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7k1e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646== | |
| + | <StructureSection load='7k1e' size='340' side='right'caption='[[7k1e]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7k1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K1E FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=VQG:3,4-difluoro-N-[(1S)-1-{1-[(2R)-4-(hydroxyamino)-4-oxo-1-(5,6,7,8-tetrahydronaphthalen-2-yl)butan-2-yl]-1H-1,2,3-triazol-4-yl}ethyl]benzamide'>VQG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1e OCA], [https://pdbe.org/7k1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1e RCSB], [https://www.ebi.ac.uk/pdbsum/7k1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1e ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Liang | + | [[Category: Large Structures]] |
| + | [[Category: Bosc D]] | ||
| + | [[Category: Deprez R]] | ||
| + | [[Category: Liang WG]] | ||
| + | [[Category: Tang W]] | ||
Current revision
Crystal structure of human insulin degrading enzyme (IDE) in complex with compound BDM_88646
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Categories: Homo sapiens | Large Structures | Bosc D | Deprez R | Liang WG | Tang W
