6k8j

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==Structure of NLRC4 CARD filament==
==Structure of NLRC4 CARD filament==
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<StructureSection load='6k8j' size='340' side='right'caption='[[6k8j]]' scene=''>
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<StructureSection load='6k8j' size='340' side='right'caption='[[6k8j]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K8J OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6K8J FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6k8j]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6K8J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6K8J FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6k8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k8j OCA], [http://pdbe.org/6k8j PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6k8j RCSB], [http://www.ebi.ac.uk/pdbsum/6k8j PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6k8j ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6k8j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6k8j OCA], [https://pdbe.org/6k8j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6k8j RCSB], [https://www.ebi.ac.uk/pdbsum/6k8j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6k8j ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry.
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== Function ==
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[https://www.uniprot.org/uniprot/NLRC4_HUMAN NLRC4_HUMAN] Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria (By similarity).[UniProtKB:Q3UP24]<ref>PMID:15107016</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bin W]]
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[[Category: Boo ZZ]]
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[[Category: Chenrui X]]
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[[Category: Gong Q]]
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[[Category: Jiawen Z]]
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[[Category: Wu B]]
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[[Category: Qin G]]
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[[Category: Xu C]]
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[[Category: Zhaozhi B]]
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[[Category: Zhang J]]

Current revision

Structure of NLRC4 CARD filament

PDB ID 6k8j

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