 RNA-binding domain - NMR<br />
**[[1ns1]] - IvNS1 RNA-binding domain - NMR<br />
 +
**[[3p31]] – IvNS1 C terminal effector domain<br />
 +
**[[3p38]], [[3p39]] – IvNS1 C terminal effector domain (mutant) <br />
**[[3m5r]], [[2gx9]] - IvNS1 effector domain<br />
**[[3m5r]], [[2gx9]] - IvNS1 effector domain<br />
 +
**[[6nu0]] - IvNS1 effector domain 1-230 – NMR<br />
 +
**[[6dgn]] - IvNS1 effector domain (mutant) 86-205<br />
**[[1pd3]] – IvNS2 M1-binding domain<br />
**[[1pd3]] – IvNS2 M1-binding domain<br />
**[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dengue virus<br />
**[[3l6p]], [[3lkw]] – DvNS2B/3 protease domain (mutant) – Dengue virus<br />
-
**[[4r05]] – DvNS5 residues 2491-2752 <br />
+
**[[2o1j]] – RvNSP4 diarrhea-inducing domain – Human rotavirus<br />
-
**[[2o1j]] – RvNSP4 diarrhea-inducing domain – human rotavirus<br />
+
**[[2gu0]], [[6auk]], [[6cy9]], [[7kpo]], [[7kpp]] – RvNS2<br />
-
**[[2gu0]] – RvNS2<br />
+
**[[5y2h]], [[5y2j]], [[5y9r]] – RvNSP4 diarrhea-inducing domain – bovine rotavirus<br />
-
**[[5y2h]], [[5y2j]], [[5y9r]] – NSP4 diarrhea-inducing domain – bovine rotavirus<br />
+
**[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
**[[2ajj]], [[2ajm]], [[2ajn]], [[2ajo]] – NS5A membrane-anchor domain – bovine viral diarrhea virus – NMR<br />
-
**[[1fw5]] – NSP1 membrane-binding domain – Semliki forest virus – NMR<br />
+
**[[1fw5]] – NS1 membrane-binding domain – Semliki forest virus – NMR<br />
-
**[[5vj2]] – NS1 – respiratory syncytial virus<br />
+
**[[5vj2]] – HrsvNS1 – Human respiratory syncytial virus<br />
 +
**[[7ldk]] – HrsvNS2<br />
**[[5i65]] – NS ORF1A – porcine reproductive and respiratory syndrome virus<br />
**[[5i65]] – NS ORF1A – porcine reproductive and respiratory syndrome virus<br />
 +
**[[6lpa]] – pcvNS1 – porcine corona virus<br />
 +
**[[6ln0]] – pcvNS3 <br />
 +
**[[6mwm]] – NS3 – bat corona virus - NMR<br />
**[[1qol]] – NSP20A (mutant) - Foot-and-mouth disease virus<br />
**[[1qol]] – NSP20A (mutant) - Foot-and-mouth disease virus<br />
**[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br />
**[[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 – Hepatitis C virus<br />
**[[1r7c]], [[1r7d]], [[1r7e]], [[1r7f]], [[1r7g]] - HvNS5A membrane-anchor domain - NMR<br />
**[[1r7c]], [[1r7d]], [[1r7e]], [[1r7f]], [[1r7g]] - HvNS5A membrane-anchor domain - NMR<br />
-
**[[2gdt]], [[2hsx]] – SvNS1 (mutant) – Sars coronavirus – NMR<br />
+
**[[8a55]] – SvNS1 N-terminal 11-125 – Sars coronavirus <br />
-
**[[7jtl]] – NS8 residues 18-121 – Sars-cov-2<br />
+
**[[7eq4]] – SvNS1 N-terminal 11-125 (mutant) <br />
-
**[[2jzd]], [[2jze]], [[2jzf]], [[2rnk]] – SvNS3 residues 527-651 – NMR<br />
+
**[[2gdt]], [[2hsx]] – SvNS1 N-terminal (mutant) – NMR<br />
-
**[[2kaf]] - SvNS3 residues 1473-1532 – NMR <br />
+
**[[7ci3]], [[7lhq]] – SvNS7A<br />
-
**[[2kys]] – SvNS7 – NMR<br />
+
**[[7bwq]] – SvNS9<br />
-
**[[2l8k]] – NS7 residues 1454-1575 – NMR<br />
+
**[[2l8k]] – NS7 residues 1454-1575 – Arterivirus - NMR<br />
-
**[[3mtv]] – NS1 residues 181-383 – PRRS virus <br />
+
**[[3mtv]] – PrrsvNS1 residues 181-383 – PRRS virus <br />
 +
**[[6jdr]], [[6jds]], [[6jdu]] – PrrsvNS10 <br />
**[[3zfn]], [[3zfo]], [[3zfq]], [[3zfp]], [[3zfr]], [[3zft]], [[3zfu]] – Npro (mutant) – Pestivirus<br />
**[[3zfn]], [[3zfo]], [[3zfq]], [[3zfp]], [[3zfr]], [[3zft]], [[3zfu]] – Npro (mutant) – Pestivirus<br />
 +
**[[4r05]] – DvNS5 residues 2491-2752 <br />
**[[4x2z]] – NS3 residues 1174-1483 – Avian infectious bronchitis virus<br />
**[[4x2z]] – NS3 residues 1174-1483 – Avian infectious bronchitis virus<br />
 +
**[[4cbg]], [[4cbh]], [[4cbl]], [[4cbm]] – NS3 – Swine fever virus<br />
 +
**[[2hwk]] – VeevNS2 – Venzuelan equine encephalitis virus<br />
 +
**[[8duf]] – VeevNS2 (mutant)<br />
 +
**[[6lp9]] – fipvNSP1 – Feline infectious peritonitis virus<br />
 +
**[[3ub0]] – fipvNSP6 + NSP7 <br />
 +
**[[6ivc]] – tgvNSP1 – transmissible gastroenteritis virus<br />
 +
**[[6ivd]] – tgvNSP1 (mutant)<br />
 +
**[[6n9y]] – NS1 – Bluetongue virus<br />
 +
**[[6vdo]] – HcvNS3 (mutant) – Hepacivirus C<br />
 +
**[[7oj4]], [[7jno]] – NS3 helicase domain – Tick-borne encephalitis virus<br />
 +
**[[7dop]] – CvNS1 – Chicungunya virus - Cryo EM<br />
-
*Nonstructural protein binary complex
+
*For Zika virus nonstructural proteins NS2B and NS3 see [[Virus protease]]
-
**[[2xbm]] – DvNS5 methyltransferase domain + RNA<br />
+
*Nonstructural protein complex
 +
 
