7k0c
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7k0c is ON HOLD Authors: Kumar, N., Arthur, C.P., Ciferri, C., Matsumoto, M.L. Description: Structure of Secretory IgM Core [[Category: Unreleased ...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of Secretory IgM Core== | |
| + | <StructureSection load='7k0c' size='340' side='right'caption='[[7k0c]], [[Resolution|resolution]] 3.30Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7k0c]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K0C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K0C FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k0c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k0c OCA], [https://pdbe.org/7k0c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k0c RCSB], [https://www.ebi.ac.uk/pdbsum/7k0c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k0c ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PIGR_HUMAN PIGR_HUMAN] This receptor binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Immunoglobulins (Ig) A and M are the only human antibodies that form oligomers and undergo transcytosis to mucosal secretions via the polymeric Ig receptor (pIgR). When complexed with the J-chain (JC) and the secretory component (SC) of pIgR, secretory IgA and IgM (sIgA and sIgM) play critical roles in host-pathogen defense. Recently, we determined the structure of sIgA-Fc which elucidated the mechanism of polymeric IgA assembly and revealed an extensive binding interface between IgA-Fc, JC, and SC. Despite low sequence identity shared with IgA-Fc, IgM-Fc also undergoes JC-mediated assembly and binds pIgR. Here, we report the structure of sIgM-Fc and carryout a systematic comparison to sIgA-Fc. Our structural analysis reveals a remarkably conserved mechanism of JC-templated oligomerization and SC recognition of both IgM and IgA through a highly conserved network of interactions. These studies reveal the structurally conserved features of sIgM and sIgA required for function in mucosal immunity. | ||
| - | + | Structure of the human secretory immunoglobulin M core.,Kumar N, Arthur CP, Ciferri C, Matsumoto ML Structure. 2021 Jun 3;29(6):564-571.e3. doi: 10.1016/j.str.2021.01.002. Epub 2021 , Jan 28. PMID:33513362<ref>PMID:33513362</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 7k0c" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: Matsumoto | + | __TOC__ |
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arthur CP]] | ||
| + | [[Category: Ciferri C]] | ||
| + | [[Category: Kumar N]] | ||
| + | [[Category: Matsumoto ML]] | ||
Current revision
Structure of Secretory IgM Core
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