2bzs

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Current revision (13:59, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2bzs' size='340' side='right'caption='[[2bzs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2bzs' size='340' side='right'caption='[[2bzs]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2bzs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZS OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=2BZS FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2bzs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BZS FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1qr2|1qr2]], [[1sg0|1sg0]], [[1zx1|1zx1]], [[2qr2|2qr2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CB1:5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE'>CB1</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=2bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzs OCA], [http://pdbe.org/2bzs PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2bzs RCSB], [http://www.ebi.ac.uk/pdbsum/2bzs PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2bzs ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bzs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bzs OCA], [https://pdbe.org/2bzs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bzs RCSB], [https://www.ebi.ac.uk/pdbsum/2bzs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bzs ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Quinone reductase|Quinone reductase]]
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*[[Quinone reductase 3D structures|Quinone reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Doughty, S W]]
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[[Category: Abu Khader MM]]
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[[Category: Heap, J T]]
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[[Category: De Matteis C]]
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[[Category: Kellam, B]]
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[[Category: Doughty SW]]
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[[Category: Khader, M M.Abu]]
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[[Category: Heap JT]]
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[[Category: Matteis, C De]]
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[[Category: Kellam B]]
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[[Category: Minton, N]]
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[[Category: Minton N]]
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[[Category: Paoli, M]]
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[[Category: Paoli M]]
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[[Category: Cb1954]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Metal-binding]]
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[[Category: Nqo2]]
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[[Category: Oxidoreductase]]
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[[Category: Polymorphism]]
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[[Category: Zinc]]
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Current revision

Binding of anti-cancer prodrug CB1954 to the activating enzyme NQO2 revealed by the crystal structure of their complex.

PDB ID 2bzs

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OCA

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