 +
**[[6weq]], [[6wer]], [[7bsc]] – DvNS1 + antibody<br />
 +
**[[7k93]] – DvNS1 + scFv<br />
 +
**[[2xbm]] – DvNS5 methyltransferase domain + RNA <br />
**[[3p8z]] - DvNS5 methyltransferase domain + SAH + inhibitor<br />
**[[3p8z]] - DvNS5 methyltransferase domain + SAH + inhibitor<br />
**[[5cuq]] - DvNS5 methyltransferase domain + inhibitor<br />
**[[5cuq]] - DvNS5 methyltransferase domain + inhibitor<br />
Line 44: Line 66:
**[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br />
**[[2hye]] – SvNSV + DNA damage-binding protein + cullin-4A + ring-box protein – Simian virus 5<br />
**[[2b5l]] - SvNSV + DNA damage-binding protein<br />
**[[2b5l]] - SvNSV + DNA damage-binding protein<br />
-
**[[1nhv]], [[1nhu]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br />
+
**[[7t70]], [[7t8m]], [[7t8r]], [[7t9y]], [[7ta4]], [[7ta7]], [[7tb2]], [[7tbt]], [[7tc4]] - SvNSV + 3C-like proteinase<br />
 +
**[[1nhv]] – HvNS5B RNA-dependent RNA polymerase residues 2420-2989 + inhibitor<br />
**[[1dxp]], [[1dy8]], [[1dy9]], [[1w3c]] – HvNS4A + HvHelicase NS3<br />
**[[1dxp]], [[1dy8]], [[1dy9]], [[1w3c]] – HvNS4A + HvHelicase NS3<br />
**[[4k8b]] - HvNS4A + HvProtease NS3 + inhibitor<br />
**[[4k8b]] - HvNS4A + HvProtease NS3 + inhibitor<br />
**[[4a1t]], [[4a1x]] - HvNS4A + peptide inhibitor<br />
**[[4a1t]], [[4a1x]] - HvNS4A + peptide inhibitor<br />
-
**[[3phe]] – HvNS5B + quinolone derivative<br />
+
**[[3phe]]– HvNS5B + quinolone derivative<br />
-
**[[3ub0]] – NSP6 + NSP7 – Feline infectious peritonitis virus<br />
+
**[[6w4g]] – HvNS5B 2421-2981 + inhibitor<br />
**[[1knz]] – RvNSP34 N terminal + mRNA<br />
**[[1knz]] – RvNSP34 N terminal + mRNA<br />
**[[1lj2]] – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide<br />
**[[1lj2]] – RvNSP34 C terminal + eukaryotic protein synthesis initiation factor peptide<br />
**[[4r8r]] – DvNS5 residues 2491-2752 + adenosyl-Met<br />
**[[4r8r]] – DvNS5 residues 2491-2752 + adenosyl-Met<br />
**[[4r8s]] – DvNS5 residues 2491-2752 + sinefungin<br />
**[[4r8s]] – DvNS5 residues 2491-2752 + sinefungin<br />
-
**[[6ux2]] – NS5 residues 2789-3419 + P113 – Zika virus<br />
+
**[[6ux2]] – ZvNS5 residues 2789-3419 + P113 - Zika virus<br />
 +
**[[6wcz]] – ZvNS5 + hSTAT2<br />
 +
**[[6i7p]] – ZvNS5 + SAH<br />
 +
**[[7x01]] – CvNS1 + inhibitor – Cryo EM<br />
 +
**[[6jim]] – CvNS2 + RNA <br />
 +
**[[7fgg]], [[7fgh]], [[7fgi]] – CvNS1 + nucleotide – Cryo EM<br />
 +
**[[6jim]] – NS2 + RNA – Chicungunya virus<br />
 +
**[[6usm]] – NS1 + MBP – Human parvovirus<br />
 +
**[[6sx0]], [[6zlc]] – IvNS1 RNA-binding domain + RNA<br />
 +
**[[6sx2]] – IvNS1 RNA-binding domain (mutant) + RNA<br />
 +
**[[6e5u]] – IvNS1 + NXF1 + NXT1<br />
 +
**[[6mvo]] – HcvNS5B + inhibitor<br />
 +
**[[6qsn]] – NS5A + SAH – yellow fever virus<br />
 +
 
