7ab9

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(New page: '''Unreleased structure''' The entry 7ab9 is ON HOLD until Paper Publication Authors: Singh, A.K., Blaazer, A.R., Zara, L., de Esch, I.J.P., Leurs, R., Brown, D.G. Description: Crystal...)
Current revision (12:06, 1 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7ab9 is ON HOLD until Paper Publication
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==Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-656==
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<StructureSection load='7ab9' size='340' side='right'caption='[[7ab9]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7ab9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AB9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AB9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=QWZ:1-cycloheptyl-3-{4-methoxy-3-[2-(4-methoxyphenyl)ethoxy]phenyl}-4,4-dimethyl-4,5-dihydro-1H-pyrazol-5-one'>QWZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ab9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ab9 OCA], [https://pdbe.org/7ab9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ab9 RCSB], [https://www.ebi.ac.uk/pdbsum/7ab9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ab9 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Note=Genetic variations in PDE4D might be associated with susceptibility to stroke. PubMed:17006457 states that association with stroke has to be considered with caution. Defects in PDE4D are the cause of acrodysostosis type 2, with or without hormone resistance (ACRDYS2) [MIM:[https://omim.org/entry/614613 614613]. ACRDYS2 is a pleiotropic disorder characterized by skeletal, endocrine, and neurological abnormalities. Skeletal features include brachycephaly, midface hypoplasia with a small upturned nose, brachydactyly, and lumbar spinal stenosis. Endocrine abnormalities include hypothyroidism and hypogonadism in males and irregular menses in females. Developmental disability is a common finding but is variable in severity and can be associated with significant behavioral problems.<ref>PMID:22464250</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE4D_HUMAN PDE4D_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.<ref>PMID:15260978</ref> <ref>PMID:15576036</ref>
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Authors: Singh, A.K., Blaazer, A.R., Zara, L., de Esch, I.J.P., Leurs, R., Brown, D.G.
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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Description: Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-656
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Blaazer, A.R]]
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__TOC__
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[[Category: Brown, D.G]]
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</StructureSection>
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[[Category: De Esch, I.J.P]]
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[[Category: Homo sapiens]]
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[[Category: Singh, A.K]]
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[[Category: Large Structures]]
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[[Category: Zara, L]]
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[[Category: Blaazer AR]]
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[[Category: Leurs, R]]
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[[Category: Brown DG]]
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[[Category: Leurs R]]
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[[Category: Singh AK]]
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[[Category: Zara L]]
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[[Category: De Esch IJP]]

Current revision

Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-656

PDB ID 7ab9

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