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7k1w

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(New page: '''Unreleased structure''' The entry 7k1w is ON HOLD Authors: Description: Category: Unreleased Structures)
Current revision (14:54, 6 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 7k1w is ON HOLD
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==PIKfyve/Fig4/Vac14 complex centered on Fig4 - map3==
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<StructureSection load='7k1w' size='340' side='right'caption='[[7k1w]], [[Resolution|resolution]] 5.10&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7k1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7K1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7K1W FirstGlance]. <br>
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Description:
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.1&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7k1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7k1w OCA], [https://pdbe.org/7k1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7k1w RCSB], [https://www.ebi.ac.uk/pdbsum/7k1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7k1w ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FIG4_HUMAN FIG4_HUMAN] Amyotrophic lateral sclerosis;Bilateral parasagittal parieto-occipital polymicrogyria;Charcot-Marie-Tooth disease type 4J;Yunis-Varon syndrome. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/FIG4_HUMAN FIG4_HUMAN] Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:17556371, PubMed:33098764). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate (PubMed:33098764). Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production (PubMed:33098764). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro (PubMed:17556371).<ref>PMID:17556371</ref> <ref>PMID:33098764</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Lees JA]]
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[[Category: Li P]]
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[[Category: Reinisch KM]]

Current revision

PIKfyve/Fig4/Vac14 complex centered on Fig4 - map3

PDB ID 7k1w

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