 +
*Nonstructural protein NS3 from SARS CoV-2; Domain 1564-1878 (papain-like protease), [[3241-3546 (3C-like proteinase) see [[Virus protease 3D structures]]
 +
 
 +
**[[2jzd]], [[2jze]], [[2jzf]], [[2rnk]] – SvNS3 residues 527-651 – NMR<br />
 +
**[[7kag]] – Sv2NS3 Ubl1 domain 819-929<br />
 +
**[[6vxs]], [[6wcf]], [[6wen]], [[6wey]], [[6ywk]], [[6ywm]], [[7kg3]], [[7kqo]], [[7kqw]], [[7kr0]], [[7kr1]] – Sv2NS3 macrodomain 1025-1191<br />
 +
**[[2kaf]] - SvNS3 residues 1473-1532 – NMR <br />
 +
**[[7lgo]] – Sv2NS3 NAB domain 1907-2021<br />
 +
**[[7rqg]] – Sv2NS3 Y3 domain 2662-2763<br />
 +
**[[7kxb]], [[7lg7]] – Sv2NS3 macrodomain + inhibitor<br />
 +
**[[6w02]], [[6woj]], [[6ywl]], [[7bf5]], [[7c33]], [[7cz4]], [[7kqp]] – Sv2NS3 macrodomain + ADP-ribose<br />
 +
**[[6w6y]], [[7nme]] – Sv2NS3 macrodomain + cyclic AMP<br />**
 +
**[[7bf4]] – Sv2NS3 macrodomain + GMP<br />
 +
**[[7bf3]] – Sv2NS3 macrodomain + adenosine<br />
 +
**[[7bf6]] – Sv2NS3 macrodomain + drug<br />
 +
**[[6yxj]] – Sv2NS3 macrodomain II 1207-1344 + Paip1<br />
 +
 
 +
*Other nonstructural protein from SARS CoV-2; SV2NS14 is proofreading exoribonuclease
 +
 
 +
**[[6zlw]], [[6zoj]], [[6zok]], [[6zol]], [[7k5i]] – Sv2NS1 in human 40S ribosome – Cryo EM<br />
 +
**[[6zmt]], [[6zn5]] – Sv2NS1 in human pre-40S-like ribosome – Cryo EM<br />
 +
**[[6zp4]], [[6zon]] – Sv2NS1 in human 43S ribosome – Cryo EM<br />
 +
**[[6zm7]], [[6zme]], [[6zmi]], [[6zmo]] – Sv2NS1 in human 80S ribosome – Cryo EM<br />
 +
**[[7jqb]], [[7jqc]] – Sv2NS1 in rabbit 40S ribosome – Cryo EM<br />
 +
**[[7opl]] – Sv2NS1 13-127 + DNA polymerase + DNA primase – Cryo EM<br />
 +
**[[7k7p]] – Sv2NS1 1-180<br />
 +
**[[7msw]], [[7msx]] – Sv2NS2 – Cryo EM<br />
 +
**[[7exm]] – Sv2NS2 181-456<br />
 +
**[[2kys]] – Sv2NS7 3837-3919 – NMR<br />
 +
**[[7jtl]] – Sv2NS8 residues 18-121 <br />
 +
**[[6w4b]], [[6wc1]], [[6wrb]], [[6wxd]] – Sv2NS9 residues 4141-4235<br />
 +
**[[6zct]], [[6zpe]], [[7nts]] – Sv2NS10 residues 4263-4384<br />
 +
**[[7orr]], [[7oru]], [[7orv]], [[7orw]] – Sv2NS10 residues 4263-4384 + imidazole derivative<br />
 +
**[[6z6i]] – Sv2NS10 residues 1024-1197 + ADP derivative<br />
 +
**[[5f22]], [[6m5i]], [[6wiq]], [[6wqd]], [[6wtc]], [[6xip]], [[6yhu]], [[7dcd]], [[7jlt]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134<br />
 +
**[[6m71]], [[7btf]], [[7bv1]], [[7bw4]], [[7d4f]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM<br />
 +
**[[6nur]], [[6nus]] – Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 – Cryo EM<br />
 +
**[[5rob]], [[6jyt]], [[6zsl]], [[7nio]] – SvNS13 <br />
 +
**[[5smk]], [[7qgi]] – proofreading exoribonuclease <br />
 +
**[[7diy]] – proofreading exoribonuclease residues 5926-6214 + Sv2NS10 residues 4254-4392<br />
 +
**[[6vww]], [[6w01]], [[6xdh]], [[7kf4]] – Sv2NS15 residues 6453-6798<br />
 +
**[[6w4h]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392<br />
 +
 
 +
*Other nonstructural protein from SARS CoV-2 complexes
 +
 
 +
**[[7ozu]], [[7ozv]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + RNA + replicase polyprotein – Cryo EM<br />
 +
**[[6xqb]], [[6yyt]], [[7bzf]], [[7c2k]], [[7cyq]], [[[7dte]], [7krn]], [[7kro]], [[7krp]], [[7l1f]], [[7oyg]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA – Cryo EM<br />
 +
**[[7aap]], [[7b3b]], [[7b3c]], [[7bv2]], [[7ctt]], [[7dfg]], [[7dfh]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + drug – Cryo EM<br />
 +
**[[7b3d]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + AMP – Cryo EM<br />
 +
**[[7rdx]], [[7rdz]], [[7re3]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + RNA + ADP + helicase – Cryo EM<br />
 +
**[[6xez]], [[7cxm]], [[7cxn]], [[7cyq]] – Sv2NS7 residues 3860-3930 + Sv2NS8 residues 4018-4134 + Sv2NS12 residues 4393-5324 + Sv2NS13 residues 5325-5925 + RNA – Cryo EM<br />
 +
**[[7n3k]] – Sv2NS9 residues 4141-4253 + drug<br />
 +
**[[7kri]] – Sv2NS9 residues 4141-4253 + pyrimidine derivative<br />
 +
**[[7mc5]], [[7mc6]] – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease<br />
 +
**[[7r2v]] – proofreading exoribonuclease + SAH<br />
 +
**[[7qif]] – proofreading exoribonuclease + MeGpppG<br />
 +
**[[5skw]], [[5skx]], [[5sky]], [[5skz]], [[5sl0]], [[5sl1]], [[5sl2]], [[5sl3]], [[5sl4]], [[5sl5]], [[5sl6]], [[5sl7]], [[5sl8]], [[5sl9]], [[5sla]], [[5slb]], [[5slc]], [[5sld]], [[5sle]], [[5slf]], [[5slg]], [[5slh]], [[5sli]], [[5slj]], [[5slk]], [[5sll]], [[5slm]], [[5sln]], [[5slo]], [[5slp]], [[5slq]], [[5slr]], [[5sls]], [[5slt]], [[5slu]] [[5slv]], [[5slw]], [[5slx]], [[5sly]], [[5slz]], [[5sm0]] [[5sm1]], [[5sm2]], [[5sm3]] [[5sm4]], [[5sm5]], [[[5sm6]] [[5sm7]], [[5sm8]], [5sm9]] [[5sma]], [[5smib], [[5smc]] [[5smd]], [[5sme]], [[5smf]], [[5smg]] [[5smh]], [[5smi]], [[5smk]] – proofreading exoribonuclease + inhibitor<br />
 +
**[[7n0b]], [[7n0c]], [[7n0d]] – Sv2NS10 residues 4254-4392 + proofreading exoribonuclease + RNA – Cryo EM<br />
 +
**[[5rl6]], [[5rl7]], [[5rl8]], [[5rl9]], [[5rlc]], [[5rld]], [[5rle]], [[5rlf]], [[5rlg]], [[5rlh]], [[5rli]], [[5rlj]], [[5rlk]], [[5rll]], [[5rlm]], [[5rln]], [[5rlo]], [[5rlp]], [[5rlq]], [[5rlr]], [[5rls]], [[5rlt]], [[5rlu]], [[5rlv]], [[5rlw]], [[5rly]], [[5rlz]], [[5rm0]], [[5rm1]], [[5rm2]], [[5rm3]], [[5rm4]], [[5rm5]], [[5rm6]], [[5rm7]], [[5rm8]], [[5rm9]], [[5rma]], [[5rmb]], [[5rmc]], [[5rmd]], [[5rme]], [[5rmf]], [[5rmg]], [[5rmh]], [[5rmi]], [[5rmj]], [[5rmk]] [[5rml]], [[5rmm]], [[7nng]] – SvNS13 + inhibitor<br />
 +
**[[7nn0]] – SvNS13 + AMPPNP<br />
 +
**[6wlc]], [[6x4i]], [[7k1l]] – Sv2NS15 residues 6453-6798 + uridine derivative<br />
 +
**[[6wxc]] – Sv2NS15 residues 6453-6798 + drug<br />
 +
**[[6w61]], [[6w75]], [[6wvn]], [[6xkm]], [[7bq7]], [[7c2i]], [[7c2j]], [[7jpe]], [[7koa]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM<br />
 +
**[[6wjt]], [[6wq3]], [[6wrz]], [[7jhe]], [[7lw3]], [[7lw4]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH<br />
 +
**[[7jib]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + SAM<br />
 +
**[[7jyy]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + RNA<br />
 +
**[[6wks]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAM + GpppA<br />
 +
**[[7jz0]], [[7l6r]], [[7l6t]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + SAH + RNA<br />
 +
**[[6wkq]], [[6yz1]] – Sv2NS16 residues 6799-7096 + Sv2NS10 residues 4254-4392 + sinefungin<br />
 +
**[[6yyt]] – Sv2NS12 residues 4393-5324 + Sv2NS8 residues 3943-4140 + Sv2NS7 residues 3860-3942 + RNA<br />
 +
 
}}
}}
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

3D Structures of Nonstructural protein

Updated on 03-April-2024

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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